Acute effects of aerobic exercise on negative affect and obsessions and compulsions in individuals with obsessive-compulsive disorder

Author(s): Abrantes AM, Farris SG, Brown RA, Greenberg BD, Strong DR, et al.



The acute effects of aerobic exercise on improved mood and anxiety reduction have been demonstrated across clinical and nonclinical populations. Limited work has evaluated the acute effects of aerobic exercise on negative affect, obsessions, and compulsions in patients with Obsessive Compulsive Disorder (OCD).


Fifty-five patients (64% female) with treatment-resistant OCD were randomized to either 12 weeks of aerobic exercise (AE) or health education contact (HEC) control. Participants rated negative affect (i.e., mood and anxiety), obsessions and compulsions before and after each weekly AE or HEC session. Multilevel models were constructed to evaluate the effect of intervention condition, treatment week (time), and their interaction in terms of acute change in affect, obsession, and compulsions.


Results reflected a main effect of condition, such that AE resulted in significantly larger increases in positive mood, and reductions in anxiety and compulsions, as compared to HEC. There was also a main effect of time in predicting acute anxiety reduction, such that linear reductions in anxiety over the course of treatment were observed. No significant effects were observed for acute changes in obsessions.


The sample was small and was limited in demographic heterogeneity. Bouts of aerobic exercise were not standardized in terms of duration and mode, which could impact affective response to exercise, and acute affective OCD effects were exclusively self-reported.


The current findings may help elucidate potential mechanisms of action of exercise on OCD outcomes. In addition, these results point toward the potential of designing exercise interventions that can teach patients to utilize individual bouts of physical activity, “in-the-moment” to improve mood and reduce anxiety and compulsions.

Similar Articles

Virtual Reality-Based Exercise with Exergames as Medicine in Different Contexts: A Short Review

Author(s): Costa MTS, Vieira LP, Barbosa EO, Mendes Oliveira L, Maillot P, et al.

Acute Effects of Aerobic Exercise on Executive Function and Attention in Adult Patients With ADHD

Author(s): Mehren A, Özyurt J, Lam AP, Brandes M, Müller HHO, et al.

High-Intensity Aerobic Exercise Acutely Increases Brain-derived Neurotrophic Factor

Author(s): Ross RE, Saladin ME, George MS, Gregory CM

Differential cognitive effects of energy drink ingredients: Caffeine, taurine, and glucose

Author(s): Giles GE, Mahoney CR, Brunyé TT, Gardony AL, Taylor HA, et al.

Cognitive influence of a 5-h ENERGY® shot: Are effects perceived or real?

Author(s): Buckenmeyer PJ, Bauer JA, Hokanson JF, Hendrick JL