A bicarbonate-alkaline mineral water protects from ethanol-induced hemorrhagic gastric lesions in mice

Author(s): Nassini R, Andrè E, Gazzieri D, De Siena G, Zanasi A, et al.


Ingestion of elevated amounts of ethanol in humans and rodents induces hemorrhagic gastric lesions, at least in part by increasing oxidative stress. The present study was undertaken in order to evaluate the influence of a bicarbonate-alkaline mineral water (Uliveto on ethanol-induced hemorrhagic gastric lesions in mice. Lesions were evaluated by both macroscopic and microscopic analysis. In a first set of experiments, mice were allowed to drink Uliveto or reference water ad libitum until 3 h prior to intragastric (i.g.) ethanol (23 ml/kg) administration. Neither Uliveto nor reference water did afford any protection. In a second set of experiments, acute exposure to reference water (35 ml/kg, i.g.), given 30 min before ethanol, did not inhibit gastric lesions. However, administration of the same amount of Uliveto caused a remarkable reduction in ethanol-evoked gastric lesions. Ethanol administration increased 4-hydroxy-2-nonenal levels, a byproduct of oxidative stress, in the luminal part of the gastric mucosa. This response was substantially reduced by about 70% by Uliveto, but not by reference water. Reference water, added with the bicarbonate content, present in the Uliveto water, protected against ethanol-induced lesions. Thus, acute pre-exposure to bicarbonate-alkaline mineral water (Uliveto) protects from both oxidative stress and hemorrhagic gastric lesions caused by ethanol. The elevated bicarbonate content of Uliveto likely accounts for the protection against ethanol-induced gastric injury.

Similar Articles

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

Author(s): Wild S, Roglic G, Green A, Sicree R, King H

Oxidative stress, nitric oxide, and diabetes

Author(s): Pitocco D, Zaccardi F, Di Stasio E, Romitelli F, Santini SA, et al.

Oxidative stress, diabetes, and diabetic complications

Author(s): Wei W, Liu Q, Tan Y, Liu L, Li X, et al.

Selenium: biochemical role as a component of glutathione peroxidase

Author(s): Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, et al.

Metal sites of copper-zinc superoxide dismutase

Author(s): Beem KM, Richardson DC, Rajagopalan KV

An iron-based cytosolic catalase and superoxide dismutase mimic complex

Author(s): Horn A Jr, Parrilha GL, Melo KV, Fernandes C, Horner M, et al.

The protective effect of montelukast sodium on carbon tetrachloride induced hepatopathy in rat

Author(s): Cuciureanu M, Caruntu ID, Paduraru O, Stoica B, Jerca L, et al.

Anti-diabetic effect of alkaline-reduced water on OLETF rats

Author(s): Jin D, Ryu SH, Kim HW, Yang EJ, Lim SJ, et al.

Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage

Author(s): Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, et al.

Haemoglobin A1c levels and subsequent cardiovascular disease in persons without diabetes: a meta-analysis of prospective cohorts

Author(s): Santos-Oliveira R, Purdy C, da Silva MP, dos Anjos Carneiro-Leão AM, Machado M, et al.