Recommended Conferences

Adolescent Health Medicine

Dubai, UAE
Related Subjects
 

Post transplant CD8+ gammadelta T-cell lymphoma associated with human herpes virus-6 infection

Author(s): Lin WC, Moore JO, Mann KP, Traweek ST, Smith C

Abstract

GammadeltaT-celllymphomaisarareT-celllymphoproliferativedisorderthathasbeenreportedinbothimmunocompetentandimmunocompromisedpersons.ThisreportdescribesafortyeightyearoldpatientwhodevelopedgammadeltaT-celllymphomafouryearsafterundergoingliving-relatedkidneytransplantation.ThelymphomaexpressedCD2,CD3,CD7,CD8andCD56,andthegammadeltaT-cellreceptoranddidnotexpressCD5,CD4andthealphabetaT-cellreceptor.Inaddition,HHV-6wasculturedfromthepatient'sbonemarrow,markingthefirsttimethatthisvirushasbeenassociatedwithgammadeltaT-celllymphoma.SinceallpatientswithgammadeltaT-celllymphomadescribedtodatehaverespondedpoorlytostandardcombinationchemotherapies,thepatientwastreatedwiththepurineanalogue2-chlorodeoxyadenosine.Whileherespondedtransientlytotreatment,longtermremissionwasnotachievedindicatingthatadditionaltherapeuticapprochesstillneedtobedeveloped,forthemanagementofthisdisorder.

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