Author(s): Vannini P, Marchesini G, Forlani G, Angiolini A, Ciavarella A, et al.
Alterations in plasma branched-chain amino acids (valine, isoleucine and leucine) and alanine have been described in patients with insulin-dependent diabetes mellitus who have poor metabolic control. To assess the relevance of these abnormalities as indices of metabolic control, we sequentially evaluated plasma amino acids in 14 poorly controlled diabetics (seven Type 1 (insulin-dependent) and seven Type 2 (non-insulin-dependent) patients) until good control was achieved. The sum of branched-chain amino acids in both groups of uncontrolled diabetic patients was significantly increased compared with the values for the same subjects in good metabolic control. No statistically significant differences were present between ketotic and non-ketotic uncontrolled patients. The amelioration of the diabetic state with either insulin treatment or oral hypoglycaemic agents, reduced progressively branched-chain amino acids. The sum of valine, isoleucine and leucine strictly correlated with daily urinary glucose (r = 0.73), but less well with fasting blood glucose (r = 0.43), non-esterified fatty acids (r = 0.46) and glycosylated haemoglobin (r = 0.38). Alanine did not show any statistically significant differences at various stages of diabetic control. Branched-chain amino acids, but not alanine, may be used as indices of short-term diabetic control.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/6804294
Author(s): Atkins RC
Author(s): Steinke JM, Sinaiko AR, Kramer MS, Suissa S, Chavers BM, et al.
Author(s): Dronavalli S, Duka I, Bakris GL
Author(s): Fioretto P, Mauer M, Brocco E, Velussi M, Frigato F, et al.
Author(s): Hillege HL, Janssen WM, Bak AA, Diercks GF, Grobbee DE, et al.
Author(s): Jerums G, Premaratne E, Panagiotopoulos S, Clarke S, Power DA, et al.
Author(s): Zhang A, Sun H, Wang P, Han Y, Wang X
Author(s): Salek RM, Maguire ML, Bentley E, Rubtsov DV, Hough T, et al.
Author(s): Zhao L, Liu X, Xie L, Gao H, Lin D
Author(s): Zhao LC, Zhang XD, Liao SX, Gao HC, Wang HY, et al.
Author(s): Zhao X, Fritsche J, Wang J, Chen J, Rittig K, et al.
Author(s): Patterson AD, Bonzo JA, Li F, Krausz KW, Eichler GS, et al.
Author(s): Craig A, Cloarec O, Holmes E, Nicholson JK, Lindon JC
Author(s): Cone EJ, Caplan YH, Moser F, Robert T, Shelby MK, et al.
Author(s): Warrack BM, Hnatyshyn S, Ott KH, Reily MD, Sanders M, et al.
Author(s): Dai X, Kutschke K, Priest N
Author(s): Sheedy JR, Ebeling PR, Gooley PR, McConville MJ
Author(s): Boughton BA, Callahan DL, Silva C, Bowne J, Nahid A, et al.
Author(s): Dreier L, Wider G
Author(s): R Development Core Team
Author(s): Goodacre R, Broadhurst D, Smilde A, Kristal B, Baker J, et al.
Author(s): Xia J, Wishart DS
Author(s): Steuer R, Morgenthal K, Weckwerth W, Selbig J
Author(s): van den Berg RA, Hoefsloot HC, Westerhuis JA, Smilde AK, van der Werf MJ
Author(s): Shaffer JP
Author(s): Callow MJ, Dutoit S, Gong EL, Speed TP, Rubin EM
Author(s): Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, et al.
Author(s): Miller RC, Brindle E, Holman DJ, Shofer J, Klein NA, et al.
Author(s): Ng DP, Salim A, Liu Y, Zou L, Xu FG, et al.
Author(s): Griffin JL, Vidal-Puig A
Author(s): Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK
Author(s): Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, et al.
Author(s): Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, et al.
Author(s): Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, et al.
Author(s): Yuan W, Zhang J, Li S, Edwards JL
Author(s): Merheb M, Daher RT, Nasrallah M, Sabra R, Ziyadeh FN, et al.
Author(s): Kulakowski EC, Maturo J
Author(s): Waterfield CJ, Asker DS, Patel S, Timbrell JA
Author(s): Akira K, Masu S, Imachi M, Mitome H, Hashimoto T
Author(s): Gamagedara S, Shi H, Ma Y
Author(s): Lin S, Yang J, Wu G, Liu M, Luan X, et al.