Author(s): Kershaw EE, Flier JS
Adipose tissue is a complex, essential, and highly active metabolic and endocrine organ. Besides adipocytes, adipose tissue contains connective tissue matrix, nerve tissue, stromovascular cells, and immune cells. Together these components function as an integrated unit. Adipose tissue not only responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine functions. These factors include leptin, other cytokines, adiponectin, complement components, plasminogen activator inhibitor-1, proteins of the renin-angiotensin system, and resistin. Adipose tissue is also a major site for metabolism of sex steroids and glucocorticoids. The important endocrine function of adipose tissue is emphasized by the adverse metabolic consequences of both adipose tissue excess and deficiency. A better understanding of the endocrine function of adipose tissue will likely lead to more rational therapy for these increasingly prevalent disorders. This review presents an overview of the endocrine functions of adipose tissue.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/15181022
Author(s): Arner P
Author(s): Chen MP, Chung FM, Chang DM, Tsai JC, Huang HF, et al.
Author(s): Fantuzzi G
Author(s): Filippatos TD, Randeva HS, Derdemezis CS, Elisaf MS, Mikhailidis DP
Author(s): Adeghate E
Author(s): Alberti KG, Zimmet PZ
Author(s): Laakso M, Pyorala K
Author(s): Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al.
Author(s): Kim MK, Lee JH, Kim H, Park SJ, Kim SH, et al.
Author(s): Derosa G, Maffioli P, Salvadeo SA, Ferrari I, Gravina A, et al.
Author(s): Sakamoto A, Ishizaka Y, Toda E, Nagai R, Koike K, et al.
Author(s): Guagnano MT, Romano M, Falco A, Nutini M, Marinopiccoli M, et al.
Author(s): Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, et al.
Author(s): Araki S, Dobashi K, Kubo K, Kawagoe R, Yamamoto Y, et al.
Author(s): Kim JH, Kim SH, Im JA, Lee DC
Author(s): Pfutzner A, Hanefeld M, Lübben G, Weber MM, Karagiannis E, et al.
Author(s): Kaminska A, Kopczynska E, Bronisz A, Zmudzinska M, Bielinski M, et al.
Author(s): Haider DG, Schindler K, Schaller G, Prager G, Wolzt M, et al.
Author(s): García-Fuentes E, García-Almeida JM, García-Arnés J, García-Serrano S, Rivas-Marín J, et al.
Author(s): Chang YH, Chang DM, Lin KC, Shin SJ, Lee YJ
Author(s): Pagano C, Pilon C, Olivieri M, Mason P, Fabris R, et al.
Author(s): Jian WX, Luo TH, Gu YY, Zhang HL, Zheng S et al.
Author(s): López-Bermejo A, Chico-Julià B, Fernàndez-Balsells M, Recasens M, Esteve E, et al.
Author(s): Sharma AM, Chetty VT
Author(s): Fasshauer M, Paschke R