Recommended Conferences

Clinical Microbiology and Infectious Diseases

Miami, USA

Fungal Infections and Treatments

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

Systems approaches to polypharmacology and drug discovery

Author(s): Boran ADW, Iyengar R

Abstract

Systems biology uses experimental and computational approaches to characterize large sample populations systematically, process large datasets, examine and analyze regulatory networks, and model reactions to determine how components are joined to form functional systems. Systems biology technologies, data and knowledge are particularly useful in understanding disease processes and drug actions. An important area of integration between systems biology and drug discovery is the concept of polypharmacology: the treatment of diseases by modulating more than one target. Polypharmacology for complex diseases is likely to involve multiple drugs acting on distinct targets that are part of a network regulating physiological responses. This review discusses the current state of the systems-level understanding of diseases and both the therapeutic and adverse mechanisms of drug actions. Drug-target networks can be used to identify multiple targets and to determine suitable combinations of drug targets or drugs. Thus, the discovery of new drug therapies for complex diseases may be greatly aided by systems biology.

Similar Articles

The burden of skin diseases

Author(s): Bickers DR, Lim HW, Margolis D, Weinstock MA, Goodman C, et al.

The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions

Author(s): Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP et al.

Economic Burden of Psoriasis in the United States

Author(s): Brezinski EA, Dhillon JS, Armstrong AW

Maintaining skin integrity in the aged: A systematic review

Author(s): Kottner J, Lichterfeld A, Blume-Peytavi U

Adalimumab regulates intracellular TNFa production in patients with rheumatoid arthritis

Author(s): Zamora-Atenza C, Diaz-Torne C, Geli C, Diaz-Lopez C, Ortiz MA, et al.

Nuclear receptors and lipid physiology: opening the X-files

Author(s): Chawla A, Repa R, Evans M, Mangelsord DJ

The pleiotropic actions of vitamin D

Author(s): Lin R, White JH

Vitamin D and the anti-viral state

Author(s): Jeremy A. Beard A, Striker A

Therapeutic implications of the TLR and VDR partnership

Author(s): Liu PT, Krutzik SR, Modlin RL

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D dependent mechanism

Author(s): Robert SJA, Dorschner, Coda AB, Büchau AS, Liu PT, et al.

2016

Author(s): Arantes EL, Dragano N, Ramalho A, Vitorino D, de-Souza GF, et al

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Author(s): Da Young Oh, Walenta E, Akiyama TE, Lagakos WS, Lackey D, et al.

Vitamin D receptor is essential for normal keratinocyte stem cell function

Author(s): Cianferotti L, Cox M, Skorija K, Demay MB

UV photoprotection by combination topical antioxidants vitamin C and vitamin E

Author(s): Lin JY, Selim MA, Shea CR, Grichnik JM, Omar MM, et al.

CAM use in dermatology

Author(s): Barbosa NS, Kalaaji AN

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

Author(s): Crisan D, Roman I, Crisan M, Scharffetter-Kochanek K, Badea R

MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search

Author(s): Noa Rappaport, Twik M, Plaschkes I, Nudel R, Iny Stein T, Levitt J, et al.

The burden of skin diseases

Author(s): Bickers DR, Lim HW, Margolis D, Weinstock MA, Goodman C, et al.

The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions

Author(s): Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP et al.

Economic Burden of Psoriasis in the United States

Author(s): Brezinski EA, Dhillon JS, Armstrong AW

Maintaining skin integrity in the aged: A systematic review

Author(s): Kottner J, Lichterfeld A, Blume-Peytavi U

Adalimumab regulates intracellular TNFa production in patients with rheumatoid arthritis

Author(s): Zamora-Atenza C, Diaz-Torne C, Geli C, Diaz-Lopez C, Ortiz MA, et al.

Nuclear receptors and lipid physiology: opening the X-files

Author(s): Chawla A, Repa R, Evans M, Mangelsord DJ

The pleiotropic actions of vitamin D

Author(s): Lin R, White JH

Vitamin D and the anti-viral state

Author(s): Jeremy A. Beard A, Striker A

Therapeutic implications of the TLR and VDR partnership

Author(s): Liu PT, Krutzik SR, Modlin RL

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D dependent mechanism

Author(s): Robert SJA, Dorschner, Coda AB, Büchau AS, Liu PT, et al.

2016

Author(s): Arantes EL, Dragano N, Ramalho A, Vitorino D, de-Souza GF, et al

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Author(s): Da Young Oh, Walenta E, Akiyama TE, Lagakos WS, Lackey D, et al.

Vitamin D receptor is essential for normal keratinocyte stem cell function

Author(s): Cianferotti L, Cox M, Skorija K, Demay MB

UV photoprotection by combination topical antioxidants vitamin C and vitamin E

Author(s): Lin JY, Selim MA, Shea CR, Grichnik JM, Omar MM, et al.

CAM use in dermatology

Author(s): Barbosa NS, Kalaaji AN

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

Author(s): Crisan D, Roman I, Crisan M, Scharffetter-Kochanek K, Badea R