Author(s): Wolfe F, Mitchell DM, Sibley JT, Fries JF, Bloch DA, et al.
Objective:To determine the risk and causes of death and to quantify mortality predictors in patients with rheumatoid arthritis (RA).
Methods:RA patients (n = 3,501) from 4 centers (Saskatoon n = 905, Wichita n = 1,405, Stanford n = 886, and Santa Clara n = 305) were followed for up to 35 years; 922 patients died.
Results:The overall standardized mortality ratio (SMR) was 2.26 (Saskatoon 2.24, Wichita 1.98, Stanford 3.08, Santa Clara 2.18) and increased with time. Mortality was strikingly increased for specific causes: infection, lymphoproliferative malignancy, gastroenterologic, and RA. In addition, as an effect of the SMR of 2.26, the expected number of deaths was increased nonspecifically across all causes (except cancer), with a large excess of deaths attributable to cardiovascular and cerebrovascular diseases. Independent predictors of mortality included age, education, male sex, function, rheumatoid factor, nodules, erythrocyte sedimentation rate, joint count, and prednisone use.
Conclusion:Mortality rates are increased at least 2-fold in RA, and are linked to clinical severity.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/8147925
Author(s): Maradit-Kremers H, Nicola PJ, Crowson CS, Ballman KV, Gabriel SE
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Author(s): Bakker MF, Jacobs JW, Verstappen SM, Bijlsma JW
Author(s): Choi HK, Hernán MA, Seeger JD, Robins JM, Wolfe F
Author(s): Toyoshima H, Kusaba T, Yamaguchi M
Author(s): Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, et al.
Author(s): Laakso M, Isomäki H, Mutru O, Koota K
Author(s): Lachmann HJ, Goodman HJ, Gilbertson JA, Gallimore JR, Sabin CA, et al.
Author(s): Matsuda Y, Singh G, Yamanaka H, Tanaka E, Urano W, et al.
Author(s): Yamanaka H, Tohma S
Author(s): Mutru O, Laakso M, Isomäki H, Koota K
