Author(s): Voineskos AN, Lerch JP, Felsky D, Shaikh S, Rajji TK, et al.
Context The brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) polymorphism may predict the risk of Alzheimer disease (AD). However, genetic association studies of the BDNF gene with AD have produced equivocal results. Imaging-genetics strategies may clarify the manner in which BDNF gene variation predicts the risk of AD via characterization of its effects on at-risk structures or neural networks susceptible in this disorder.
Objective To determine whether the BDNF Val66Met gene variant interacts with age to predict brain and cognitive measures in healthy volunteers across the adult lifespan in an intermediate phenotype pattern related to AD by examining (1) cortical thickness, (2) fractional anisotropy of white matter tracts (ie, white matter integrity), and (3) episodic memory performance.
Design A cross-sectional study using genetics, high-resolution magnetic resonance imaging, diffusion tensor imaging, and cognitive testing in healthy individuals spanning the adult lifespan.
Author(s): Allen NHP, Burns A
Author(s): Holmes C
Author(s): Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Engchild J, et al.
Author(s): De Maio A
Author(s): Wu C
Author(s): Walter S, Buchner J
Author(s): Borges JC, Ramos CH
Author(s): Lu RC, Tan MS, Wang H, Xie AM, Yu JT, et al.
Author(s): Bekinstein P, Cammarota M, Katche C, Slipczuk L, Rossato JI, et al.
Author(s): Schmitt K, Holsboer-Trachler E, EC-Kert A
Author(s): Honea RA, Cruchaga C, Perea RD, Saykin AJ, Burns JM, et al.
Author(s): Hu Y, Russek S
Author(s): Philips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, et al.
Author(s): Ciaramella A, Salani F, Bizzoni F, Orfei MD, Langella Rangelucci F, et al.
Author(s): Fahnestock M, Garzon D, Holsinger RM, Michalski B
Author(s): Ferreer I, Marin C, Rey MJ, Ribalta T, Goutane, et al.
Author(s): Cook EH, Fletcher KE, Wainwright M, Marks N, Yan SY, et al.
Author(s): Martin P, Waters N, Schmidt CJ, Carlsson A, Carlsson ML
Author(s): Choi MJ, Lee HJ, Ham BJ, Cha JH, Ryu SH, et al.
Author(s): Lancot KL, Herrmann N, Mazzotta P
Author(s): Nacmias B, Tedde A, Forleo P, Piacentini S, Guamieri BM, et al.
Author(s): Fan JB, Sklar P
Author(s): Anguelova M, Benkelfat C, Turecki G
Author(s): Deng Y, Sun Y, Shi JJ, Zhang SZ
Author(s): Huang EJ, Reichardt LF
