Author(s): Gisondi P, Rossini M, Di Cesare A, Idolazzi L, Farina S, et al.
Background Vitamin D could have important immunomodulatory effects in psoriasis.
Objectives To measure 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and calcium serum levels in patients with psoriasis and the associations with some relevant clinical features.
Methods A cross-sectional study was conducted over 1 year including 145 patients with chronic plaque psoriasis, 112 patients with rheumatoid arthritis (RA) and 141 healthy controls. 25(OH)D, PTH and calcium serum levels were measured in a centralized laboratory. Demography, comorbidities, disease severity and exposure time to sunlight (which was derived by questionnaire) were collected.
Results The prevalence of vitamin D deficiency [25(OH)D levels < 20 ng mL−1] in patients with psoriasis was 57·8% vs. 37·5% in patients with RA and 29·7% in healthy controls (P < 0·001). In winter, the prevalence of vitamin D deficiency rose to 80·9% in patients with psoriasis, to 41·3% in those with RA and to 30·3% in healthy controls (P < 0·001). Patients with psoriasis or psoriatic arthritis did not differ in 25(OH)D serum levels nor in the prevalence of vitamin D deficiency. In the logistic regression analysis, vitamin D deficiency was associated with psoriasis independently of age, sex, body mass index, calcium, PTH levels and season of blood sampling. A limitation is that the study design does not allow a causal or temporal relationship between vitamin D deficiency and psoriasis to be established.
Conclusions Vitamin D deficiency may be common in patients with psoriasis, especially in winter.
Author(s): Mora JR, Iwata M, von Andrian UH
Author(s): Dusso A, Brown A, Slatopolsky E
Author(s): Lemire JM, Adams JS, Sakai R, Jordan SC
Author(s): Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, et al.
Author(s): Devaraj S, Yun JM, Duncan-Staley CR, Jialal I
Author(s): Orgaz-Molina J, Buendía-Eisman A, Arrabal-Polo MA, Ruiz JC
Author(s): Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al.
Author(s): Wilson PB
Author(s): Clemens TL, Garrett KP, Zhou XY, Pike JW, Haussler MR, et al.
Author(s): Adorini L, Penna J
Author(s): Plajo CF, Lopez-Benitez JM, Miller LC
Author(s): Mostafa WZ, Hegazy RA
Author(s): Lesiak A, Narbutt J, Pawlaczyk M, Sysa-Jedrzejowska A, Krzyścin J
Author(s): Cicarma E, Mork C, Porojnicu AC, Juzeniene A, Tam TT, et al.
Author(s): Ryan C, Moran B, McKenna MJ, Murray BF, Brady J, et al.
Author(s): Ala-houhala MJ, Karppinen TT, Vahavihu K, Kautiainen H, Dombrowski Y, et al.
Author(s): Osmancevic A, Landin-Wilhelmsen K, Larko O, Krogstad AL
Author(s): Zuchi MF, Azevedo Pde O, Tanaka AA, Schmitt JV, Martins LE
Author(s): Maleki M, Nahidi Y, Azizahari S, Meibodi NT, Hadianfar A
Author(s): Park BS, Park JS, Lee DY, Youn JI, Kim IG
Author(s): Valdivielso JM, Fernandez E