Recommended Conferences

Clinical Pharmacy and Pharmacology

Paris, France
 

Atherosclerotic coronary lesions with inadequate compensatory enlargement have smaller plaque and vessel volumes: observations with three dimensional intravascular ultrasound in vivo

Author(s): von Birgelen C, Mintz GS, de Vrey EA, Kimura T, Popma JJ, et al.

Abstract

Objective: To compare vessel, lumen, and plaque volumes in atherosclerotic coronary lesions with inadequate compensatory enlargement versus lesions with adequate compensatory enlargement.

Design: 35 angiographically significant coronary lesions were examined by intravascular ultrasound (IVUS) during motorised transducer pullback. Segments 20 mm in length were analysed using a validated automated three dimensional analysis system. IVUS was used to classify lesions as having inadequate (group I) or adequate (group II) compensatory enlargement.

Results: There was no significant difference in quantitative angiographic measurements and the IVUS minimum lumen cross sectional area between groups I (n = 15) and II (n = 20). In group I, the vessel cross sectional area was 13.3 (3.0) mm2 at the lesion site and 14.4 (3.6) mm2 at the distal reference (p < 0.01), whereas in group II it was 17.5 (5.6) mm2 at the lesion site and 14.0 (6.0) mm2 at the distal reference (p < 0.001). Vessel and plaque cross sectional areas were significantly smaller in group I than in group II (13.3 (3.0) v 17.5 (5.6) mm2, p < 0.01; and 10.9 (2.8) v 15.2 (4.9) mm2; p < 0.005). Similarly, vessel and plaque volume were smaller in group I (291.0 (61.0) v 353.7 (110.0) mm3, and 177.5 (48.4) v 228.0 (92.8) mm3, p < 0.05 for both). Lumen areas and volumes were similar.

Conclusions: In lesions with inadequate compensatory enlargement, both vessel and plaque volume appear to be smaller than in lesions with adequate compensatory enlargement.

Similar Articles

Physiological basis of clinically used coronary hemodynamic indices

Author(s): Spaan JA, Piek JJ, Hoffman JI, Siebes M

Pressure-flow relations in coronary circulation

Author(s): Hoffman JI, Spaan JA

Pathophysiology of coronary artery disease

Author(s): Libby P, Theroux P

Multicentric inflammation in epicardial coronary arteries of patients dying of acute myocardial infarction

Author(s): Spagnoli LG, Bonanno E, Mauriello A, Palmieri G, Partenzi A, et al.

Chest pain relief by nitroglycerin does not predict active coronary artery disease

Author(s): Henrikson CA, Howell EE, Bush DE, Miles JS, Meininger GR, et al.

Exercise-induced ST depression in the diagnosis of coronary artery disease

Author(s): Gianrossi R, Detrano R, Mulvihill D, Lehmann K, Dubach P, et al.

Effect of myocardial ischemia on cardiac troponin I and T

Author(s): Carlson RJ, Navone A, McConnell JP, Burritt M, Castle MC, et al.

Prevalence and determinants of troponin T elevation in the general population

Author(s): Wallace TW, Abdullah SM, Drazner MH, Das SR, Khera A, et al.

Utility of myocardial perfusion imaging in patients with low-risk treadmill scores

Author(s): Poornima IG, Miller TD, Christian TF, Hodge DO, Bailey KR, et al.

Magnetic resonance spectroscopy in myocardial disease

Author(s): Hudsmith LE, Neubauer S

Accuracy of MSCT coronary angiography with 64-slice technology: first experience

Author(s): Leschka S, Alkadhi H, Plass A, Desbiolles L, Grünenfelder J, et al.

Characteristics of coronary plaques before angiographic progression determined by Multi-Slice CT

Author(s): Leber AW, von Ziegler F, Becker A, Becker CR, Reiser M, et al.

Influence of heart rate on the diagnostic accuracy of dual-source computed tomography coronary angiography

Author(s): Ropers U, Ropers D, Pflederer T, Anders K, Kuettner A, et al.

Radiation dose in computed tomography of the heart

Author(s): Morin RL, Gerber TC, McCollough CH

Radiation exposure during cardiac CT: effective doses at multi-detector row CT and electron-beam CT

Author(s): Hunold P, Vogt FM, Schmermund A, Debatin JF, Kerkhoff G, et al.

Prognostic value of dobutamine stress myocardial contrast perfusion echocardiography

Author(s): Tsutsui JM, Elhendy A, Anderson JR, Xie F, McGrain AC, et al.

N Engl J Med 331: 489-495

Author(s): Serruys PW, de Jaegere P, Kiemeneij F, Macaya C, Rutsch W, et al.

Major clinical events after coronary stenting

Author(s): Sutton JM, Ellis SG, Roubin GS, Pinkerton CA, King SB 3rd, et al.

Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease

Author(s): Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, et al.

Coronary revascularization in context

Author(s): Lange RA, Hillis LD

Coronary artery disease in Saudi Arabia

Author(s): Al-Nozha MM, Arafah MR, Al-Mazrou YY, Al-Maatouq MA, Khan NB, et al.

Diabetes mellitus in Saudi Arabia

Author(s): Al-Nozha MM, Al-Maatouq MA, Al-Mazrou YY, Al-Harthi SS, Arafah MR, et al.

Obesity in Saudi Arabia

Author(s): Al-Nozha MM, Al-Mazrou YY, Al-Maatouq MA, Arafah MR, Khalil MZ, et al.

Metabolic syndrome in Saudi Arabia

Author(s): Al-Nozha M, Al-Khadra A, Arafah MR, Al-Maatouq MA, Khalil MZ, et al.

Hypertension in Saudi Arabia

Author(s): Al-Nozha MM, Abdullah M, Arafah MR, Khalil MZ, Khan NB, et al.

Hyperlipidemia in Saudi Arabia

Author(s): Al-Nozha MM, Arafah MR, Al-Maatouq MA, Khalil MZ, Khan NB, et al.

Interaction between fatness and fitness on CVD risk factors in Asian youth

Author(s): Jekal Y, Kim ES, Im JA, Park JH, Lee MK, et al.

Body fatness and clustering of cardiovascular disease risk factors in Portuguese children and adolescents

Author(s): Ribeiro JC, Guerra S, Oliveira J, Andersen LB, Duarte JA, et al.

Changes in secondary prevention of coronary artery disease in the post-discharge period over the decade 1997-2007

Author(s): Pajak A, Jankowski P, Kawecka-Jaszcz K, Surowiec S, Wolfshaut R, et al.

Secondary prevention through cardiac rehabilitation: from knowledge to implementation

Author(s): Piepoli MF, Corrá U, Benzer W, Bjarnason-Wehrens B, Dendale P, et al.

Secondary prevention of coronary artery disease in hospital practice over the decade 1996-2006

Author(s): Jankowski P, Kawecka-Jaszcz K, Pajak A, Surowiec S, Wolfshaut R, et al.