Author(s): Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, et al.
Objective: Recently, several genes have been shown to be associated with an increased risk of type 2 diabetes by genome-wide association studies in white populations. To further investigate the involvement of these polymorphisms in conferring susceptibility to type 2 diabetes, we examined the association of 14 single nucleotide polymorphisms (SNPs) within 11 candidate loci with type 2 diabetes in a Japanese population.
Research design and methods: We analyzed 14 SNPs (rs4402960 in IGF2BP2, rs10811661 in CDKN2A/B, rs1111875 and rs7923837 in HHEX, rs13266634 in SLC30A8, rs1113132 and rs11037909 in EXT2, rs9939609 and rs8050136 in FTO, rs7756992 in CDKAL1, rs1801282 in PPARG Pro12Ara, rs5219 in KCNJ11 Glu23Lys, rs7480010 in LOC387761, and rs9300039 in Ch11) in 1,630 Japanese subjects with type 2 diabetes and in 1,064 control subjects by using an invader assay or a TaqMan assay.
Results: Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363). In this population, the remaining five loci were not significantly associated with type 2 diabetes. In addition, we identified significant association of the SNPs in FTO gene with BMI in the control subjects.
Conclusions: We have identified 6 of the 11 loci that were identified by genome-wide association studies in white populations, and these loci are considered strong candidates for type 2 diabetes susceptibility across different ethnicities.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/18162508
Author(s): Gerich JE
Author(s): Stumvoll M, Goldstein BJ, van Haeften TW
Author(s): Dey L, Attele AS, Yuan CS
Author(s): Chen L, Magliano DJ, Zimmet PZ
Author(s): International Diabetes Federation
Author(s): Harcourt BE, Penfold SA, Forbes JM
Author(s): Wild S, Roglic G, Green A, Sicree R, King H
Author(s): Shera AS, Jawad F, Maqsood A
Author(s): Tattersall RB, Fajans SS
Author(s): Shields BM, Hicks S, Shepherd MH, Colclough K, Hattersley AT, et al.
Author(s): Kanwal SF, Fazal S, Muhammad Ismail, Nighat Naureen
Author(s): Velho G, Robert JJ
Author(s): Ben Khelifa S, Barboura I, Dandana A, Ferchichi S, Miled A
Author(s): Pittman WB, Acton RT, Barger BO, Bell DS, Go RC, et al.
Author(s): Matejkova-Behanova M
Author(s): Nambam B, Aggarwal S, Jain A
Author(s): Gale EA
Author(s): Fourlanos S, Dotta F, Greenbaum CJ, Palmer JP, Rolandsson O, et al.
Author(s): Cervin C, Lyssenko V, Bakhtadze E, Lindholm E, Nilsson P, et al.
Author(s): Owen KR, McCarthy MI
Author(s): Doria A, Patti ME, Kahn CR
Author(s): Yang L, Zhou X, Luo Y, Sun X, Tang Y, et al.
Author(s): Wheeler E, Barroso I
Author(s): McCarthy MI, Zeggini E
Author(s): Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, et al.
Author(s): Prokopenko I, McCarthy MI, Lindgren CM
Author(s): Sanghera DK, Blackett PR
Author(s): Sladek R, Rocheleau G, Rung J, Dina C, Shen L, et al.
Author(s): Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, et al.
Author(s): Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al.
Author(s): Wellcome Trust Case Control Consortium
Author(s): Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, et al.
Author(s): Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, et al.
Author(s): Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al.
Author(s): Elbein SC, Das SK, Hallman DM, Hanis CL, Hasstedt SJ
Author(s): Ruchat SM, Elks CE, Loos RJ, Vohl MC, Weisnagel SJ, et al.
Author(s): Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, et al.
Author(s): Been LF, Ralhan S, Wander GS, Mehra NK, Singh J, et al.
Author(s): Rees SD, Hydrie MZ, Shera AS, Kumar S, O'Hare JP, et al.
Author(s): Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, et al.
Author(s): Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, et al.
Author(s): Parra EJ, Below JE, Krithika S, Valladares A, Barta JL, et al.
Author(s): Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH, et al.
Author(s): Xiang K, Wang Y, Zheng T, Jia W, Li J, et al.
Author(s): Das SK, Hasstedt SJ, Zhang Z, Elbein SC
Author(s): Love-Gregory LD, Wasson J, Ma J, Jin CH, Glaser B, et al.
Author(s): Silander K, Mohlke KL, Scott LJ, Peck EC, Hollstein P, et al.
Author(s): Helgason A, Pálsson S, Thorleifsson G, Grant SF, Emilsson V, et al.
Author(s): van Vliet-Ostaptchouk JV, Shiri-Sverdlov R, Zhernakova A, Strengman E, van Haeften TW, et al.
Author(s): van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, et al.
Author(s): Marquezine GF, Pereira AC, Sousa AG, Mill JG, Hueb WA, et al.
Author(s): Maeda S, Tsukada S, Kanazawa A, Sekine A, Tsunoda T, et al.
Author(s): Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, et al.
Author(s): Cho YM, Kim TH, Lim S, Choi SH, Shin HD, et al.
Author(s): Hu FB, Meigs JB, Li TY, Rifai N, Manson JE
Author(s): Moller DE
Author(s): Reitman ML, Schadt EE
Author(s): Holstein A, Seeringer A, Kovacs P
Author(s): Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, et al.
Author(s): Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, et al.
Author(s): Avery P, Mousa SS, Mousa SA
Author(s): Aquilante CL
Author(s): Distefano JK, Watanabe RM
Author(s): Lebovitz HE
Author(s): Schroner Z, Javorsky M, Kozarova M, Tkac I
Author(s): Wolford JK, Vozarova de Courten B
