Author(s): Kawai T, Akira S
The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, it is now clear that the interaction between TLRs and recently identified cytosolic innate immune sensors is crucial for mounting effective immune responses. Here we describe the recent advances that have been made by research into the role of TLR biology in host defense and disease.
Referred From: http://www.nature.com/articles/ni.1863
Author(s): Collier CN, Harper JC, Cafardi JA, Cantrell WC, Wang W, et al.
Author(s): McDowell A, Perry AL, Lambert PA, Patrick S
Author(s): Coates A, Hu Y, Bax R, Page C
Author(s): Holmberg A, Lood R, Mörgelin M
Author(s): Tyner H, Patel R
Author(s): Coenye T, Peeters E, Nelis HJ
Author(s): Burkhart CG, Burkhart CN
Author(s): Bruggeman H, Henne A, Hoster F
Author(s): Jahns AC, Lundskog B, Ganceviciene R
Author(s): Jahns AC, Alexeyev OA
Author(s): Burkhart CG, Butcher C, Burkhart CN, Lehmann PF
Author(s): Nagy I, Pivarcsi A, Koreck A, Széll M, Urbán E, et al.
Author(s): Tukel C, Wilson RP, Nishimori JH, Pezeshki M, Chromy BA, et al.
Author(s): Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, et al.
Author(s): Lwin SM, Kimber I, Mcfadden JP
Author(s): Sivasankar C, Maruthupandiyan S, Balamurugan K, James PB, Krishnan V, et al.
Author(s): Coenye T, Brackman G, Rigole P
Author(s): Feuillolay C, Pecastaings S, Le gac C, Fiorini-Puybaret C, Luc J, et al.
Author(s): Allen HB, Hossain C, Abidi N, Larijani M, Joshi SG
Author(s): Brackman G, Forier K, Al quntar AA, De Canck E, Enk CD, et al.