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Oxford University Press, Oxford (1993) Google Scholar Centers for Disease Control and Prevention: Prevalence of arthritis—US 1997. MMWR 50, 334–336, [CD] (2001)Guillemin, F., Saraux, A., Guggenbuhl, P., et al.: Prevalence of rheumatoid arthritis in France: 2001. Ann. Rheum. Dis. 64, 1427–1430 (2005)Article Google Scholar Alamanos, Y., Voulgari, P.V., Drosos, A.A.: Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology Criteria: a systematic review. Semin. Arthritis Rheum. 36, 182–188 (2006)Article Google Scholar Andrianakos, A., Trontzas, P., Christoyannis, F., et al.: Prevalence of rheumatic diseases in Greece: a cross-sectional population-based epidemiological study. The ESORDIG Study. J. Rheumatol. 30, 1589–1601 (2003) Google Scholar Carmona, L., Villaverde, V., Hernandez-Garcia, C., et al.: The prevalence of rheumatoid arthritis in the general population of Spain. Rheumatology (Oxford) 41(1), 88–95 (2002)Article Google Scholar Cimmino, M.A., Parisi, M., Moggiana, G., et al.: Prevalence of rheumatoid arthritis in Italy: the Chiavari Study. Ann. Rheum. Dis. 57, 315–318 (1998) Google Scholar Drosos, A.A., Alamanos, I., Voulgari, P.V., et al.: Epidemiology of adult rheumatoid arthritis in northwest Greece 1987–1995. J. Rheumatol. 24, 2129–2133 (1997) Google Scholar Saraux, A., Guedes, C., Allain, J., et al.: Prevalence of rheumatoid arthritis and spondyloarthropathy in Brittany, France. Societe de Rhumatologie de l’Ouest J. Rheumatol. 26, 2622–2627 (1999) Google Scholar Gabriel, S.E., Crowson, C.S., O’Fallon, W.M.: The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955–1985. Arthritis Rheum. 42, 415–420 (1999)Article Google Scholar Hakala, M., Pollanen, R., Nieminen, P.: The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J. Rheumatol. 20, 1674–1678 (1993) Google Scholar Power, D., Codd, M., Ivers, L., et al.: Prevalence of rheumatoid arthritis in Dublin, Ireland: a population based survey. Ir. J. Med. Sci. 168, 197–200 (1999)Article Google Scholar Riise, T., Jacobsen, B.K., Gran, J.T.: Incidence and prevalence of rheumatoid arthritis in the county of Tromsö, northern Norway. J. Rheumatol. 27, 1386–1389 (2000) Google Scholar Simonsson, M., Bergman, S., Jacobsson, L.T., et al.: The prevalence of rheumatoid arthritis in Sweden. Scand. J. Rheumatol. 28, 340–343 (1999)Article Google Scholar Symmons, D., Turner, G., Webb, R., et al.: The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology (Oxford) 41, 793–800 (2002)Article Google Scholar Uhlig, T., Kvien, T.K., Glennas, A., et al.: The incidence and severity of rheumatoid arthritis, results from a county register in Oslo, Norway. J, Rheumatol, 25, 1078–1084 (1998) Google Scholar Rasch, E., Hirsch, R., Paulose-Ram, R., Hochberg, M.: Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification. Arthritis Rheum. 48, 917–926 (2003)Article Google Scholar Drosos, A., et al.: Rheumatoid Arthritis in Greek and British patients: a comparative clinical, radiologic, and serologic study. Arthritis Rheum. 35, 745–748 (1992)Article Google Scholar Antoni, C., Maini, R., Grunke, M., et al.: Cooperative of QoL in Rheumatic disease: results of a survey among 6,000 patients across 11 European countries. Arthritis Rheum 46:ACR (abstract) (2002)WHO Death and DALY estimates for 2002 by cause for WHO Member States, http://www.who.int/healthinfo/statistics/bodgbddeathdalyestimates.xls Rupp, I., Boshuizen, H.C., Dinant, H.J., et al.: Disability and health-related quality of life among patients with rheumatoid arthritis: association with radiographic joint damage, disease activity, pain, and depressive symptoms. Scand. J. Rheumatol. 35, 175–181 (2006)Article Google Scholar Young, A., Wilkinson, P., Talamo, J., et al.: Socioeconomic deprivation and rheumatoid disease. What lessons for the health service? Ann. Rheum. Dis. 59, 794–799 (2000)Article Google Scholar Kobelt, G., Lindgren, P., Lindroth, Y., Jacobson, L., Eberhardt, K.: Modelling the effect of function and disease activity on costs and quality of life in rheumatoid arthritis. Rheumatology (Oxford) 44, 1169–1175 (2005)Article Google Scholar Kobelt, G., Richard, B., Peeters, P., Sany, J.: Costs and quality of life of patients with RA in France. ACR 2006, Bone Joint Spine 75(7), (2008)Currie, C.J., McEwan, P., Peters, J.R., Patel, T.C., Dixon, S.: The routine collation of health outcomes data from hospital-treated subjects in the Health Outcomes Data Repository (HODaR): descriptive analysis from the first 20,000 subjects. Value Health 8, 581–590 (2005)Article Google Scholar Orme, M., Kerrigan, J., Tyas, D., Russell, N., Nixon, R.: The effect of disease, functional status and relapses ont he utility of people with multiple sclerosis in the UK. Value Health 10, 54–60 (2007)Article Google Scholar Bloom, B.S., Bruno, D.J., Maman, D.Y., Jayadevappa, R.: Usefulness of US cost-of-illness studies in healthcare decision making. Pharmacoeconomics 19, 207–213 (2001)Article Google Scholar Koopmanschap, M.A.: Cost-of-illness studies. Useful for health policy? Pharmacoeconomics 14, 143–148 (1998)Article Google Scholar Cooper, N.J.: Economic burden of rheumatoid arthritis: a systematic review. Rheumatology (Oxford) 39, 28–33 (2000)Article Google Scholar Pugner, K.M., Scott, D.I., Holmes, J.W., Hieke, K.: The costs of rheumatoid arthritis: an international long-term view. Semin. Arthritis Rheum. 29, 305–220 (2000)Article Google Scholar Rosery, H., Bergemann, R., Maxion-Bergemann, S.: International variation in resource utilisation and treatment costs for rheumatoid arthritis: a systematic literature review. Pharmacoeconomics 23, 243–257 (2005)Article Google Scholar Huscher, D., Merkesdal, S., Thiele, K., et al.: Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus in Germany. Ann. Rheum. Dis. 65, 1175–1183 (2006)Article Google Scholar Kirwan, J.R.: Conceptual issues in scoring radiographic progression in rheumatoid arthritis. J. Rheumatol. 26, 720–725 (1999) Google Scholar Landewe, R.B., Boers, M., Verhoeven, A.C., et al.: COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. Arthritis Rheum. 46, 347–356 (2002)Article Google Scholar Kobelt, G., Jonsson, L., Lindgren, P., et al.: Modeling the progression of rheumatoid arthritis: a two-country model to estimate costs and consequences of rheumatoid arthritis. Arthritis Rheum. 46, 2310–2319 (2002)Article Google Scholar Verstappen, S.M., Verkleij, H., Bijlsma, J.W., et al.: Determinants of direct costs in Dutch rheumatoid arthritis patients. Ann. Rheum. Dis. 63, 817–824 (2004)Article Google Scholar Hallert, E., Husberg, M., Skogh, T.: Costs and course of disease and function in early rheumatoid arthritis: a 3-year follow-up (the Swedish TIRA project). Rheumatology (Oxford) 45, 325–331 (2006)Article Google Scholar Michaud, K., Messer, J., Choi, H.K., Wolfe, F.: Direct medical costs and their predictors in patients with rheumatoid arthritis: a three-year study of 7,527 patients. Arthritis Rheum. 48, 2750–2762 (2003)Article Google Scholar Kobelt, G., Eberhardt, K., Jonsson, L., Jonsson, B.: Economic consequences of the progression of rheumatoid arthritis in Sweden. Arthritis Rheum. 42, 347–356 (1999)Article Google Scholar Hulsemann, J.L., Ruof, J., Zeidler, H., Mittendorf, T.: Costs in rheumatology: results and lessons learned from the ‘Hannover Costing Study’. Rheumatol. Int. 26, 704–711 (2006)Article Google Scholar Lajas, C., Abasolo, L., Bellajdel, B., et al.: Costs and predictors of costs in rheumatoid arthritis: a prevalence-based study. Arthritis Rheum. 49, 64–70 (2003)Article Google Scholar Albers, J.M., Kuper, H.H., van Riel, P.L., et al.: Socio-economic consequences of rheumatoid arthritis in the first years of the disease. Rheumatology (Oxford) 38, 423–430 (1999)Article Google Scholar Merkesdal, S., Ruof, J., Schoffski, O., et al.: Indirect medical costs in early rheumatoid arthritis: composition of and changes in indirect costs within the first three years of disease. Arthritis Rheum. 44, 528–534 (2001)Article Google Scholar Young, A., Dixey, J., Cox, N., et al.: How does functional disability in early rheumatoid arthritis (RA) affect patients and their lives? Results of 5 years of follow-up in 732 patients from the Early RA Study (ERAS). Rheumatology (Oxford) 39, 603–611 (2000)Article Google Scholar Fex, E., Larsson, B-M., Nived, K., Eberhardt, K.: Impact of rheumatoid arthritis on work status and social and leisure time activities in patients followed 8 years from onset. J. Rheumatol. 25, 44–50 (1997) Google Scholar Merkesdal, S., Huelsemann, J.L., Mittendorf, T., et al.: Productivity costs of rhumatoid arthritis in Germany: cost composition and prediction of main cost components (in German). Z. Rheumatol. 65, 527–534 (2006)Article Google Scholar Chorus, A.M., Miedema, H.S., Wevers, C.J., van Der Linden, S.: Labour force participation among patients with rheumatoid arthritis. Ann. Rheum. Dis. 59, 549–554 (2000)Article Google Scholar Young, A., Dixey, J., Kulinskaya, E., et al.: Which patients with early RA stop working? Results from a 5-year inception cohort of 547 patients. Ann. Rheum. Dis. 61, 335–340 (2002)Article Google Scholar Meenan, R.F., Yelin, E.H., Henke, C.J., et al.: The costs of rheumatoid arthritis. A patient-oriented study of chronic disease costs. Arthritis Rheum. 21, 827–833 (1978)Article Google Scholar Liang, M.H., Larson, M., Thompson, M., et al.: Costs and outcomes in rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 27, 522–529 (1984)Article Google Scholar Lubeck, D.P., Spitz, P.W., Fries, J.F., et al.: A multicenter study of annual health service utilization and costs in rheumatoid arthritis. Arthritis Rheum. 29, 488–493 (1986)Article Google Scholar Wolfe, F., Kleinheksel, S.M., Spitz, P.W., et al.: A multicenter study of hospitalization in rheumatoid arthritis. Frequency, medical-surgical admissions, and charges. Arthritis Rheum. 29, 614–619 (1986)Article Google Scholar Bloom, B.S.: Direct medical costs of disease and gastrointestinal side effects during treatment for arthritis. Am. J. Med. 84, 20–24 (1988)Article Google Scholar Gabriel, S.E., Crowson, C.S., Campion, M.E., O’Fallon, W.M.: Direct medical costs unique to people with arthritis. J. Rheumatol. 24, 719–725 (1997) Google Scholar Gabriel, S.E., Crowson, C.S., Campion, M.E., O’Fallon, W.M.: Indirect and nonmedical costs among people with rheumatoid arthritis and osteoarthritis compared with nonarthritic controls. J. Rheumatol. 24, 43–48 (1997) Google Scholar Lanes, S.F., Lanza, L.L., Radensky, P.W., et al.: Resource utilization and cost of care for rheumatoid arthritis and osteoarthritis in a managed care setting: the importance of drug and surgery costs. Arthritis Rheum. 40, 1475–1481 (1997)Article Google Scholar Ward, M.M., Javitz, H.S., Yelin, E.H.: The direct cost of rheumatoid arthritis. Value Health 3, 243–252 (2000)Article Google Scholar Yelin, E.: The costs of rheumatoid arthritis: absolute, incremental, and marginal estimates. J. Rheumatol. 44 (Suppl), 47–51 (1996) Google Scholar Yelin, E., Wanke, L.A.: An assessment of the annual and long-term direct costs of rheumatoid arthritis: the impact of poor function and functional decline. Arthritis Rheum. 42, 1209–1218 (1999)Article Google Scholar Andlin-Sobocki, P., Jonsson, B., Wittchen, H.U., Olesen, J.: Cost of disorders of the brain in Europe. Eur. J. Neurol. 12(Suppl 1), 1–27 (2005) Google Scholar OECD health data (2006) OECD GenevaEurostat (2006) Economy and finance, BrusselsThe Word Bank (2007) http://www.worldbank.org Kobelt, G., Berg, J., Lindgren, P., Fredrikson, S., Jönsson, B.: Costs and quality of life of multiple sclerosis in Europe. J. Neurol. Neurosurg. Psychiatry 77, 918–926 (2006)Article Google Scholar Wagner, E., Lackerbauer, E., Siegmeth, W.: Direct and indirect costs of rheumatoid arthritis and the socio-emotional effects of this disease—an Austrian study (in German). Wien Med Wochenschr 155, 217–226 (2005)Article Google Scholar Westhovens, R., Boonen, A., Verbruggen, L., et al.: Healthcare consumption and direct costs of rheumatoid arthritis in Belgium. Clin. Rheumatol. 24, 615–619 (2005)Article Google Scholar Maetzel, A., Li, L.C., Pencharz, J., et al.: The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann. Rheum. Dis. 63, 395–401 (2004)Article Google Scholar Sorensen, J.: Health care costs attributable to the treatment of rheumatoid arthritis. Scand. J. Rheumatol. 33, 399–404 (2004)Article Google Scholar Leardini, G., Salaffi, F., Montanelli, R., et al.: A multicenter cost-of-illness study on rheumatoid arthritis in Italy. Clin. Exp. Rheumatol. 20, 505–515 (2002) Google Scholar Verstappen, S.M., Jacobs, J.W., van der Heijde, D.M., et al.: Utility and direct costs: ankylosing spondylitis compared with rheumatoid arthritis. Ann. Rheum. Dis. (2006)Jacobsson, L.T., Lindroth, Y., Marsal, L., Juran, E., Bergstrom, U., Kobelt, G.: Rheumatoid arthritis: what does it cost and what factors are driving those costs? Results of a survey in a community-derived population in Malmo, Sweden. Scand. J. Rheumatol. 36, 179–183 (2007)Article Google Scholar Kobelt, G., Lindgren, P., Singh, A., Klareskog, L.: Cost effectiveness of etanercept (Enbrel) in combination with methotrexate in the treatment of active rheumatoid arthritis based on the TEMPO trial. Ann. Rheum. Dis. 64, 1174–1179 (2005)Article Google Scholar McIntosh, E.: The cost of rheumatoid arthritis. Br. J. Rheumatol. 35, 781–790 (1996)Article Google Scholar Sobocki, P., Pugliatti, M., Lauer, L., Kobelt, G.: Estimation of the cost of MS in Europe: extrapolations from a multinational cost study. Mult. Scler. 13, 1054–1064 (2007)Article Google Scholar Download references">

The burden of rheumatoid arthritis and access to treatment: health burden and costs

Author(s): Lundkvist J, Kastang F, Kobelt G

Abstract

As part of the study “The burden of rheumatoid arthritis and patient access to treatment”, this paper reviews evidence on the health burden of rheumatoid arthritis (RA) in terms of morbidity (DALYs), mortality (% of deaths attributable to RA) and quality of life (utility and loss of QALYs), as well as the economic impact on society. Based on available literature on the prevalence and the cost of RA, combined with economic indicators, the annual cost per patient as well as the total national cost is estimated for Europe and North America (Canada and the United States), as well as Australia, Turkey, the Russian Federation and South Africa. Total costs to society were estimated at €45.3 billion in Europe and at €41.6 billion in the United States. Utility scores were found to be amongst the lowest compared to other diseases.

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Silman, A.: Epidemiology of rheumatic diseases. Oxford University Press, Oxford (1993)

Google Scholar

Centers for Disease Control and Prevention: Prevalence of arthritis—US 1997. MMWR 50, 334–336, [CD] (2001)

Guillemin, F., Saraux, A., Guggenbuhl, P., et al.: Prevalence of rheumatoid arthritis in France: 2001. Ann. Rheum. Dis. 64, 1427–1430 (2005)

Article Google Scholar

Alamanos, Y., Voulgari, P.V., Drosos, A.A.: Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology Criteria: a systematic review. Semin. Arthritis Rheum. 36, 182–188 (2006)

Article Google Scholar

Andrianakos, A., Trontzas, P., Christoyannis, F., et al.: Prevalence of rheumatic diseases in Greece: a cross-sectional population-based epidemiological study. The ESORDIG Study. J. Rheumatol. 30, 1589–1601 (2003)

Google Scholar

Carmona, L., Villaverde, V., Hernandez-Garcia, C., et al.: The prevalence of rheumatoid arthritis in the general population of Spain. Rheumatology (Oxford) 41(1), 88–95 (2002)

Article Google Scholar

Cimmino, M.A., Parisi, M., Moggiana, G., et al.: Prevalence of rheumatoid arthritis in Italy: the Chiavari Study. Ann. Rheum. Dis. 57, 315–318 (1998)

Google Scholar

Drosos, A.A., Alamanos, I., Voulgari, P.V., et al.: Epidemiology of adult rheumatoid arthritis in northwest Greece 1987–1995. J. Rheumatol. 24, 2129–2133 (1997)

Google Scholar

Saraux, A., Guedes, C., Allain, J., et al.: Prevalence of rheumatoid arthritis and spondyloarthropathy in Brittany, France. Societe de Rhumatologie de l’Ouest J. Rheumatol. 26, 2622–2627 (1999)

Google Scholar

Gabriel, S.E., Crowson, C.S., O’Fallon, W.M.: The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955–1985. Arthritis Rheum. 42, 415–420 (1999)

Article Google Scholar

Hakala, M., Pollanen, R., Nieminen, P.: The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J. Rheumatol. 20, 1674–1678 (1993)

Google Scholar

Power, D., Codd, M., Ivers, L., et al.: Prevalence of rheumatoid arthritis in Dublin, Ireland: a population based survey. Ir. J. Med. Sci. 168, 197–200 (1999)

Article Google Scholar

Riise, T., Jacobsen, B.K., Gran, J.T.: Incidence and prevalence of rheumatoid arthritis in the county of Tromsö, northern Norway. J. Rheumatol. 27, 1386–1389 (2000)

Google Scholar

Simonsson, M., Bergman, S., Jacobsson, L.T., et al.: The prevalence of rheumatoid arthritis in Sweden. Scand. J. Rheumatol. 28, 340–343 (1999)

Article Google Scholar

Symmons, D., Turner, G., Webb, R., et al.: The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology (Oxford) 41, 793–800 (2002)

Article Google Scholar

Uhlig, T., Kvien, T.K., Glennas, A., et al.: The incidence and severity of rheumatoid arthritis, results from a county register in Oslo, Norway. J, Rheumatol, 25, 1078–1084 (1998)

Google Scholar

Rasch, E., Hirsch, R., Paulose-Ram, R., Hochberg, M.: Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification. Arthritis Rheum. 48, 917–926 (2003)

Article Google Scholar

Drosos, A., et al.: Rheumatoid Arthritis in Greek and British patients: a comparative clinical, radiologic, and serologic study. Arthritis Rheum. 35, 745–748 (1992)

Article Google Scholar

Antoni, C., Maini, R., Grunke, M., et al.: Cooperative of QoL in Rheumatic disease: results of a survey among 6,000 patients across 11 European countries. Arthritis Rheum 46:ACR (abstract) (2002)

WHO Death and DALY estimates for 2002 by cause for WHO Member States, http://www.who.int/healthinfo/statistics/bodgbddeathdalyestimates.xls

Rupp, I., Boshuizen, H.C., Dinant, H.J., et al.: Disability and health-related quality of life among patients with rheumatoid arthritis: association with radiographic joint damage, disease activity, pain, and depressive symptoms. Scand. J. Rheumatol. 35, 175–181 (2006)

Article Google Scholar

Young, A., Wilkinson, P., Talamo, J., et al.: Socioeconomic deprivation and rheumatoid disease. What lessons for the health service? Ann. Rheum. Dis. 59, 794–799 (2000)

Article Google Scholar

Kobelt, G., Lindgren, P., Lindroth, Y., Jacobson, L., Eberhardt, K.: Modelling the effect of function and disease activity on costs and quality of life in rheumatoid arthritis. Rheumatology (Oxford) 44, 1169–1175 (2005)

Article Google Scholar

Kobelt, G., Richard, B., Peeters, P., Sany, J.: Costs and quality of life of patients with RA in France. ACR 2006, Bone Joint Spine 75(7), (2008)

Currie, C.J., McEwan, P., Peters, J.R., Patel, T.C., Dixon, S.: The routine collation of health outcomes data from hospital-treated subjects in the Health Outcomes Data Repository (HODaR): descriptive analysis from the first 20,000 subjects. Value Health 8, 581–590 (2005)

Article Google Scholar

Orme, M., Kerrigan, J., Tyas, D., Russell, N., Nixon, R.: The effect of disease, functional status and relapses ont he utility of people with multiple sclerosis in the UK. Value Health 10, 54–60 (2007)

Article Google Scholar

Bloom, B.S., Bruno, D.J., Maman, D.Y., Jayadevappa, R.: Usefulness of US cost-of-illness studies in healthcare decision making. Pharmacoeconomics 19, 207–213 (2001)

Article Google Scholar

Koopmanschap, M.A.: Cost-of-illness studies. Useful for health policy? Pharmacoeconomics 14, 143–148 (1998)

Article Google Scholar

Cooper, N.J.: Economic burden of rheumatoid arthritis: a systematic review. Rheumatology (Oxford) 39, 28–33 (2000)

Article Google Scholar

Pugner, K.M., Scott, D.I., Holmes, J.W., Hieke, K.: The costs of rheumatoid arthritis: an international long-term view. Semin. Arthritis Rheum. 29, 305–220 (2000)

Article Google Scholar

Rosery, H., Bergemann, R., Maxion-Bergemann, S.: International variation in resource utilisation and treatment costs for rheumatoid arthritis: a systematic literature review. Pharmacoeconomics 23, 243–257 (2005)

Article Google Scholar

Huscher, D., Merkesdal, S., Thiele, K., et al.: Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus in Germany. Ann. Rheum. Dis. 65, 1175–1183 (2006)

Article Google Scholar

Kirwan, J.R.: Conceptual issues in scoring radiographic progression in rheumatoid arthritis. J. Rheumatol. 26, 720–725 (1999)

Google Scholar

Landewe, R.B., Boers, M., Verhoeven, A.C., et al.: COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. Arthritis Rheum. 46, 347–356 (2002)

Article Google Scholar

Kobelt, G., Jonsson, L., Lindgren, P., et al.: Modeling the progression of rheumatoid arthritis: a two-country model to estimate costs and consequences of rheumatoid arthritis. Arthritis Rheum. 46, 2310–2319 (2002)

Article Google Scholar

Verstappen, S.M., Verkleij, H., Bijlsma, J.W., et al.: Determinants of direct costs in Dutch rheumatoid arthritis patients. Ann. Rheum. Dis. 63, 817–824 (2004)

Article Google Scholar

Hallert, E., Husberg, M., Skogh, T.: Costs and course of disease and function in early rheumatoid arthritis: a 3-year follow-up (the Swedish TIRA project). Rheumatology (Oxford) 45, 325–331 (2006)

Article Google Scholar

Michaud, K., Messer, J., Choi, H.K., Wolfe, F.: Direct medical costs and their predictors in patients with rheumatoid arthritis: a three-year study of 7,527 patients. Arthritis Rheum. 48, 2750–2762 (2003)

Article Google Scholar

Kobelt, G., Eberhardt, K., Jonsson, L., Jonsson, B.: Economic consequences of the progression of rheumatoid arthritis in Sweden. Arthritis Rheum. 42, 347–356 (1999)

Article Google Scholar

Hulsemann, J.L., Ruof, J., Zeidler, H., Mittendorf, T.: Costs in rheumatology: results and lessons learned from the ‘Hannover Costing Study’. Rheumatol. Int. 26, 704–711 (2006)

Article Google Scholar

Lajas, C., Abasolo, L., Bellajdel, B., et al.: Costs and predictors of costs in rheumatoid arthritis: a prevalence-based study. Arthritis Rheum. 49, 64–70 (2003)

Article Google Scholar

Albers, J.M., Kuper, H.H., van Riel, P.L., et al.: Socio-economic consequences of rheumatoid arthritis in the first years of the disease. Rheumatology (Oxford) 38, 423–430 (1999)

Article Google Scholar

Merkesdal, S., Ruof, J., Schoffski, O., et al.: Indirect medical costs in early rheumatoid arthritis: composition of and changes in indirect costs within the first three years of disease. Arthritis Rheum. 44, 528–534 (2001)

Article Google Scholar

Young, A., Dixey, J., Cox, N., et al.: How does functional disability in early rheumatoid arthritis (RA) affect patients and their lives? Results of 5 years of follow-up in 732 patients from the Early RA Study (ERAS). Rheumatology (Oxford) 39, 603–611 (2000)

Article Google Scholar

Fex, E., Larsson, B-M., Nived, K., Eberhardt, K.: Impact of rheumatoid arthritis on work status and social and leisure time activities in patients followed 8 years from onset. J. Rheumatol. 25, 44–50 (1997)

Google Scholar

Merkesdal, S., Huelsemann, J.L., Mittendorf, T., et al.: Productivity costs of rhumatoid arthritis in Germany: cost composition and prediction of main cost components (in German). Z. Rheumatol. 65, 527–534 (2006)

Article Google Scholar

Chorus, A.M., Miedema, H.S., Wevers, C.J., van Der Linden, S.: Labour force participation among patients with rheumatoid arthritis. Ann. Rheum. Dis. 59, 549–554 (2000)

Article Google Scholar

Young, A., Dixey, J., Kulinskaya, E., et al.: Which patients with early RA stop working? Results from a 5-year inception cohort of 547 patients. Ann. Rheum. Dis. 61, 335–340 (2002)

Article Google Scholar

Meenan, R.F., Yelin, E.H., Henke, C.J., et al.: The costs of rheumatoid arthritis. A patient-oriented study of chronic disease costs. Arthritis Rheum. 21, 827–833 (1978)

Article Google Scholar

Liang, M.H., Larson, M., Thompson, M., et al.: Costs and outcomes in rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 27, 522–529 (1984)

Article Google Scholar

Lubeck, D.P., Spitz, P.W., Fries, J.F., et al.: A multicenter study of annual health service utilization and costs in rheumatoid arthritis. Arthritis Rheum. 29, 488–493 (1986)

Article Google Scholar

Wolfe, F., Kleinheksel, S.M., Spitz, P.W., et al.: A multicenter study of hospitalization in rheumatoid arthritis. Frequency, medical-surgical admissions, and charges. Arthritis Rheum. 29, 614–619 (1986)

Article Google Scholar

Bloom, B.S.: Direct medical costs of disease and gastrointestinal side effects during treatment for arthritis. Am. J. Med. 84, 20–24 (1988)

Article Google Scholar

Gabriel, S.E., Crowson, C.S., Campion, M.E., O’Fallon, W.M.: Direct medical costs unique to people with arthritis. J. Rheumatol. 24, 719–725 (1997)

Google Scholar

Gabriel, S.E., Crowson, C.S., Campion, M.E., O’Fallon, W.M.: Indirect and nonmedical costs among people with rheumatoid arthritis and osteoarthritis compared with nonarthritic controls. J. Rheumatol. 24, 43–48 (1997)

Google Scholar

Lanes, S.F., Lanza, L.L., Radensky, P.W., et al.: Resource utilization and cost of care for rheumatoid arthritis and osteoarthritis in a managed care setting: the importance of drug and surgery costs. Arthritis Rheum. 40, 1475–1481 (1997)

Article Google Scholar

Ward, M.M., Javitz, H.S., Yelin, E.H.: The direct cost of rheumatoid arthritis. Value Health 3, 243–252 (2000)

Article Google Scholar

Yelin, E.: The costs of rheumatoid arthritis: absolute, incremental, and marginal estimates. J. Rheumatol. 44 (Suppl), 47–51 (1996)

Google Scholar

Yelin, E., Wanke, L.A.: An assessment of the annual and long-term direct costs of rheumatoid arthritis: the impact of poor function and functional decline. Arthritis Rheum. 42, 1209–1218 (1999)

Article Google Scholar

Andlin-Sobocki, P., Jonsson, B., Wittchen, H.U., Olesen, J.: Cost of disorders of the brain in Europe. Eur. J. Neurol. 12(Suppl 1), 1–27 (2005)

Google Scholar

OECD health data (2006) OECD Geneva

Eurostat (2006) Economy and finance, Brussels

The Word Bank (2007) http://www.worldbank.org

Kobelt, G., Berg, J., Lindgren, P., Fredrikson, S., Jönsson, B.: Costs and quality of life of multiple sclerosis in Europe. J. Neurol. Neurosurg. Psychiatry 77, 918–926 (2006)

Article Google Scholar

Wagner, E., Lackerbauer, E., Siegmeth, W.: Direct and indirect costs of rheumatoid arthritis and the socio-emotional effects of this disease—an Austrian study (in German). Wien Med Wochenschr 155, 217–226 (2005)

Article Google Scholar

Westhovens, R., Boonen, A., Verbruggen, L., et al.: Healthcare consumption and direct costs of rheumatoid arthritis in Belgium. Clin. Rheumatol. 24, 615–619 (2005)

Article Google Scholar

Maetzel, A., Li, L.C., Pencharz, J., et al.: The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann. Rheum. Dis. 63, 395–401 (2004)

Article Google Scholar

Sorensen, J.: Health care costs attributable to the treatment of rheumatoid arthritis. Scand. J. Rheumatol. 33, 399–404 (2004)

Article Google Scholar

Leardini, G., Salaffi, F., Montanelli, R., et al.: A multicenter cost-of-illness study on rheumatoid arthritis in Italy. Clin. Exp. Rheumatol. 20, 505–515 (2002)

Google Scholar

Verstappen, S.M., Jacobs, J.W., van der Heijde, D.M., et al.: Utility and direct costs: ankylosing spondylitis compared with rheumatoid arthritis. Ann. Rheum. Dis. (2006)

Jacobsson, L.T., Lindroth, Y., Marsal, L., Juran, E., Bergstrom, U., Kobelt, G.: Rheumatoid arthritis: what does it cost and what factors are driving those costs? Results of a survey in a community-derived population in Malmo, Sweden. Scand. J. Rheumatol. 36, 179–183 (2007)

Article Google Scholar

Kobelt, G., Lindgren, P., Singh, A., Klareskog, L.: Cost effectiveness of etanercept (Enbrel) in combination with methotrexate in the treatment of active rheumatoid arthritis based on the TEMPO trial. Ann. Rheum. Dis. 64, 1174–1179 (2005)

Article Google Scholar

McIntosh, E.: The cost of rheumatoid arthritis. Br. J. Rheumatol. 35, 781–790 (1996)

Article Google Scholar

Sobocki, P., Pugliatti, M., Lauer, L., Kobelt, G.: Estimation of the cost of MS in Europe: extrapolations from a multinational cost study. Mult. Scler. 13, 1054–1064 (2007)

Article Google Scholar

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