Recommended Conferences

Fungal Infections and Treatments

Miami, USA

Clinical Microbiology and Infectious Diseases

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments

Author(s): Naval J, Alonso T, Herranz M

Abstract

Introduction: Skin changes are among the most visible signs of aging. Skin properties such as hydration, elasticity, and antioxidant capacity play a key role in the skin aging process. Skin aging is a complex process influenced by heritable and environmental factors. Recent studies on twins have revealed that up to 60% of the skin aging variation between individuals can be attributed to genetic factors, while the remaining 40% is due to non-genetic factors. Recent advances in genomics and bioinformatics approaches have led to the association of certain single nucleotide polymorphisms (SNPs) to skin properties. Our aim was to classify individuals based on an ensemble of multiple polymorphisms associated with certain properties of the skin for providing personalized skin care and anti-aging therapies.
Methods and results: We identified the key proteins and SNPs associated with certain properties of the skin that contribute to skin aging. We selected a set of 13 SNPs in gene coding for these proteins which are potentially associated with skin aging. Finally, we classified a sample of 120 female volunteers into ten clusters exhibiting different skin properties according to their genotypic signature.
Conclusion: This is the first study that describes the actual frequency of genetic polymorphisms and their distribution in clusters involved in skin aging in a Caucasian population. Individuals can be divided into genetic clusters defined by genotypic variables. These genotypic variables are linked with polymorphisms in one or more genes associated with certain properties of the skin that contribute to a person's perceived age. Therefore, by using this classification, it is possible to characterize human skin care and anti-aging needs on the basis of an individual's genetic signature, thus opening the door to personalized treatments addressed at specific populations. This is part of an ongoing effort towards personalized anti-aging therapies combining genetic signatures with environmental and life style evaluations.

Similar Articles

Molecular aspects of skin ageing

Author(s): Naylor EC, Watson RE, Sherratt MJ

Genotype-activity relationship for Mn-superoxide dismutase,glutathione peroxidase 1 and catalase in humans

Author(s): Bastaki M, Huen K, Manzanillo P, Chande N, Chen C, et al.

Association between a literature-based genetic risk score and cardiovascular events in women

Author(s): Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, et al.

Cosmeceutical peptides

Author(s): Lupo MP, Cole AL

Thrombospondins

Author(s): Josephine C. Adams and Jack Lawler

Improved weight management using genetic information to personalize a calorie controlled diet

Author(s): Arkadianos I, Valdes AM, Marinos E, Florou A, Gill RD, et al.

Association between a literature-based genetic risk score and cardiovascular events in women

Author(s): Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, et al.

Association between genetic risk score and periodontitis onset and progression: a pilot study

Author(s): Ricci M, Garoia F, Tabarroni C, Marchisio O, Barone A, et al.