Author(s): Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK
As the human genome sequencing projects near completion, there is an active search for technologies that can provide insights into the genetic basis for physiological variation and interpreting gene expression in terms of phenotype at the whole organism level in order to understand the pathophysiology of disease. We present a novel metabonomic approach to the investigation of genetic influences on metabolic balance and metabolite excretion patterns in two phenotypically normal mouse models (C57BL10J and Alpk:ApfCD). Chemometric techniques were applied to optimise recovery of biochemical information from complex (1)H NMR urine spectra and to determine metabolic biomarker differences between the two strains. Differences were observed in tricarboxylic acid cycle intermediates and methylamine pathway activity. We suggest here a new 'metabotype' concept, which will be of value in relating quantitative physiological and biochemical data to both phenotypic and genetic variation in animals and man.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/11078872
Author(s): Atkins RC
Author(s): Steinke JM, Sinaiko AR, Kramer MS, Suissa S, Chavers BM, et al.
Author(s): Dronavalli S, Duka I, Bakris GL
Author(s): Fioretto P, Mauer M, Brocco E, Velussi M, Frigato F, et al.
Author(s): Hillege HL, Janssen WM, Bak AA, Diercks GF, Grobbee DE, et al.
Author(s): Jerums G, Premaratne E, Panagiotopoulos S, Clarke S, Power DA, et al.
Author(s): Zhang A, Sun H, Wang P, Han Y, Wang X
Author(s): Salek RM, Maguire ML, Bentley E, Rubtsov DV, Hough T, et al.
Author(s): Zhao L, Liu X, Xie L, Gao H, Lin D
Author(s): Zhao LC, Zhang XD, Liao SX, Gao HC, Wang HY, et al.
Author(s): Zhao X, Fritsche J, Wang J, Chen J, Rittig K, et al.
Author(s): Patterson AD, Bonzo JA, Li F, Krausz KW, Eichler GS, et al.
Author(s): Craig A, Cloarec O, Holmes E, Nicholson JK, Lindon JC
Author(s): Cone EJ, Caplan YH, Moser F, Robert T, Shelby MK, et al.
Author(s): Warrack BM, Hnatyshyn S, Ott KH, Reily MD, Sanders M, et al.
Author(s): Dai X, Kutschke K, Priest N
Author(s): Sheedy JR, Ebeling PR, Gooley PR, McConville MJ
Author(s): Boughton BA, Callahan DL, Silva C, Bowne J, Nahid A, et al.
Author(s): Dreier L, Wider G
Author(s): R Development Core Team
Author(s): Goodacre R, Broadhurst D, Smilde A, Kristal B, Baker J, et al.
Author(s): Xia J, Wishart DS
Author(s): Steuer R, Morgenthal K, Weckwerth W, Selbig J
Author(s): van den Berg RA, Hoefsloot HC, Westerhuis JA, Smilde AK, van der Werf MJ
Author(s): Shaffer JP
Author(s): Callow MJ, Dutoit S, Gong EL, Speed TP, Rubin EM
Author(s): Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, et al.
Author(s): Miller RC, Brindle E, Holman DJ, Shofer J, Klein NA, et al.
Author(s): Ng DP, Salim A, Liu Y, Zou L, Xu FG, et al.
Author(s): Griffin JL, Vidal-Puig A
Author(s): Vannini P, Marchesini G, Forlani G, Angiolini A, Ciavarella A, et al.
Author(s): Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, et al.
Author(s): Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, et al.
Author(s): Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, et al.
Author(s): Yuan W, Zhang J, Li S, Edwards JL
Author(s): Merheb M, Daher RT, Nasrallah M, Sabra R, Ziyadeh FN, et al.
Author(s): Kulakowski EC, Maturo J
Author(s): Waterfield CJ, Asker DS, Patel S, Timbrell JA
Author(s): Akira K, Masu S, Imachi M, Mitome H, Hashimoto T
Author(s): Gamagedara S, Shi H, Ma Y
Author(s): Lin S, Yang J, Wu G, Liu M, Luan X, et al.