Recommended Conferences

Clinical Microbiology and Infectious Diseases

Miami, USA

Fungal Infections and Treatments

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

Author(s): Kawai T, Akira S

Abstract

The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, it is now clear that the interaction between TLRs and recently identified cytosolic innate immune sensors is crucial for mounting effective immune responses. Here we describe the recent advances that have been made by research into the role of TLR biology in host defense and disease.

Similar Articles

The prevalence of acne in adults 20 years and older

Author(s): Collier CN, Harper JC, Cafardi JA, Cantrell WC, Wang W, et al.

A new phylogenetic group of Propionibacterium acnes

Author(s): McDowell A, Perry AL, Lambert PA, Patrick S

Effect of benzoyl peroxide on lipogenesis in sebaceous glands using an animal model

Author(s): Burkhart CG, Butcher C, Burkhart CN, Lehmann PF

Responses to amyloids of microbial and host origin are mediated through toll-like receptor 2

Author(s): Tukel C, Wilson RP, Nishimori JH, Pezeshki M, Chromy BA, et al.

Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2

Author(s): Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, et al.

Acne, quorum sensing and danger

Author(s): Lwin SM, Kimber I, Mcfadden JP

Penicillin: the new/old wonder drug

Author(s): Allen HB, Hossain C, Abidi N, Larijani M, Joshi SG

Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms

Author(s): Brackman G, Forier K, Al quntar AA, De Canck E, Enk CD, et al.