Author(s): Shinde J, Taldone T, Barletta M, Kunaparaju N, Hu B, et al.
Syzygium cumini seed kernel extracts were evaluated for the inhibition of alpha-glucosidase from mammalian (rat intestine), bacterial (Bacillus stearothermophilus), and yeast (Saccharomyces cerevisiae, baker's yeast). In vitro studies using the mammalian alpha-glucosidase from rat intestine showed the extracts to be more effective in inhibiting maltase when compared to the acarbose control. Since acarbose is inactive against both the bacterial and the yeast enzymes, the extracts were compared to 1-deoxynojirimycin. We found all extracts to be more potent against alpha-glucosidase derived from B. stearothermophilus than that against the enzymes from either baker's yeast or rat intestine. In an in vivo study using Goto-Kakizaki (GK) rats, the acetone extract was found to be a potent inhibitor of alpha-glucosidase hydrolysis of maltose when compared to untreated control animals. Therefore, these results point to the inhibition of alpha-glucosidase as a possible mechanism by which this herb acts as an anti-diabetic agent.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/18374320
Author(s): Pietzsch M, Theuer S, Haase G, Plath F, Keyser M, et al.
Author(s): Boehme MW, Autschbach F, Ell C, Raeth U
Author(s): Masuda H, Inoue S, Arakawa H, Koizumi K, Kubo N
Author(s): Goldin E, Ardite E, Elizalde JI, Odriozola A, Panés J, et al.
Author(s): Korolkiewicz R, Tashima K, Kubomi M, Kato S, Takeuchi K
Author(s): Tashima K, Fujita A, Takeuchi K
Author(s): Brzozowska I, Targosz A, Sliwowski Z, Kwiecien S, Drozdowicz D, et al.
Author(s): Perdichizzi G, Bottari M, Pallio S, Fera MT, Carbone M, et al.
Author(s): Takehara K, Tashima K, Takeuchi K
Author(s): Tashima K, Korolkiewicz R, Kubomi M, Takeuchi K
Author(s): Iwai K, Kim MY, Onodera A, Matsue H
Author(s): Hung CR
Author(s): Mohan Kumar M, Joshi MC, Prabha T, Dorababu M, Goel RK
Author(s): Zhang LL, Lin YM
Author(s): Chaturvedi A, Bhawani G, Agarwal PK, Goel S, Singh A, et al.
Author(s): Broca C, Gross R, Petti P, Sauvaire Y, Manteghetti M, et al.
Author(s): Sima AA, Chakrabarti S
Author(s): Jose JK, Kuttan G, George J, Kuttan R
Author(s): Prabha T, Dora Babu M, Priyambada S, Agrawal VK, Goel RK
Author(s): Majumdar B, Ray Chaudhuri SG, Ray A, Bandyopadhyay SK
Author(s): Lowry CH, Roosebrough NJ, Farr AL, Randall RJ
Author(s): Link EM
Author(s): Nguyen KT, Ritz D, Gu JQ, Alexander D, Chu M, et al.
Author(s): Brzozowski T, Konturek PC, Konturek SJ, Kwiecién S, Pajdo R, et al.
Author(s): Ajeigbe KO, Olaleye SB, Oladejo EO, Olayanju AO
Author(s): Martin JP Jr
Author(s): Stevens MJ, Obrosova I, Cao X, Van Huysen C, Greene DA
Author(s): Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P
Author(s): Sakai M, Oimomi M, Kasuga M
Author(s): Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, et al.
Author(s): Jeong SM, Kang MJ, Choi HN, Kim JH, Kim JI
Author(s): Joshi MC, Dorababu M, Prabha T, Kumar MM, Goel RK
Author(s): Begum AN, Terao J
Author(s): Janisch KM, Williamson G, Needs P, Plumb GW
Author(s): Benherlal PS, Arumughan C
Author(s): Meyers KJ, Rudolf JL, Mitchell AE
Author(s): González-Segovia R, Quintanar JL, Salinas E, Ceballos-Salazar R, Aviles-Jiménez F, et al.