Recommended Conferences

Clinical Microbiology and Infectious Diseases

Miami, USA

Fungal Infections and Treatments

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

The role of antioxidants in skin cancer prevention and treatment

Author(s): Godic A, Poljšak B, Adamic M, Dahmane R

Abstract

Skin cells are constantly exposed to reactive oxygen species (ROS) and oxidative stress from exogenous and endogenous sources. UV radiation is the most important environmental factor in the development of skin cancer and skin aging. The primary products caused by UV exposure are generally direct DNA oxidation or generation of free radicals which form and decompose extremely quickly but can produce effects that can last for hours, days, or even years. UV-induced generation of ROS in the skin develops oxidative stress when their formation exceeds the antioxidant defense ability. The reduction of oxidative stress can be achieved on two levels: by lowering exposure to UVR and/or by increasing levels of antioxidant defense in order to scavenge ROS. The only endogenous protection of our skin is melanin and enzymatic antioxidants. Melanin, the pigment deposited by melanocytes, is the first line of defense against DNA damage at the surface of the skin, but it cannot totally prevent skin damage. A second category of defense is repair processes, which remove the damaged biomolecules before they can accumulate and before their presence results in altered cell metabolism. Additional UV protection includes avoidance of sun exposure, usage of sunscreens, protective clothes, and antioxidant supplements.

Similar Articles

Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fiber in vitro tumors

Author(s): Casciari JJ, Riordan NH, Schmidt TL, Meng XL, Jackson JA, et al.

Ascorbic acid: Chemistry, biology and the treatment of cancer

Author(s): Juan Du, Joseph J. Cullena, Garry R. Buettner

Vitamin C promotes wound healing through novel pleiotropic mechanisms

Author(s): Mohammed BM, Fisher BJ, Kraskauskas D, War S, Wayne JS, et al.

Vitamin C promotes wound healing through novel pleiotropic mechanisms

Author(s): Mohammed B, Fisher BJ, Kraskauskas D, War S, Wayne JS, et al.

Vitamin C for DNA damage prevention

Author(s): Sram RJ, Binkova B, Rossner P

Effects of business-as-usual anthropogenic emissions on air quality

Author(s): Pozzer A, Zimmermann P, Doering U, Van Aardenne J, Tost H, et al.

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation

Author(s): Bruno RS, Leonard SW, Atkinson J, Montine TJ, Ramakrishnan R, et al.

Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin

Author(s): Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, et al.

Vitamin C and Immune Function

Author(s): Anitra CC, Silvia M

Monocyte locomotion in anergic chronic brucellosis patients: The in vivo effect of ascorbic acid

Author(s): Boura P, Tsapas G, Papadopoulou A, Magoula I, Kountouras G

Nonsunscreen photoprotection: antioxidants add value to a sunscreen

Author(s): Matsui MS, Hsia A, Miller JD, Hanneman K, Scull H, et al.