Recommended Conferences

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

Nonsunscreen photoprotection: antioxidants add value to a sunscreen

Author(s): Matsui MS, Hsia A, Miller JD, Hanneman K, Scull H, et al.

Abstract

The association between ultraviolet radiation (UVR) exposure and both skin cancer and photo-aging is well documented. In addition to the conventional organic-chemical and physical-mineral type sunscreens, other non-sunscreen protective strategies have been developed. These include topically applied botanical extracts and other antioxidants as well as topical DNA repair enzymes. Standard terms of photoprotection such as sun protection factor (SPF) do not accurately reflect the photoprotection benefits of these materials. For example, in spite of minimal SPF, tea extract containing polyphenols such as (-)-epigallocatechin-3-gallate (EGCG) has been shown to protect against UV-induced DNA damage and immune suppression, in part through its ability to reduce oxidative stress and inhibit NF-kB. The addition of botanical antioxidants and vitamins C and E to a broad-spectrum sunscreen may further decrease UV-induced damage compared with sunscreen alone. These agents have been shown to enhance protection against UV-induced epidermal thickening, overexpression of MMP-1and MMP-9, and depletion of CD1a+ Langerhans cells. Non-sunscreen materials such as botanical extracts, antioxidants, and DNA repair enzymes can contribute value when applied topically to human skin in vivo.

Similar Articles

The role of antioxidants in skin cancer prevention and treatment

Author(s): Godic A, Poljšak B, Adamic M, Dahmane R

Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fiber in vitro tumors

Author(s): Casciari JJ, Riordan NH, Schmidt TL, Meng XL, Jackson JA, et al.

Ascorbic acid: Chemistry, biology and the treatment of cancer

Author(s): Juan Du, Joseph J. Cullena, Garry R. Buettner

Vitamin C promotes wound healing through novel pleiotropic mechanisms

Author(s): Mohammed BM, Fisher BJ, Kraskauskas D, War S, Wayne JS, et al.

Vitamin C promotes wound healing through novel pleiotropic mechanisms

Author(s): Mohammed B, Fisher BJ, Kraskauskas D, War S, Wayne JS, et al.

Vitamin C for DNA damage prevention

Author(s): Sram RJ, Binkova B, Rossner P

Effects of business-as-usual anthropogenic emissions on air quality

Author(s): Pozzer A, Zimmermann P, Doering U, Van Aardenne J, Tost H, et al.

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation

Author(s): Bruno RS, Leonard SW, Atkinson J, Montine TJ, Ramakrishnan R, et al.

Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin

Author(s): Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, et al.

Vitamin C and Immune Function

Author(s): Anitra CC, Silvia M

Monocyte locomotion in anergic chronic brucellosis patients: The in vivo effect of ascorbic acid

Author(s): Boura P, Tsapas G, Papadopoulou A, Magoula I, Kountouras G