Author(s): Ivanovski S, Haase HR, Bartold PM
The successful regeneration of periodontal tissues is dependent, in part, on the ability of cells to reconstitute the mineralized tissues of cementum and bone. The aim of the present study was to characterize regeneration-associated cells in terms of their ability to express mineralized tissue macromolecules. Following guided tissue regeneration, cell cultures were established from regenerating tissue, periodontal ligament, and gingiva. Additionally, these cells were transfected, and single-cell-derived clones were established. Following treatment with platelet-derived growth factor-BB and insulin-derived growth factor-1, the presence of mRNA for alkaline phosphatase, osteocalcin, bone sialoprotein, osteopontin, and bone morphogenetic proteins-2 and -4 was assessed. The three cell types expressed similar mRNA levels for alkaline phosphatase, bone morphogenetic protein-2, and bone morphogenetic protein-4, whereas the expression of osteopontin, osteocalcin, and bone sialoprotein was greater in the periodontal ligament and regenerating tissue fibroblasts compared with the gingival fibroblasts. The two growth factors did not affect the expression of any of the genes. This study has identified markers that correlate with the known ability of periodontal ligament and regenerating tissue-derived fibroblasts to facilitate regeneration of the mineralized tissues of the periodontium.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/11597029
Author(s): Rimondini L, Mele S
Author(s): Silvério KG, Benatti BB, Casati MZ, Sallum EA, Nociti FH Jr
Author(s): Morsczeck C, Schmalz G, Reichert TE, Völlner F, Galler K, et al.
Author(s): McCulloch CA, Nemeth E, Lowenberg B, Melcher AH
Author(s): Sodek J
Author(s): Somerman MJ, Archer SY, Imm GR, Foster RA
Author(s): Giannopoulou C, Cimasoni G
Author(s): Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, et al.
Author(s): Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, et al.
Author(s): Shi S, Bartold PM, Miura M, Seo BM, Robey PG, et al.
Author(s): Tomokiyo A, Maeda H, Fujii S, Wada N, Shima K, et al.
Author(s): Feng F, Akiyama K, Liu Y, Yamaza T, Wang TM, et al.
Author(s): Iwata T, Yamato M, Zhang Z, Mukobata S, Washio K, et al.
Author(s): Park JC, Kim JM, Jung IH, Kim JC, Choi SH, et al.
Author(s): Choi JK, Hwang HI, Jang YJ
Author(s): Bright R, Hynes K, Gronthos S, Bartold PM
Author(s): Tan J, Xu X, Lin J, Fan L, Zheng Y, et al.
Author(s): Bojic S, Volarevic V, Ljujic B, Stojkovic M
Author(s): Hynes K, Menicanin D, Gronthos S, Bartold PM
Author(s): Liu J, Yu F, Sun Y, Jiang B, Zhang W, et al.
Author(s): Ding G, Niu J, Wei F
Author(s): Nakajima R, Ono M, Hara ES, Oida Y, Shinkawa S, et al.
Author(s): Hakki SS, Kayis SA, Hakki EE, Bozkurt SB, Duruksu G, et al.
Author(s): Lei M, Li K, Li B, Gao LN, Chen FM, et al.
Author(s): Gronthos S, Mrozik K, Shi S, Bartold PM
Author(s): Techawattanawisal W, Nakahama K, Komaki M, Abe M, Takagi Y, et al.
Author(s): Huang CY, Pelaez D, Dominguez-Bendala J, Garcia-Godoy F, Cheung HS
Author(s): Gay IC, Chen S, MacDougall M
Author(s): Li B, Jung HJ, Kim SM, Kim MJ, Jahng JW, et al.
Author(s): Kim SH, Kim KH, Seo BM, Koo KT, Kim TI, et al.
Author(s): Yamada S, Ozawa Y, Tomoeda M, Matoba R, Matsubara K, et al.
Author(s): Van Dijk LJ, Schakenraad JM, van der Voort HM, Herkströter FM, Busscher HJ
Author(s): Lang H, Schüler N, Nolden R
Author(s): Malekzadeh R, Hollinger JO, Buck D, Adams DF, McAllister BS
Author(s): Zhao M, Jin Q, Berry JE, Nociti FH Jr, Giannobile WV, et al.
Author(s): Kim JH, Park CH, Perez RA, Lee HY, Jang JH, et al.
Author(s): Ivanovski S, Vaquette C, Gronthos S, Hutmacher DW, Bartold PM
Author(s): Choi HD, Noh WC, Park JW, Lee JM, Suh JY
Author(s): Fujita T, Otsuka-Tanaka Y, Tahara H, Ide T, Abiko Y, et al.
Author(s): Elçin YM, Inanç B, Elçin AE
Author(s): Gronthos S, Zannettino AC, Hay SJ, Shi S, Graves SE, et al.
Author(s): Xu Q, Li B, Yuan L, Dong Z, Zhang H, et al.