Author(s): Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al.
The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency.Participants:
The Task Force was composed of a Chair, six additional experts, and a methodologist. The Task Force received no corporate funding or remuneration.Consensus Process:
Consensus was guided by systematic reviews of evidence and discussions during several conference calls and e-mail communications. The draft prepared by the Task Force was reviewed successively by The Endocrine Society's Clinical Guidelines Subcommittee, Clinical Affairs Core Committee, and cosponsoring associations, and it was posted on The Endocrine Society web site for member review. At each stage of review, the Task Force received written comments and incorporated needed changes.Conclusions:
Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at suggested daily intake and tolerable upper limit levels, depending on age and clinical circumstances. The Task Force also suggested the measurement of serum 25-hydroxyvitamin D level by a reliable assay as the initial diagnostic test in patients at risk for deficiency. Treatment with either vitamin D2 or vitamin D3 was recommended for deficient patients. At the present time, there is not sufficient evidence to recommend screening individuals who are not at risk for deficiency or to prescribe vitamin D to attain the noncalcemic benefit for cardiovascular protection.
Author(s): Mora JR, Iwata M, von Andrian UH
Author(s): Dusso A, Brown A, Slatopolsky E
Author(s): Lemire JM, Adams JS, Sakai R, Jordan SC
Author(s): Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, et al.
Author(s): Devaraj S, Yun JM, Duncan-Staley CR, Jialal I
Author(s): Orgaz-Molina J, Buendía-Eisman A, Arrabal-Polo MA, Ruiz JC
Author(s): Gisondi P, Rossini M, Di Cesare A, Idolazzi L, Farina S, et al.
Author(s): Wilson PB
Author(s): Clemens TL, Garrett KP, Zhou XY, Pike JW, Haussler MR, et al.
Author(s): Adorini L, Penna J
Author(s): Plajo CF, Lopez-Benitez JM, Miller LC
Author(s): Mostafa WZ, Hegazy RA
Author(s): Lesiak A, Narbutt J, Pawlaczyk M, Sysa-Jedrzejowska A, Krzyścin J
Author(s): Cicarma E, Mork C, Porojnicu AC, Juzeniene A, Tam TT, et al.
Author(s): Ryan C, Moran B, McKenna MJ, Murray BF, Brady J, et al.
Author(s): Ala-houhala MJ, Karppinen TT, Vahavihu K, Kautiainen H, Dombrowski Y, et al.
Author(s): Osmancevic A, Landin-Wilhelmsen K, Larko O, Krogstad AL
Author(s): Zuchi MF, Azevedo Pde O, Tanaka AA, Schmitt JV, Martins LE
Author(s): Maleki M, Nahidi Y, Azizahari S, Meibodi NT, Hadianfar A
Author(s): Park BS, Park JS, Lee DY, Youn JI, Kim IG
Author(s): Valdivielso JM, Fernandez E