Author(s): Mazzetti I, Grigolo B, Borzì RM, Meliconi R, Facchini A
Rheumatoid arthritis is characterized by a chronic hypertrophic synovitis leading to destruction of connective tissue and functional damage of cartilage and bone structures. Reactive oxygen species play an important role in tissue injury in this disease. To clarify the role of the cellular antioxidant system in the protection against oxygen free radicals, we examined the levels of copper/zinc superoxide dismutase in the sera of patients with rheumatoid arthritis. We used an enzyme-linked immunosorbent assay which determines the concentration of copper/zinc superoxide dismutase independently from its enzymatic activity. We found that patients with rheumatoid arthritis have higher serum copper/zinc superoxide dismutase levels than control subjects. Copper/zinc superoxide dismutase also correlated positively with serum levels of both neopterin and rheumatoid factor, sensitive markers for disease activity in rheumatoid arthritis. These results support the hypothesis that the increased amount of copper/zinc superoxide dismutase is probably inadequate to exert an effective antioxidant protection but can result in a pro-inflammatory, pathogenic effect enhancing tissue damage. Furthermore, copper/zinc superoxide dismutase might be used as a marker of inflammatory activity in rheumatoid arthritis.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/9007615
Author(s): Feldmann M, Brennan FM, Maini RN
Author(s): Jaswal S, Mehta HC, Sood AK, Kaur J
Author(s): Demirbag R, Yilmaz R, Erel O, Gultekin U, Asci D, et al.
Author(s): Ozgocmen S, Ozyurt H, Sogut S, Akyol O
Author(s): Henrotin Y, Kurz B, Aigner T
Author(s): Blake DR, Hall ND, Treby DA, Halliwell B, Gutteridge JM
Author(s): Heliövaara M, Knekt P, Aho K, Aaran RK, Alfthan G, et al.
Author(s): Shah ZA, Vohora SB
Author(s): Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, et al.
Author(s): Gutteridge JM
Author(s): Ali AM, Habeeb RA, El-Azizi NO, Khattab DA, Abo-Shady RA, et al.
Author(s): Kamanli A, Naziroqlu M, Aydilek N, Hacievliyagil C
Author(s): Sarban S, Kocyigit A, Yazar M, Isikan UE
Author(s): Hassan MQ, Hadi RA, Al-Rawi ZS, Padron VA, Stohs SJ
Author(s): Afonso V, Champy R, Mitrovic D, Collin P, Lomri A
Author(s): Mirshafiey A, Mohsenzadegan M
Author(s): McCord JM
Author(s): Gambhir JK, Lali P, Jain AK
Author(s): Mishra R, Singh A, Chandra V, Negi MP, Tripathy BC, et al.
Author(s): Pallinti V, Ganesan N, Anbazhagan M, Rajasekhar G
Author(s): Thiele GM, Duryee MJ, Anderson DR, Klassen LW, Mohring SM, et al.
Author(s): Armagan A, Uzar E, Uz E, Yilmaz HR, Kutluhan S, et al.
Author(s): Al-Saleh E, Al-Harmi J, Nandakumaran M, Al-Shammari M, Al-Jassar W
Author(s): Vijayakumar D, Suresh K, Manoharan S
Author(s): Cimen MY, Cimen OB, Kacmaz M, Ozturk HS, Yorgancioglu R, et al.
Author(s): Gregory EM, Fridovich I
Author(s): Sung JY, Hong JH, Kang HS, Choi I, Lim SD, et al.
Author(s): Lin MT, Beal MF
Author(s): Zaghloul N, Patel H, Codipilly C, Marambaud P, Dewey S, et al.
Author(s): Igari T, Kaneda H, Horiuchi S, Ono S
Author(s): Mateen S, Moin S, Khan AQ, Zafar A, Fatima N
Author(s): Taysi S, Polat F, Gul M, Sari RA, Bakan E
Author(s): Veselinovic M, Barudzic N, Vuletic M, Zivkovic V, Tomic-Lucic A, et al.
Author(s): Benhamou PY, Moriscot C, Richard MJ, Beatrix O, Badet L, et al.
Author(s): García-González A, Gaxiola-Robles R, Zenteno-Savín T
Author(s): Feijóo M, Túnez I, Ruiz A, Tasset I, Muñoz E, et al.
Author(s): Evelo CTA, Palmen NGM, Artur Y, Janssen GME
Author(s): Bazzichi L, Ciompi ML, Betti L, Rossi A, Melchiorre D, et al.
Author(s): Kerimova AA, Atalay M, Yusifov EY, Kuprin SP, Kerimov TM
Author(s): Mulherin DM, Thurnham DI, Situnayake RD
Author(s): Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, et al.
Author(s): Gum JR, Hicks JW, Sack TL, Kim YS
Author(s): Thompson PW, Houghton BJ, Clifford C, Jones DD, Whitaker KB, et al.
Author(s): Nanke Y, Kotake S, Akama H, Kamatani N
Author(s): Spooner RJ, Smith DH, Bedford D, Beck PR
Author(s): Paredes S, Girona J, Hurt-Camejo E, Vallvé JC, Olivé S, et al.
Author(s): Jalili M, Kolahi S, Aref-Hosseini SR, Mamegani ME, Hekmatdoost A