Author(s): McCrone P, Chisholm D, Knapp M, Hughes R, Comi G, et al.
The aim of this study was to provide an incremental cost-effectiveness analysis comparing intravenous immunoglobulin (IVIg) and prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy. Patients were recruited to a double-blind randomized crossover trial from nine European centres and received either prednisolone or IVIg during the first 6-week treatment period on which the economic evaluation was based. A societal perspective was adopted in measuring service use and costs, although the costs of lost employment were not included. The main outcome measure in the economic evaluation was the number of quality adjusted life years (QALYs) gained, with change in a 11-point disability scale used to measure clinical outcomes. Service use and quality of life data were available for 25 patients. Baseline costs were controlled for using a bootstrapped multiple regression model. The cost difference between the two treatments was estimated to be euro 3754 over the 6-week period. Health-related quality of life, as measured by the EuroQol EQ-5D instrument, increased more in the IVIg group but the difference was not statistically significant. Using a net-benefit approach it was shown that the probability of IVIg being cost-effective in comparison with prednisolone was 0.5 or above (i.e. was more likely to be cost-effective than cost-ineffective) only if one QALY was valued at over euro 250 000. The cost-effectiveness of IVIg is greatly affected by the price of IVIg and the amount administered. The impact of later side-effects of prednisolone on long-term costs and quality of life are likely to reduce the cost per QALY of IVIg treatment.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/14641514
Author(s): Caro XJ, Winter EF, Dumas AJ
Author(s): Bednarík J, Kadanka Z
Author(s): Ahmed AR, Dahl MV
Author(s): Gurcan HM, Ahmed AR
Author(s): Katz U, Achiron A, Sherer Y, Shoenfeld Y
Author(s): Orbach H, Katz U, Sherer Y, Shoenfeld Y
Author(s): Ruetter A, Luger TA
Author(s): Brannagan TH 3rd, Nagle KJ, Lange DJ, Rowland LP
Author(s): Chamouni P, Tamion F, Gueit I, Girault C, Lenain P, et al.
Author(s): Wittstock M, Benecke R, Zettl UK
Author(s): Hughes RA, Donofrio P, Bril V, Dalakas MC, Deng C, et al.
Author(s): Brannagan TH 3rd
Author(s): Guptill JT, Bromberg MB, Zhu L, Sharma BK, Thompson AR, et al.
Author(s): Pedrosa RP, Barros IM, Drager LF, Bittencourt MS, Medeiros AK, et al.
Author(s): Russell IJ, Larson AA
Author(s): Jessop DS, Renshaw D, Larsen PJ, Chowdrey HS, Harbuz MS
Author(s): Larsen PJ, Jessop D, Patel H, Lightman SL, Chowdrey HS
Author(s): Donaldson CC, Snelling LS, MacInnis AL, Sella GE, Mueller HH
Author(s): Arnold LM, Rosen A, Pritchett YL, D'Souza DN, Goldstein DJ, et al.
Author(s): Kim L, Lipton S, Deodhar A
Author(s): Moldofsky HK
Author(s): Moldofsky H, Inhaber NH, Guinta DR, Varez-Horine SB
Author(s): Russell IJ, Crofford LJ, Leon T, Cappelleri JC, Bushmakin AG, et al.
Author(s): Rosenfeld VW, Rutledge DN, Stern JM
Author(s): Ahles TA, Khan SA, Yunus MB, Spiegel DA, Masi AT
Author(s): Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, et al.
Author(s): Katz RS, Wolfe F, Michaud K
Author(s): Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, et al.
Author(s): Valencia-Flores M, Cardiel MH, Santiago V, Resendiz M, Castaño VA, et al.
Author(s): Giovengo SL, Russell IJ, Larson AA
Author(s): Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L
Author(s): White KP, Harth M
Author(s): Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, et al.
Author(s): Clark P, Burgos-Vargas R, Medina-Palma C, Lavielle P, Marina FF
Author(s): Goldenberg DL, Burckhardt C, Crofford L
Author(s): Carville SF, Choy EH
Author(s): Perrot S, Russell IJ
Author(s): Mease P, Arnold LM, Choy EH, Clauw DJ, Crofford LJ, et al.
Author(s): Mease PJ, Clauw DJ, Christensen R, Crofford LJ, Gendreau RM, et al.
Author(s): Kuwahara M, Suzuki S, Takada K, Kusunoki S
Author(s): Kerasnoudis A, Pitarokoili K, Behrendt V, Gold R, Yoon MS
Author(s): Zhang HL, Zhang XM, Mao XJ, Deng H, Li HF, et al.
Author(s): Eldar AH, Chapman J
Author(s): Dalakas MC; Medscape
Author(s): Boukhris S, Magy L, Khalil M, Sindou P, Vallat JM
Author(s): Westblad ME, Forsberg A, Press R
Author(s): Latov N, Deng C, Dalakas MC, Bril V, Donofrio P, et al.
Author(s): Latov N
Author(s): Joint Task Force of the EFNS and the PNS
Author(s): Hughes R, Bensa S, Willison H, Van den Bergh P, Comi G, et al.
Author(s): Magda P, Latov N, Brannagan TH 3rd, Weimer LH, Chin RL, et al.
Author(s): Thaisetthawatkul P, Logigian EL, Herrmann DN
Author(s): Saperstein DS, Katz JS, Amato AA, Barohn RJ
Author(s): Barohn RJ, Kissel JT, Warmolts JR, Mendell JR
Author(s): Dyck PJ, Lais AC, Ohta M, Bastron JA, Okazaki H, et al.
Author(s): Koski CL, Baumgarten M, Magder LS, Barohn RJ, Goldstein J, et al.
Author(s): Magy L, Mathis S, Vallat JM
Author(s): Rajabally YA, Nicolas G, Piéret F, Bouche P, Van den Bergh PY
Author(s): Rajabally YA, Simpson BS, Beri S, Bankart J, Gosalakkal JA
Author(s): Dalakas MC
Author(s): Ritter C, Förster D, Albrecht P, Hartung HP, Kieseier BC, et al.
Author(s): Bedi G, Brown A, Tong T, Sharma KR
Author(s): Cocito D, Grimaldi S, Paolasso I, Falcone Y, Antonini G, et al.
Author(s): Mahdi-Rogers M, Swan AV, van Doorn PA, Hughes RA
Author(s): Bright RJ, Wilkinson J, Coventry BJ
Author(s): Boukhris S, Magy L, Gallouedec G, Khalil M, Couratier P, et al.
Author(s): Dionne A, Nicolle MW, Hahn AF
Author(s): Viola-Saltzman M, Watson NF, Bogart A, Goldberg J, Buchwald D