Intravitreal sustained-releaseganciclovir

Author(s): Smith TJ, Pearson PA, BlandfordDL, Brown JD, Goins KA, et al.

Abstract

Current treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome involves frequent intravenous administration of sodium ganciclovir that often results in unacceptable side effects. We have developed devices that release ganciclovir at rates of 2 μg/h and 5 μg/h in vitro. When implanted into the vitreous of rabbit eyes, mean intravitreal ganciclovir levels of 9 mg/L and 16 mg/L were maintained for more than 80 and 42 days, respectively. Devices were well tolerated, with no toxic effects attributable to the polymers used in the devices. This investigation indicates that these devices can maintain therapeutic levels of drug for extended periods and are well tolerated in the rabbit eye. They may prove useful in the clinical management of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome.

Similar Articles

Drug delivery to the posterior segment of the eye

Author(s): Lee TWY, RobinsonJR

Development andevaluation of prolonged release topical indomethacin formulations for ocularinflammation

Author(s): AdelliGR, Balguri SP, Punyamurthula N, Bhagav P, Majumdar S

Theblood-ocular barriers

Author(s): Cunha-Vaz J

Drug delivery to the retina: challenges and opportunities

Author(s): Duvvuri S,Majumdar S, Mitra AK

Ocularpreparations: the formulation approach

Author(s): Kaur IP, Kanwar M

Evaluation of topical hesperetin matrix filmfor back-of-the-eye delivery

Author(s): Adelli GR, Hingorani T, PunyamurthulaN, Balguri SP, Majumdar S

Ocular inserts - Advancement in therapy of eye diseases

Author(s): Kumari A, Sharma PK, Garg VK,Garg G

Ocular inserts for topical delivery

Author(s): SaettoneFM, Salminen L

Stability of benzocaine formulated in commercialoral disintegrating tablet platforms

Author(s): Köllmer M, Popescu C, Manda P,Zhou L, Gemeinhart RA

New methods of drug delivery

Author(s): Langer R

Iontophoretic drug delivery for the treatment ofscars

Author(s): Manda P, Angamuthu M, HiremathSR, Raman V, Murthy SN

Polysulfone capillary fiber forintraocular drug delivery: in vitro and in vivo evaluations

Author(s): Rahimy MH, PeymanGA, Chin SY, Golshani R, Aras C, et al.

Delivery of cefotaxime to the brain viaintranasal administration

Author(s): Manda P, Hargett JK, Kiran Vaka SR,Repka MA, Narasimha Murthy S

Biodegradable Intrascleral Implant for SustainedIntraocular Delivery of Betamethasone Phosphate

Author(s): Okabe J, Kimura H, Kunou N, OkabeK, Kato A, et al.

Delivery of ziconotide to cerebrospinalfluid via intranasal pathway for the treatment of chronic pain

Author(s): Manda P, Kushwaha AS, Kundu S,Shivakumar H, Jo SB, et al.

Episcleral implants for topotecandelivery to the posterior segment of the eye

Author(s): Carcaboso AM, Chiappetta DA,Opezzo JA, Höcht C, Fandiño AC, et al.