Recommended Conferences

Clinical Microbiology and Infectious Diseases

Miami, USA

Fungal Infections and Treatments

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

Association between genetic risk score and periodontitis onset and progression: a pilot study

Author(s): Ricci M, Garoia F, Tabarroni C, Marchisio O, Barone A, et al.

Abstract

Aim

Recent research has focused attention on the single nucleotide polymorphisms (SNPs) involved in the host response in periodontitis. However, so as to combine the relatively small effects of individual genes the use of multi locus genetic risk (GRS) has been proposed. This study aims to evaluate whether the genetic risk score may predict periodontitis onset and progression.

Materials and methods

Fifty patients were divided into various groups according to periodontal status. Total DNA was isolated from epithelial oral cells by a masked operator and the selected SNPs were analysed. A GRS was calculated using an additive model.

Results

We found a strong association only between TNF rs1800629 and diffused forms of periodontitis. Data show that GRS is able to discriminate diffused forms of periodontitis from localized ones. Finally, a progressive increase of the GRS is evident in advanced periodontitis in comparison with early forms.

Discussion

In recent years, research on genetic polymorphism has had limited success in predicting the susceptibility to periodontal disease. However, our results indicate that the use of the genetic risk score could be promising. Further studies are necessary to include data from multiple genes so as to confirm our result.

Similar Articles

Molecular aspects of skin ageing

Author(s): Naylor EC, Watson RE, Sherratt MJ

Genotype-activity relationship for Mn-superoxide dismutase,glutathione peroxidase 1 and catalase in humans

Author(s): Bastaki M, Huen K, Manzanillo P, Chande N, Chen C, et al.

Association between a literature-based genetic risk score and cardiovascular events in women

Author(s): Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, et al.

Cosmeceutical peptides

Author(s): Lupo MP, Cole AL

Thrombospondins

Author(s): Josephine C. Adams and Jack Lawler

Improved weight management using genetic information to personalize a calorie controlled diet

Author(s): Arkadianos I, Valdes AM, Marinos E, Florou A, Gill RD, et al.

Association between a literature-based genetic risk score and cardiovascular events in women

Author(s): Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, et al.