Recommended Conferences

Clinical Pharmacy and Pharmacology

Paris, France
 

Prevalence and determinants of troponin T elevation in the general population

Author(s): Wallace TW, Abdullah SM, Drazner MH, Das SR, Khera A, et al.

Abstract

Background: The prevalence and determinants of cardiac troponin T (cTnT) elevation in the general population are unknown, and the significance of minimally increased cTnT remains controversial. Our objective was to determine the prevalence and determinants of cTnT elevation in a large, representative sample of the general population.

Methods and results: cTnT was measured from stored plasma samples in 3557 subjects of the Dallas Heart Study, a population-based sample. cTnT elevation (> or =0.01 microg/L) was correlated with clinical variables and cardiac MRI findings. The sample weight-adjusted prevalence of cTnT elevation in the general population was 0.7%. In univariable analyses, cTnT elevation was associated with older age, black race, male sex, coronary artery calcium by electron beam CT, a composite marker of congestive heart failure (CHF), left ventricular hypertrophy (LVH), diabetes mellitus (DM), and chronic kidney disease (CKD) (P<0.001 for each). Subjects with minimally increased (0.01 to 0.029 microg/L) and increased (> or =0.03 microg/L) cTnT had a similar prevalence of these characteristics. In multivariable logistic regression analysis, LVH, CHF, DM, and CKD were independently associated with cTnT elevation.

Conclusions: In the general population, cTnT elevation is rare in subjects without CHF, LVH, CKD, or DM, suggesting that the upper limit of normal for the immunoassay should be <0.01 microg/L. Even minimally increased cTnT may represent subclinical cardiac injury and have important clinical implications, a hypothesis that should be tested in longitudinal outcome studies.

Similar Articles

Physiological basis of clinically used coronary hemodynamic indices

Author(s): Spaan JA, Piek JJ, Hoffman JI, Siebes M

Pressure-flow relations in coronary circulation

Author(s): Hoffman JI, Spaan JA

Pathophysiology of coronary artery disease

Author(s): Libby P, Theroux P

Multicentric inflammation in epicardial coronary arteries of patients dying of acute myocardial infarction

Author(s): Spagnoli LG, Bonanno E, Mauriello A, Palmieri G, Partenzi A, et al.

Chest pain relief by nitroglycerin does not predict active coronary artery disease

Author(s): Henrikson CA, Howell EE, Bush DE, Miles JS, Meininger GR, et al.

Exercise-induced ST depression in the diagnosis of coronary artery disease

Author(s): Gianrossi R, Detrano R, Mulvihill D, Lehmann K, Dubach P, et al.

Effect of myocardial ischemia on cardiac troponin I and T

Author(s): Carlson RJ, Navone A, McConnell JP, Burritt M, Castle MC, et al.

Utility of myocardial perfusion imaging in patients with low-risk treadmill scores

Author(s): Poornima IG, Miller TD, Christian TF, Hodge DO, Bailey KR, et al.

Magnetic resonance spectroscopy in myocardial disease

Author(s): Hudsmith LE, Neubauer S

Accuracy of MSCT coronary angiography with 64-slice technology: first experience

Author(s): Leschka S, Alkadhi H, Plass A, Desbiolles L, Grünenfelder J, et al.

Characteristics of coronary plaques before angiographic progression determined by Multi-Slice CT

Author(s): Leber AW, von Ziegler F, Becker A, Becker CR, Reiser M, et al.

Influence of heart rate on the diagnostic accuracy of dual-source computed tomography coronary angiography

Author(s): Ropers U, Ropers D, Pflederer T, Anders K, Kuettner A, et al.

Radiation dose in computed tomography of the heart

Author(s): Morin RL, Gerber TC, McCollough CH

Radiation exposure during cardiac CT: effective doses at multi-detector row CT and electron-beam CT

Author(s): Hunold P, Vogt FM, Schmermund A, Debatin JF, Kerkhoff G, et al.

Prognostic value of dobutamine stress myocardial contrast perfusion echocardiography

Author(s): Tsutsui JM, Elhendy A, Anderson JR, Xie F, McGrain AC, et al.

N Engl J Med 331: 489-495

Author(s): Serruys PW, de Jaegere P, Kiemeneij F, Macaya C, Rutsch W, et al.

Major clinical events after coronary stenting

Author(s): Sutton JM, Ellis SG, Roubin GS, Pinkerton CA, King SB 3rd, et al.

Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease

Author(s): Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, et al.

Coronary revascularization in context

Author(s): Lange RA, Hillis LD

Coronary artery disease in Saudi Arabia

Author(s): Al-Nozha MM, Arafah MR, Al-Mazrou YY, Al-Maatouq MA, Khan NB, et al.

Diabetes mellitus in Saudi Arabia

Author(s): Al-Nozha MM, Al-Maatouq MA, Al-Mazrou YY, Al-Harthi SS, Arafah MR, et al.

Obesity in Saudi Arabia

Author(s): Al-Nozha MM, Al-Mazrou YY, Al-Maatouq MA, Arafah MR, Khalil MZ, et al.

Metabolic syndrome in Saudi Arabia

Author(s): Al-Nozha M, Al-Khadra A, Arafah MR, Al-Maatouq MA, Khalil MZ, et al.

Hypertension in Saudi Arabia

Author(s): Al-Nozha MM, Abdullah M, Arafah MR, Khalil MZ, Khan NB, et al.

Hyperlipidemia in Saudi Arabia

Author(s): Al-Nozha MM, Arafah MR, Al-Maatouq MA, Khalil MZ, Khan NB, et al.

Interaction between fatness and fitness on CVD risk factors in Asian youth

Author(s): Jekal Y, Kim ES, Im JA, Park JH, Lee MK, et al.

Body fatness and clustering of cardiovascular disease risk factors in Portuguese children and adolescents

Author(s): Ribeiro JC, Guerra S, Oliveira J, Andersen LB, Duarte JA, et al.

Changes in secondary prevention of coronary artery disease in the post-discharge period over the decade 1997-2007

Author(s): Pajak A, Jankowski P, Kawecka-Jaszcz K, Surowiec S, Wolfshaut R, et al.

Secondary prevention through cardiac rehabilitation: from knowledge to implementation

Author(s): Piepoli MF, Corrá U, Benzer W, Bjarnason-Wehrens B, Dendale P, et al.

Secondary prevention of coronary artery disease in hospital practice over the decade 1996-2006

Author(s): Jankowski P, Kawecka-Jaszcz K, Pajak A, Surowiec S, Wolfshaut R, et al.