Author(s): Schmitt K, Holsboer-Trachler E, EC-Kert A
The protein brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors involved in plasticity of neurons in several brain regions. There are numerous evidence that BDNF expression is decreased by experiencing psychological stress and that, accordingly, a lack of neurotrophic support causes major depression. Furthermore, disruption in sleep homeostatic processes results in higher stress vulnerability and is often associated with stress-related mental disorders. Recently, we reported, for the first time, a relationship between BDNF and insomnia and sleep deprivation (SD). Using a biphasic stress model as explanation approach, we discuss here the hypothesis that chronic stress might induce a deregulation of the hypothalamic-pituitary-adrenal system. In the long-term it leads to sleep disturbance and depression as well as decreased BDNF levels, whereas acute stress like SD can be used as therapeutic intervention in some insomniac or depressed patients as compensatory process to normalize BDNF levels. Indeed, partial SD (PSD) induced a fast increase in BDNF serum levels within hours after PSD which is similar to effects seen after ketamine infusion, another fast-acting antidepressant intervention, while traditional antidepressants are characterized by a major delay until treatment response as well as delayed BDNF level increase.
Author(s): Allen NHP, Burns A
Author(s): Holmes C
Author(s): Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Engchild J, et al.
Author(s): De Maio A
Author(s): Wu C
Author(s): Walter S, Buchner J
Author(s): Borges JC, Ramos CH
Author(s): Lu RC, Tan MS, Wang H, Xie AM, Yu JT, et al.
Author(s): Bekinstein P, Cammarota M, Katche C, Slipczuk L, Rossato JI, et al.
Author(s): Honea RA, Cruchaga C, Perea RD, Saykin AJ, Burns JM, et al.
Author(s): Hu Y, Russek S
Author(s): Philips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, et al.
Author(s): Ciaramella A, Salani F, Bizzoni F, Orfei MD, Langella Rangelucci F, et al.
Author(s): Fahnestock M, Garzon D, Holsinger RM, Michalski B
Author(s): Ferreer I, Marin C, Rey MJ, Ribalta T, Goutane, et al.
Author(s): Voineskos AN, Lerch JP, Felsky D, Shaikh S, Rajji TK, et al.
Author(s): Cook EH, Fletcher KE, Wainwright M, Marks N, Yan SY, et al.
Author(s): Martin P, Waters N, Schmidt CJ, Carlsson A, Carlsson ML
Author(s): Choi MJ, Lee HJ, Ham BJ, Cha JH, Ryu SH, et al.
Author(s): Lancot KL, Herrmann N, Mazzotta P
Author(s): Nacmias B, Tedde A, Forleo P, Piacentini S, Guamieri BM, et al.
Author(s): Fan JB, Sklar P
Author(s): Anguelova M, Benkelfat C, Turecki G
Author(s): Deng Y, Sun Y, Shi JJ, Zhang SZ
Author(s): Huang EJ, Reichardt LF