Author(s): Kallweit U, Aritake K, Bassetti CL, Blumenthal S, Hayaishi O, et al.
Background:Histamineisanubiquitousinflammatorymediatorofnumerousphysiologicalprocesses.Histamineanditsreceptorshavebeenimplicatedinmultiplesclerosis(MS)diseasepathogenesis.Weprospectivelyenrolled36MSpatientsand19ageandgender-matchedhealthyvolunteersforcerebrospinalfluid(CSF)histamineanalysis.
Findings:CSFHISTAMINELEVELSINMSPATIENTSAMPLESWERESIGNIFICANTLYHIGHER(MEDIAN:35.6pg/ml)thanincontrols(median:5.5pg/ml;Beta=0.525,p<0.001).Inaddition,histamineincreasedwithage(Pearson'scorrelation,p<0.003).
Conclusions:Histaminemaybeanimportantfactorforboththeinitiationandmaintenanceofchronicinflammatorydiseasesofthecentralnervoussystem.OurobservationencouragesadeeperinvestigationoftheroleofhistamineinMS.
Referred From: https://pubmed.ncbi.nlm.nih.gov/23659456/
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