Biodegradable Intrascleral Implant for SustainedIntraocular Delivery of Betamethasone Phosphate

Author(s): Okabe J, Kimura H, Kunou N, OkabeK, Kato A, et al.


purpose. To evaluate the feasibility of using a biodegradable intrascleral implant for intraocular sustained delivery of betamethasone phosphate (BP).

methods. The intrascleral implant (0.5 mm thick and 4 mm in diameter) was made of poly(dl-lactide) containing 25% betamethasone phosphate. The in vitro release of BP from the implant was evaluated by high-performance liquid chromatography (HPLC). The implants were placed into a scleral pocket in the rabbit’s eye. The concentrations of BP in the aqueous humor, vitreous, and retina-choroid were measured by HPLC. The toxicity and biocompatibility of the implant were evaluated by slit lamp examination, electroretinography, and light microscopy.

results. In vitro studies demonstrated that the implants released BP in a biphasic pattern for at least 8 weeks. The BP concentrations in the vitreous and the retina-choroid remained within the concentration range capable of suppressing inflammatory responses for more than 8 weeks. The BP concentration was greater in the retina-choroid than in the vitreous. In the aqueous humor, BP was below the detection limit during the observation period. No significant toxicity to the retina was observed. Also, the implant showed good biocompatibility in the eye.

conclusions. These results suggest that the intrascleral implant would be a promising system for delivery of steroid to the posterior segment of the eye.

Similar Articles

Drug delivery to the posterior segment of the eye

Author(s): Lee TWY, RobinsonJR

Development andevaluation of prolonged release topical indomethacin formulations for ocularinflammation

Author(s): AdelliGR, Balguri SP, Punyamurthula N, Bhagav P, Majumdar S

Theblood-ocular barriers

Author(s): Cunha-Vaz J

Drug delivery to the retina: challenges and opportunities

Author(s): Duvvuri S,Majumdar S, Mitra AK

Ocularpreparations: the formulation approach

Author(s): Kaur IP, Kanwar M

Evaluation of topical hesperetin matrix filmfor back-of-the-eye delivery

Author(s): Adelli GR, Hingorani T, PunyamurthulaN, Balguri SP, Majumdar S

Ocular inserts - Advancement in therapy of eye diseases

Author(s): Kumari A, Sharma PK, Garg VK,Garg G

Ocular inserts for topical delivery

Author(s): SaettoneFM, Salminen L

Stability of benzocaine formulated in commercialoral disintegrating tablet platforms

Author(s): Köllmer M, Popescu C, Manda P,Zhou L, Gemeinhart RA

New methods of drug delivery

Author(s): Langer R

Iontophoretic drug delivery for the treatment ofscars

Author(s): Manda P, Angamuthu M, HiremathSR, Raman V, Murthy SN

Polysulfone capillary fiber forintraocular drug delivery: in vitro and in vivo evaluations

Author(s): Rahimy MH, PeymanGA, Chin SY, Golshani R, Aras C, et al.

Intravitreal sustained-releaseganciclovir

Author(s): Smith TJ, Pearson PA, BlandfordDL, Brown JD, Goins KA, et al.

Delivery of cefotaxime to the brain viaintranasal administration

Author(s): Manda P, Hargett JK, Kiran Vaka SR,Repka MA, Narasimha Murthy S

Delivery of ziconotide to cerebrospinalfluid via intranasal pathway for the treatment of chronic pain

Author(s): Manda P, Kushwaha AS, Kundu S,Shivakumar H, Jo SB, et al.

Episcleral implants for topotecandelivery to the posterior segment of the eye

Author(s): Carcaboso AM, Chiappetta DA,Opezzo JA, Höcht C, Fandiño AC, et al.