Author(s): Henrotin Y, Kurz B, Aigner T
Objectives:This review is focused on the influence of oxygen and derived reactive species on chondrocytes aging, metabolic function and chondrogenic phenotype.
Methods:A systematic computer-aided search of the Medline database.
Results:Articular cartilage is an avascular tissue, and consequently oxygen supply is reduced. Although the basal metabolic functions of the cells are well adapted to hypoxia, the chondrocyte phenotype seems to be oxygen sensitive. In vitro, hypoxia promotes the expression of the chondrogenic phenotype and cartilage-specific matrix formation, indicating that oxygen tension is probably a key parameter in chondrocyte culture, and particularly in the context of tissue engineering and stem cells transplantation. Besides the influence of oxygen itself, reactive oxygen species (ROS) play a crucial role in the regulation of a number of basic chondrocyte activities such as cell activation, proliferation and matrix remodeling. However, when ROS production exceeds the antioxidant capacities of the cell, an "oxidative stress" occurs leading to structural and functional cartilage damages like cell death and matrix degradation.
Conclusions:This paper is an overview of the in vitro and in vivo studies published on the influence of oxygen and derived reactive species on chondrocyte aging, metabolic function, and the chondrogenic phenotype. It shows, that oxygen and ROS play a crucial role in the control of cartilage homeostasis and that at this time, the exact role of "oxidative stress" in cartilage degradation still remains questionable.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/15936958
Author(s): Feldmann M, Brennan FM, Maini RN
Author(s): Jaswal S, Mehta HC, Sood AK, Kaur J
Author(s): Demirbag R, Yilmaz R, Erel O, Gultekin U, Asci D, et al.
Author(s): Ozgocmen S, Ozyurt H, Sogut S, Akyol O
Author(s): Blake DR, Hall ND, Treby DA, Halliwell B, Gutteridge JM
Author(s): Heliövaara M, Knekt P, Aho K, Aaran RK, Alfthan G, et al.
Author(s): Mazzetti I, Grigolo B, Borzì RM, Meliconi R, Facchini A
Author(s): Shah ZA, Vohora SB
Author(s): Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, et al.
Author(s): Gutteridge JM
Author(s): Ali AM, Habeeb RA, El-Azizi NO, Khattab DA, Abo-Shady RA, et al.
Author(s): Kamanli A, Naziroqlu M, Aydilek N, Hacievliyagil C
Author(s): Sarban S, Kocyigit A, Yazar M, Isikan UE
Author(s): Hassan MQ, Hadi RA, Al-Rawi ZS, Padron VA, Stohs SJ
Author(s): Afonso V, Champy R, Mitrovic D, Collin P, Lomri A
Author(s): Mirshafiey A, Mohsenzadegan M
Author(s): McCord JM
Author(s): Gambhir JK, Lali P, Jain AK
Author(s): Mishra R, Singh A, Chandra V, Negi MP, Tripathy BC, et al.
Author(s): Pallinti V, Ganesan N, Anbazhagan M, Rajasekhar G
Author(s): Thiele GM, Duryee MJ, Anderson DR, Klassen LW, Mohring SM, et al.
Author(s): Armagan A, Uzar E, Uz E, Yilmaz HR, Kutluhan S, et al.
Author(s): Al-Saleh E, Al-Harmi J, Nandakumaran M, Al-Shammari M, Al-Jassar W
Author(s): Vijayakumar D, Suresh K, Manoharan S
Author(s): Cimen MY, Cimen OB, Kacmaz M, Ozturk HS, Yorgancioglu R, et al.
Author(s): Gregory EM, Fridovich I
Author(s): Sung JY, Hong JH, Kang HS, Choi I, Lim SD, et al.
Author(s): Lin MT, Beal MF
Author(s): Zaghloul N, Patel H, Codipilly C, Marambaud P, Dewey S, et al.
Author(s): Igari T, Kaneda H, Horiuchi S, Ono S
Author(s): Mateen S, Moin S, Khan AQ, Zafar A, Fatima N
Author(s): Taysi S, Polat F, Gul M, Sari RA, Bakan E
Author(s): Veselinovic M, Barudzic N, Vuletic M, Zivkovic V, Tomic-Lucic A, et al.
Author(s): Benhamou PY, Moriscot C, Richard MJ, Beatrix O, Badet L, et al.
Author(s): García-González A, Gaxiola-Robles R, Zenteno-Savín T
Author(s): Feijóo M, Túnez I, Ruiz A, Tasset I, Muñoz E, et al.
Author(s): Evelo CTA, Palmen NGM, Artur Y, Janssen GME
Author(s): Bazzichi L, Ciompi ML, Betti L, Rossi A, Melchiorre D, et al.
Author(s): Kerimova AA, Atalay M, Yusifov EY, Kuprin SP, Kerimov TM
Author(s): Mulherin DM, Thurnham DI, Situnayake RD
Author(s): Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, et al.
Author(s): Gum JR, Hicks JW, Sack TL, Kim YS
Author(s): Thompson PW, Houghton BJ, Clifford C, Jones DD, Whitaker KB, et al.
Author(s): Nanke Y, Kotake S, Akama H, Kamatani N
Author(s): Spooner RJ, Smith DH, Bedford D, Beck PR
Author(s): Paredes S, Girona J, Hurt-Camejo E, Vallvé JC, Olivé S, et al.
Author(s): Jalili M, Kolahi S, Aref-Hosseini SR, Mamegani ME, Hekmatdoost A