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Adolescent Health Medicine

Dubai, UAE
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Peripheral T-cell lymphoma presenting as predominant liver disease: a report of three cases

Author(s): Gaulard P, Zafrani ES, Mavier P, Rocha FD, Farcet JP, et al.

Abstract

ThreecasesofapeculiarformofperipheralT-celllymphomapresentingaspredominanthepaticdiseasewithsplenomegalyarereported.Thethreepatientshadmarkedliverenlargementwithoutlymphadenopathy;whitebloodcellcountwasnormal,andmodificationsofhepatictestsweremild.Inthethreecases,thediagnosisofthelymphomawasmainlybasedontheresultsofhepaticmorphologicalchanges.Liverinvolvementwashistologicallycharacterizedbyapredominantlysinusoidalinfiltrationbytumorcellsinthethreecases,associatedwithperisinusoidalfibrosisintwoofthem;portalinfiltrationwasnotedintwopatients.ImmunopathologicalstudyshowedthattumorcellswereT-lymphoidcellsthatweredifferentfromnormalT-lymphocytesbythelackofexpressionofoneT-cellmembraneantigen,i.e.,Leu-1.Thesefindingssuggestthatadistinctclinical,pathologicalandimmunopathologicalentitymightbeindividualizedwithinthelargegroupofT-celllymphomas.

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