Recommended Conferences

Fungal Infections and Treatments

Miami, USA

Clinical Microbiology and Infectious Diseases

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects

Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women’s Health Study

Author(s): Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, et al.


Objective.Vitamin D is a potent regulator ofcalcium homeostasis and may have immunomodulatoryeffects. The influence of vitamin D on human auto-immune disease has not been well defined. The purposeof this study was to evaluate the association of dietaryand supplemental vitamin D intake with rheumatoidarthritis (RA) incidence.Methods.We analyzed data from a prospectivecohort study of 29,368 women of ages 55–69 yearswithout a history of RA at study baseline in 1986. Dietwas ascertained using a self-administered, 127-itemvalidated food frequency questionnaire that includedsupplemental vitamin D use. Risk ratios (RRs) and 95%confidence intervals (95% CIs) were estimated usingCox proportional hazards regression, adjusting for po-tential confounders.Results.Through 11 years of followup, 152 casesof RA were validated against medical records. Greaterintake (highest versus lowest tertile) of vitamin D wasinversely associated with risk of RA (RR 0.67, 95% CI0.44–1.00,Pfor trend0.05). Inverse associations wereapparent for both dietary (RR 0.72, 95% CI 0.46–1.14,Pfor trend0.16) and supplemental (RR 0.66, 95% CI0.43–1.00,Pfor trend0.03) vitamin D. No individualfood item high in vitamin D content and/or calcium wasstrongly associated with RA risk, but a composite mea-sure of milk products was suggestive of an inverseassociation with risk of RA (RR 0.66, 95% CI 0.42–1.01,Pfor trend0.06).Conclusion.Greater intake of vitamin D may beassociated with a lower risk of RA in older women,although this finding is hypothesis generating.

Similar Articles

Vitamin D

Author(s): Dusso A, Brown A, Slatopolsky E

Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study

Author(s): Orgaz-Molina J, Buendía-Eisman A, Arrabal-Polo MA, Ruiz JC

Vitamin D status in patients with chronic plaque psoriasis

Author(s): Gisondi P, Rossini M, Di Cesare A, Idolazzi L, Farina S, et al.

Evaluation, treatment and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline

Author(s): Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al.

Immunocytochemical localization of the 1,25-dihydroxyvitamin-D3 receptor in target cells

Author(s): Clemens TL, Garrett KP, Zhou XY, Pike JW, Haussler MR, et al.

Vitamin D and autoimmune rheumatologic disorders

Author(s): Plajo CF, Lopez-Benitez JM, Miller LC

Influence of narrowband UVB phototherapy on vitamin D and folate status

Author(s): Cicarma E, Mork C, Porojnicu AC, Juzeniene A, Tam TT, et al.

The effect of narrowband UV-B treatment for psoriasis on vitamin D status during wintertime in Ireland

Author(s): Ryan C, Moran B, McKenna MJ, Murray BF, Brady J, et al.

Narrowband ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation

Author(s): Ala-houhala MJ, Karppinen TT, Vahavihu K, Kautiainen H, Dombrowski Y, et al.

Vitamin D status in psoriasis patients during different treatments with phototherapy

Author(s): Osmancevic A, Landin-Wilhelmsen K, Larko O, Krogstad AL

Serum levels of 25-hydroxy vitamin D in psoriatic patients

Author(s): Zuchi MF, Azevedo Pde O, Tanaka AA, Schmitt JV, Martins LE

Serum 25- OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects

Author(s): Maleki M, Nahidi Y, Azizahari S, Meibodi NT, Hadianfar A

Vitamin D receptor polymorphism is associated with psoriasis

Author(s): Park BS, Park JS, Lee DY, Youn JI, Kim IG

Vitamin D receptor polymorphisms and diseases

Author(s): Valdivielso JM, Fernandez E