Author(s): Bouchillon SK, Badal RE, Hoban DJ, Hawser SP
The Study for Monitoring Antimicrobial Resistance Trends is an ongoing global surveillance program that has monitored the susceptibilities of Gram-negative bacilli from inpatient urinary tract infections (UTIs) since late 2009.Objective
This analysis reports on the in vitro susceptibility of 2,135 isolates collected by 24 US sites from hospitalized patients with UTIs between 2009 and 2011.Methods
Minimum inhibitory concentrations and susceptibility were determined according to the guidelines of the Clinical and Laboratory Standards Institute.Results
Of the isolates collected, 88.6% (1,892) were Enterobacteriaceae, which included 48.9% (n = 1,045) Escherichia coli, 14.5% (n = 310) Klebsiella pneumoniae, 6.4% (n = 136) Proteus mirabilis, 2.5% (n = 54) Klebsiella oxytoca, and 16.3% (n = 347) other Enterobacteriaceae species. Overall, 6.8% of E coli, 10.3% of K pneumoniae, 3.7% of P mirabilis, and 11.1% of K oxytoca isolates were extended-spectrum β-lactamase−producing strains. Of the Enterobacteriaceae isolates, 67.5% were community associated and 26.9% were hospital associated (5.7% had no demographics). Highest overall rates of activity for the study period were seen with amikacin, ertapenem, and imipenem. The least active antimicrobials tested were ampicillin-sulbactam, ciprofloxacin, and levofloxacin.Conclusions
Ertapenem, imipenem, and amikacin were the most active study drugs against extended-spectrum β-lactamase−producing strains, although the activity against extended-spectrum β-lactamase−producing K pneumoniae did not exceed 69% throughout the study period. The results of the Study for Monitoring Antimicrobial Resistance Trends surveillance study document the rates of antimicrobial resistance in UTI pathogens in the United States, which can assist health care practitioners in selecting the appropriate treatment for UTIs.
Referred From: https://doi.org/10.1016/j.clinthera.2013.03.022
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Author(s): Greenhow TL, Hung YY, Herz AM, Losada E, Pantell RH
Author(s): Zorc JJ, Kiddoo DA, Shaw KN
Author(s): Habib S
Author(s): Freedman AL
Author(s): Sheikh N, Morone NE, Bost JE, Farerell MH
Author(s): Shaikh N, Morone NE, Lopez J, Chianese J, Sangvai S, et al.
Author(s): Korbel L, Howell M, Spencer JD
Author(s): White B
Author(s): Nwafia IN, Ohanu ME, Ebede SO, Ozumba UC
Author(s): Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM
Author(s): Zohreh N, Alireza
Author(s): Akortha EE, Ibadin OK
Author(s): Singh SD, Madhup SK
Author(s): Matthew F. Daley, Sharisse M, Arnold R, Karen A, Glenn Liza M, et al.
Author(s): den Heijer CD, Penders J, Donker GA, Bruggeman CA Bruggeman CA, et al.
Author(s): Muoneke VU, Ibekwe MU, Ibekwe RC
Author(s): Kline KA, Lewis AL
Author(s): Gunduz, Suzan, HaticeUludaÄ?Altun
Author(s): Msaki BP, Mshana SE, Hokororo A, Hokororo A, Mazigo HD, et al.
Author(s): Edlin RS, Shapiro DJ, Hersh AL, Copper HL
Author(s): Nieminen O, Korppi M, Helminen M
Author(s): Sanchez GV, Baird AM, Karlowsky JA, Master RN, Bordon JM
Author(s): Bryce A, Hay AD, Lane IF, Thornton HV, Wootton M, et al.
Author(s): Elder JS
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