Author(s): Yoshimura T, Yoshimura M, Tabata A, Shimasaki Y, Nakayama M, et al.
Objectives: A large number of studies suggest that abnormalities in nitric oxide (NO) synthesis may contribute to the development of preeclampsia. We recently identified a variant within exon 7 of the endothelial NO synthase (eNOS) gene: G to T conversion at nucleotide position 894 resulting in replacement of glutamic acid with aspartic acid at codon 298 (Glu298Asp). We analyzed the association between the Glu298Asp eNOS gene variant and preeclampsia.
Study design: The study included 152 preeclampsia patients (35 mild, 80 severe, and 37 superimposed) and 170 control subjects. Screening for the Glu298Asp eNOS gene variant was carried out by analysis of polymerase chain reaction-restriction fragment length polymorphism.
Results: The frequency of the Glu298Asp variant was significantly higher in the severe preeclampsia group (28.8%) than in the control (14.1%; p <. 01), superimposed preeclampsia (8.1%; p <.01), and mild preeclampsia (11.4%; p <.01) groups.
Conclusions: We conclude that the presence of the Glu298Asp eNOS gene could be a marker of increased risk of developing severe preeclampsia.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/10964023
Author(s): Holzer SE, Camerota A, Martens L, Cuerdon T, Crystal-Peters J, et al.
Author(s): Burdon KP, Langefeld CD, Wagenknecht LE, Carr JJ, Freedman BI, et al.
Author(s): Moncada S, Higgs A
Author(s): Loscalzo J, Welch G
Author(s): Cooke JP, Tsao PS
Author(s): Star RA
Author(s): Garg UC, Hassid A
Author(s): Prabhakar SS
Author(s): Nakagawa T, Sato W, Glushakova O, Heinig M, Clarke T, et al.
Author(s): Boulton AJ
Author(s): Taverna MJ, Elgrably F, Selmi H, Selam JL, Slama G
Author(s): Costacou T, Chang Y, Ferrell RE, Orchard TJ
Author(s): Brouet A, Sonveaux P, Dessy C, Balligand JL, Feron O
Author(s): Nosikov VV
Author(s): Bazzaz JT, Amoli MM, Pravica V, Chandrasecaran R, Boulton AJ, et al.
Author(s): Taverna MJ, Sola A, Guyot-Argenton C, Pacher N, Bruzzo F, et al.
Author(s): Manea SA, Robciuc A, Guja C, Heltianu C
Author(s): Mehrab-Mohseni M, Tabatabaei-Malazy O, Hasani-Ranjbar S, Amiri P, Kouroshnia A, et al.
Author(s): Wild S, Roglic G, Green A, Sicree R, King H
Author(s): Basu A, Mukherjee N, Roy S, Sengupta S, Banerjee S, et al.
Author(s): Shimasaki Y, Yasue H, Yoshimura M, Nakayama M, Kugiyama K, et al.
Author(s): Wang XL, Sim AS, Badenhop RF, McCredie RM, Wilcken DE
Author(s): Lepoivre M, Chenais B, Yapo A, Lemaire G, Thelander L, et al.
Author(s): Hattersley AT, McCarthy MI
Author(s): Ahluwalia TS, Ahuja M, Rai TS, Kohli HS, Sud K, et al.
Author(s): Neale BM, Sham PC
Author(s): Ross R
Author(s): Zanchi A, Moczulski DK, Hanna LS, Wantman M, Warram JH, et al.
Author(s): Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, et al.
Author(s): Hibi K, Ishigami T, Tamura K, Mizushima S, Nyui N, et al.
Author(s): Miyamoto Y, Saito Y, Kajiyama N, Yoshimura M, Shimasaki Y, et al.
Author(s): Cheema BS, kohli HS, Sharma R, Bhansali A, Khullar M