Recommended Conferences

Fungal Infections and Treatments

Miami, USA

Clinical Microbiology and Infectious Diseases

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis:interaction with their plasma levels

Author(s): Buchs N, di Giovine FS, Silvestri T, Vannier E, Duff GW, et al.

Abstract

The balance between interleukin-1 (IL-1) and its competitive antagonist IL-1 receptor antagonist (IL-1Ra) may contribute to the pathogenesis of rheumatoid arthritis (RA). We analysed the frequency of different alleles in the IL-1B gene (at −511 and at +3954) as well as in the IL-1Ra gene (at +2018) in an association study involving 297 RA patients and 112 healthy controls from the same geographic area. We tested associations with RA susceptibility or severity, and with circulating levels of IL-1Ra and IL-1β. Carriage of the rare IL-1B (+3954) allele 2 was increased in destructive arthritis (DRA) as compared to non-destructive arthritis (NDRA) (OR 1.7, 95% CI 1.1–2.8, 49.0% vs 35.9%) and controls (OR 1.7, 95% CI 1.1–2.8, 35.8%). Patients carrying this allele had a more destructive (Larsen wrist radiological index: mean ± s.e.m., 2.1 ± 0.2 vs 1.6 ± 0.1, P = 0.005; Steinbrocker functional index: 2.4 ± 0.1 vs 1.9 ± 0.1, P = 0.002) and active disease (Ritchie articular index: 8.1 ± 0.8 vs 5.3 ± 0.6, P = 0.002; erythrocyte sedimentation rate (ESR): 36.6 ± 2.9 mm/h vs 25.3 ± 1.8 mm/h, P = 0.002). This contribution was independent from that of HLA DR4/DR1 to severity. IL-1Ra plasma levels adjusted to ESR values were significantly lower in IL-1B2 (+3954) positive than negative RA patients (1.0 ± 0.1 vs 1.2 ± 0.1 ng/ml, P = 0.01). This IL-1B (+3954) gene polymorphism may be an important marker for the severity of joint destruction in RA and is associated with an imbalance in IL-1Ra production. As this genetic association was independent and additive to the risk of HLA DR4/DR1 status, it could be a useful addition to HLA-DR4/1 as a genetic prognostic marker early in the course of the disease.

Similar Articles

Molecular aspects of skin ageing

Author(s): Naylor EC, Watson RE, Sherratt MJ

Genotype-activity relationship for Mn-superoxide dismutase,glutathione peroxidase 1 and catalase in humans

Author(s): Bastaki M, Huen K, Manzanillo P, Chande N, Chen C, et al.

Association between a literature-based genetic risk score and cardiovascular events in women

Author(s): Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, et al.

Cosmeceutical peptides

Author(s): Lupo MP, Cole AL

Thrombospondins

Author(s): Josephine C. Adams and Jack Lawler

Improved weight management using genetic information to personalize a calorie controlled diet

Author(s): Arkadianos I, Valdes AM, Marinos E, Florou A, Gill RD, et al.

Association between a literature-based genetic risk score and cardiovascular events in women

Author(s): Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, et al.

Association between genetic risk score and periodontitis onset and progression: a pilot study

Author(s): Ricci M, Garoia F, Tabarroni C, Marchisio O, Barone A, et al.