Recommended Conferences

Fungal Infections and Treatments

Miami, USA

Clinical Microbiology and Infectious Diseases

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

Vitamin D receptor is essential for normal keratinocyte stem cell function

Author(s): Cianferotti L, Cox M, Skorija K, Demay MB

Abstract

The major physiological role of the vitamin D receptor (VDR) is the maintenance of mineral ion homeostasis. Mutation of the VDR, in humans and mice, results in alopecia. Unlike the effects of the VDR on mineral ion homeostasis, the actions of the VDR that prevent alopecia are ligand-independent. Although absence of the VDR does not prevent the development of a keratinocyte stem cell niche in the bulge region of the hair follicle, it results in an inability of these stem cells to regenerate the lower portion of the hair follicle in vivo and impairs keratinocyte stem cell colony formation in vitro. VDR ablation is associated with a gradual decrease in keratinocyte stem cells, accompanied by an increase in sebaceous activity, a phenotype analogous to that seen with impaired canonical Wnt signaling. Transient gene expression assays demonstrate that the cooperative transcriptional effects of β-catenin and Lef1 are abolished in keratinocytes isolated from VDR-null mice, revealing a role for the unliganded VDR in canonical Wnt signaling. Thus, absence of the VDR impairs canonical Wnt signaling in keratinocytes and leads to the development of alopecia due to a defect in keratinocyte stem cells.

Similar Articles

The burden of skin diseases

Author(s): Bickers DR, Lim HW, Margolis D, Weinstock MA, Goodman C, et al.

The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions

Author(s): Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP et al.

Economic Burden of Psoriasis in the United States

Author(s): Brezinski EA, Dhillon JS, Armstrong AW

Maintaining skin integrity in the aged: A systematic review

Author(s): Kottner J, Lichterfeld A, Blume-Peytavi U

Adalimumab regulates intracellular TNFa production in patients with rheumatoid arthritis

Author(s): Zamora-Atenza C, Diaz-Torne C, Geli C, Diaz-Lopez C, Ortiz MA, et al.

Nuclear receptors and lipid physiology: opening the X-files

Author(s): Chawla A, Repa R, Evans M, Mangelsord DJ

The pleiotropic actions of vitamin D

Author(s): Lin R, White JH

Vitamin D and the anti-viral state

Author(s): Jeremy A. Beard A, Striker A

Therapeutic implications of the TLR and VDR partnership

Author(s): Liu PT, Krutzik SR, Modlin RL

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D dependent mechanism

Author(s): Robert SJA, Dorschner, Coda AB, Büchau AS, Liu PT, et al.

2016

Author(s): Arantes EL, Dragano N, Ramalho A, Vitorino D, de-Souza GF, et al

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Author(s): Da Young Oh, Walenta E, Akiyama TE, Lagakos WS, Lackey D, et al.

UV photoprotection by combination topical antioxidants vitamin C and vitamin E

Author(s): Lin JY, Selim MA, Shea CR, Grichnik JM, Omar MM, et al.

CAM use in dermatology

Author(s): Barbosa NS, Kalaaji AN

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

Author(s): Crisan D, Roman I, Crisan M, Scharffetter-Kochanek K, Badea R

MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search

Author(s): Noa Rappaport, Twik M, Plaschkes I, Nudel R, Iny Stein T, Levitt J, et al.

The burden of skin diseases

Author(s): Bickers DR, Lim HW, Margolis D, Weinstock MA, Goodman C, et al.

The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions

Author(s): Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP et al.

Economic Burden of Psoriasis in the United States

Author(s): Brezinski EA, Dhillon JS, Armstrong AW

Maintaining skin integrity in the aged: A systematic review

Author(s): Kottner J, Lichterfeld A, Blume-Peytavi U

Adalimumab regulates intracellular TNFa production in patients with rheumatoid arthritis

Author(s): Zamora-Atenza C, Diaz-Torne C, Geli C, Diaz-Lopez C, Ortiz MA, et al.

Nuclear receptors and lipid physiology: opening the X-files

Author(s): Chawla A, Repa R, Evans M, Mangelsord DJ

The pleiotropic actions of vitamin D

Author(s): Lin R, White JH

Vitamin D and the anti-viral state

Author(s): Jeremy A. Beard A, Striker A

Therapeutic implications of the TLR and VDR partnership

Author(s): Liu PT, Krutzik SR, Modlin RL

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D dependent mechanism

Author(s): Robert SJA, Dorschner, Coda AB, Büchau AS, Liu PT, et al.

2016

Author(s): Arantes EL, Dragano N, Ramalho A, Vitorino D, de-Souza GF, et al

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Author(s): Da Young Oh, Walenta E, Akiyama TE, Lagakos WS, Lackey D, et al.

Vitamin D receptor is essential for normal keratinocyte stem cell function

Author(s): Cianferotti L, Cox M, Skorija K, Demay MB

UV photoprotection by combination topical antioxidants vitamin C and vitamin E

Author(s): Lin JY, Selim MA, Shea CR, Grichnik JM, Omar MM, et al.

CAM use in dermatology

Author(s): Barbosa NS, Kalaaji AN

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

Author(s): Crisan D, Roman I, Crisan M, Scharffetter-Kochanek K, Badea R