Effect of exercise training on plasma visfatin and eotaxin levels

Author(s): Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, et al.


Objective: Visfatin, a novel adipokine, was revealed to be associated with obesity and to have insulin-mimetic effect. Eotaxin, which is an important chemokine in asthma, was recently reported to be associated with obesity in mice and humans. We evaluated the effect of exercise training on plasma visfatin and eotaxin levels in association with cardiovascular risk factors.

Design: Forty-eight non-diabetic Korean women were evaluated before and after a 12 week exercise program including aerobic exercise (45 min/session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) five times per week.

Results: Plasma visfatin concentrations were elevated in obese subjects (body mass index, BMI> or =25 kg/m2) when compared with non-obese subjects (16.4 +/- 13.4 ng/ml vs 7.7 +/- 5.2 ng/ml, P = 0.006), and eotaxin concentrations were elevated in subjects with central obesity (waist circumference, WC> or =80 cm) when compared with those without central obesity (73.6 +/- 17.8 pg/ml vs 64.2 +/- 4.2 pg/ml, P = 0.005). In multiple regression analyses, visfatin levels were associated with BMI (R2 = 0.255) and eotaxin levels were associated with WC and body weight (R2 = 0.307). After the exercise program, body weight, blood pressure, fasting glucose, and insulin resistance of participants were decreased. Furthermore, plasma visfatin levels were significantly decreased from 13.6 +/- 12.0 to 7.7 +/- 7.9 ng/ml (P = 0.026) and eotaxin levels were reduced from 72.0 +/- 16.7 to 66.9 +/- 14.2 pg/ml (P = 0.018).

Conclusions: Exercise training with weight loss induced a significant reduction of plasma visfatin and eotaxin levels in non-diabetic Korean women.

Similar Articles

Visfatin/PBEF and Atherosclerosis-Related Diseases

Author(s): Filippatos TD, Randeva HS, Derdemezis CS, Elisaf MS, Mikhailidis DP

Age of onset and type of diabetes

Author(s): Laakso M, Pyorala K

Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients

Author(s): Derosa G, Maffioli P, Salvadeo SA, Ferrari I, Gravina A, et al.

Leptin increase is associated with markers of the hemostatic system in obese healthy women

Author(s): Guagnano MT, Romano M, Falco A, Nutini M, Marinopiccoli M, et al.

Plasma visfatin concentration as a surrogate marker for visceral fat accumulation in obese children

Author(s): Araki S, Dobashi K, Kubo K, Kawagoe R, Yamamoto Y, et al.

An evaluation of visfatin levels in obese subjects

Author(s): Kaminska A, Kopczynska E, Bronisz A, Zmudzinska M, Bielinski M, et al.

Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding

Author(s): Haider DG, Schindler K, Schaller G, Prager G, Wolzt M, et al.

Plasma visfatin concentrations in severely obese subjects are increased after intestinal bypass

Author(s): García-Fuentes E, García-Almeida JM, García-Arnés J, García-Serrano S, Rivas-Marín J, et al.

The visfatin gene is associated with glucose and lipid metabolism in a Chinese population

Author(s): Jian WX, Luo TH, Gu YY, Zhang HL, Zheng S et al.

Serum visfatin increases with progressive beta-cell deterioration

Author(s): López-Bermejo A, Chico-Julià B, Fernàndez-Balsells M, Recasens M, Esteve E, et al.

Adipose tissue as an endocrine organ

Author(s): Kershaw EE, Flier JS

Obesity, hypertension and insulin resistance

Author(s): Sharma AM, Chetty VT

Regulation of adipocytokines and insulin resistance

Author(s): Fasshauer M, Paschke R