Author(s): Ivanovski S, Vaquette C, Gronthos S, Hutmacher DW, Bartold PM
For a successful clinical outcome, periodontal regeneration requires the coordinated response of multiple soft and hard tissues (periodontal ligament, gingiva, cementum, and bone) during the wound-healing process. Tissue-engineered constructs for regeneration of the periodontium must be of a complex 3-dimensional shape and adequate size and demonstrate biomechanical stability over time. A critical requirement is the ability to promote the formation of functional periodontal attachment between regenerated alveolar bone, and newly formed cementum on the root surface. This review outlines the current advances in multiphasic scaffold fabrication and how these scaffolds can be combined with cell- and growth factor-based approaches to form tissue-engineered constructs capable of recapitulating the complex temporal and spatial wound-healing events that will lead to predictable periodontal regeneration. This can be achieved through a variety of approaches, with promising strategies characterized by the use of scaffolds that can deliver and stabilize cells capable of cementogenesis onto the root surface, provide biomechanical cues that encourage perpendicular alignment of periodontal fibers to the root surface, and provide osteogenic cues and appropriate space to facilitate bone regeneration. Progress on the development of multiphasic constructs for periodontal tissue engineering is in the early stages of development, and these constructs need to be tested in large animal models and, ultimately, human clinical trials.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/25139362
Author(s): Rimondini L, Mele S
Author(s): Silvério KG, Benatti BB, Casati MZ, Sallum EA, Nociti FH Jr
Author(s): Morsczeck C, Schmalz G, Reichert TE, Völlner F, Galler K, et al.
Author(s): McCulloch CA, Nemeth E, Lowenberg B, Melcher AH
Author(s): Sodek J
Author(s): Somerman MJ, Archer SY, Imm GR, Foster RA
Author(s): Giannopoulou C, Cimasoni G
Author(s): Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, et al.
Author(s): Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, et al.
Author(s): Shi S, Bartold PM, Miura M, Seo BM, Robey PG, et al.
Author(s): Tomokiyo A, Maeda H, Fujii S, Wada N, Shima K, et al.
Author(s): Feng F, Akiyama K, Liu Y, Yamaza T, Wang TM, et al.
Author(s): Iwata T, Yamato M, Zhang Z, Mukobata S, Washio K, et al.
Author(s): Park JC, Kim JM, Jung IH, Kim JC, Choi SH, et al.
Author(s): Choi JK, Hwang HI, Jang YJ
Author(s): Bright R, Hynes K, Gronthos S, Bartold PM
Author(s): Tan J, Xu X, Lin J, Fan L, Zheng Y, et al.
Author(s): Bojic S, Volarevic V, Ljujic B, Stojkovic M
Author(s): Hynes K, Menicanin D, Gronthos S, Bartold PM
Author(s): Liu J, Yu F, Sun Y, Jiang B, Zhang W, et al.
Author(s): Ding G, Niu J, Wei F
Author(s): Nakajima R, Ono M, Hara ES, Oida Y, Shinkawa S, et al.
Author(s): Hakki SS, Kayis SA, Hakki EE, Bozkurt SB, Duruksu G, et al.
Author(s): Lei M, Li K, Li B, Gao LN, Chen FM, et al.
Author(s): Gronthos S, Mrozik K, Shi S, Bartold PM
Author(s): Techawattanawisal W, Nakahama K, Komaki M, Abe M, Takagi Y, et al.
Author(s): Huang CY, Pelaez D, Dominguez-Bendala J, Garcia-Godoy F, Cheung HS
Author(s): Gay IC, Chen S, MacDougall M
Author(s): Li B, Jung HJ, Kim SM, Kim MJ, Jahng JW, et al.
Author(s): Kim SH, Kim KH, Seo BM, Koo KT, Kim TI, et al.
Author(s): Yamada S, Ozawa Y, Tomoeda M, Matoba R, Matsubara K, et al.
Author(s): Van Dijk LJ, Schakenraad JM, van der Voort HM, Herkströter FM, Busscher HJ
Author(s): Lang H, Schüler N, Nolden R
Author(s): Malekzadeh R, Hollinger JO, Buck D, Adams DF, McAllister BS
Author(s): Zhao M, Jin Q, Berry JE, Nociti FH Jr, Giannobile WV, et al.
Author(s): Kim JH, Park CH, Perez RA, Lee HY, Jang JH, et al.
Author(s): Choi HD, Noh WC, Park JW, Lee JM, Suh JY
Author(s): Fujita T, Otsuka-Tanaka Y, Tahara H, Ide T, Abiko Y, et al.
Author(s): Elçin YM, Inanç B, Elçin AE
Author(s): Gronthos S, Zannettino AC, Hay SJ, Shi S, Graves SE, et al.
Author(s): Ivanovski S, Haase HR, Bartold PM
Author(s): Xu Q, Li B, Yuan L, Dong Z, Zhang H, et al.