Recommended Conferences

Fungal Infections and Treatments

Miami, USA

Clinical Microbiology and Infectious Diseases

Miami, USA

Cancer-Treatment and Therapeutics

New York, USA
Related Subjects
 

Vitamin D status in patients with chronic plaque psoriasis

Author(s): Gisondi P, Rossini M, Di Cesare A, Idolazzi L, Farina S, et al.

Abstract

Background Vitamin D could have important immunomodulatory effects in psoriasis.

Objectives To measure 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients with psoriasis and the associations with some relevant clinical features.

Methods A cross-sectional study was conducted over 1 year including 145 patients with chronic plaque psoriasis, 112 patients with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured in a centralized laboratory. Demography, comorbidities, disease severity and exposure time to sunlight (which was derived by questionnaire) were collected.

Results The prevalence of vitamin D deficiency [25(OH)D levels < 20 ng mL−1] in patients with psoriasis was 57·8% vs. 37·5% in patients with RA and 29·7% in healthy controls (P < 0·001). In winter, the prevalence of vitamin D deficiency rose to 80·9% in patients with psoriasis, to 41·3% in those with RA and to 30·3% in healthy controls (P < 0·001). Patients with psoriasis or psoriatic arthritis did not differ in 25(OH)D serum levels nor in the prevalence of vitamin D deficiency. In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling. A limitation is that the study design does not allow a causal or temporal relationship between vitamin D deficiency and psoriasis to be established.

Conclusions Vitamin D deficiency may be common in patients with psoriasis, especially in winter.

Similar Articles

Vitamin D

Author(s): Dusso A, Brown A, Slatopolsky E

Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women’s Health Study

Author(s): Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, et al.

Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: a case-control study

Author(s): Orgaz-Molina J, Buendía-Eisman A, Arrabal-Polo MA, Ruiz JC

Evaluation, treatment and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline

Author(s): Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al.

Immunocytochemical localization of the 1,25-dihydroxyvitamin-D3 receptor in target cells

Author(s): Clemens TL, Garrett KP, Zhou XY, Pike JW, Haussler MR, et al.

Vitamin D and autoimmune rheumatologic disorders

Author(s): Plajo CF, Lopez-Benitez JM, Miller LC

Influence of narrowband UVB phototherapy on vitamin D and folate status

Author(s): Cicarma E, Mork C, Porojnicu AC, Juzeniene A, Tam TT, et al.

The effect of narrowband UV-B treatment for psoriasis on vitamin D status during wintertime in Ireland

Author(s): Ryan C, Moran B, McKenna MJ, Murray BF, Brady J, et al.

Narrowband ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation

Author(s): Ala-houhala MJ, Karppinen TT, Vahavihu K, Kautiainen H, Dombrowski Y, et al.

Vitamin D status in psoriasis patients during different treatments with phototherapy

Author(s): Osmancevic A, Landin-Wilhelmsen K, Larko O, Krogstad AL

Serum levels of 25-hydroxy vitamin D in psoriatic patients

Author(s): Zuchi MF, Azevedo Pde O, Tanaka AA, Schmitt JV, Martins LE

Serum 25- OH Vitamin D Level in Psoriatic Patients and Comparison With Control Subjects

Author(s): Maleki M, Nahidi Y, Azizahari S, Meibodi NT, Hadianfar A

Vitamin D receptor polymorphism is associated with psoriasis

Author(s): Park BS, Park JS, Lee DY, Youn JI, Kim IG

Vitamin D receptor polymorphisms and diseases

Author(s): Valdivielso JM, Fernandez E