Author(s): Barros L, Eichwald T, Solano AF, Scheffer D, da Silva RA, et al.
Obesity and metabolic disorders are increasing worldwide and are associated with brain atrophy and dysfunction, which are risk factors for late-onset dementia and Alzheimer's disease. Epidemiological studies demonstrated that changes in lifestyle, including the frequent practice of physical exercise are able to prevent and treat not only obesity/metabolic disorders, but also to improve cognitive function and dementia. Several biochemical pathways and epigenetic mechanisms have been proposed to understand the beneficial effects of physical exercise on cognition. This manuscript revised central ongoing research on epigenetic mechanisms induced by exercise and the beneficial effects on obesity-associated cognitive decline, highlighting potential mechanistic mediators.
Author(s): Caillouet KA, Cosio-Lima L
Author(s): Costa MTS, Vieira LP, Barbosa EO, Mendes Oliveira L, Maillot P, et al.
Author(s): Shigdel R, Stubbs B, Sui X, Ernstsen L
Author(s): Abrantes AM, Farris SG, Brown RA, Greenberg BD, Strong DR, et al.
Author(s): Garcia D, Archer T, Moradi S, Andersson-Arntén A
Author(s): Archer T, Lindahl M
Author(s): Smith L, Jackson SE, Pardhan S, López-Sánchez GF, Hu L, et al.
Author(s): Mehren A, Özyurt J, Lam AP, Brandes M, Müller HHO, et al.
Author(s): Wassenaar TM, Wheatley CM, Beale N, Salvan P, Meaney A, et al.
Author(s): Garcia D, Daniele T, Archer T
Author(s): Loprinzi PD
Author(s): Fortune JM, Kelly ÁM, Robertson IH, Hussey J
Author(s): Pedersen BK
Author(s): Ross RE, Saladin ME, George MS, Gregory CM
Author(s): Stavestrand SH, Sirevåg K, Nordhus IH, Sjøbø T, Endal TB, et al.
Author(s): Amjad I, Toor H, Niazi IK, Afzal H, Jochumsen M, et al.
Author(s): Giles GE, Mahoney CR, Brunyé TT, Gardony AL, Taylor HA, et al.
Author(s): Benson S, Tiplady B, Scholey A
Author(s): Wesnes KA, Brooker H, Watson AW, Bal W, Okello E
Author(s): Buckenmeyer PJ, Bauer JA, Hokanson JF, Hendrick JL
Author(s): Garcia D, Archer T
Author(s): Malik AA, Williams CA, Weston KL, Barker AR