Effect of glycemic control, race (white versus black), and duration of diabetes on reduced glutathione content in erythrocytes of diabetic patients

Author(s): Jain SK, McVie R


We designed this study to examine whether uncontrolled hyperglycemia, duration of diabetes, or race (black v white) have any effect on glutathione levels in erythrocytes of type I diabetic patients. Hyperglycemia was assessed by measuring the level of hemoglobin A1c (HbA1c). Results show that erythrocytes of diabetic patients have a significantly lower glutathione level compared with those of age-matched normal subjects (P < .004). We found a significant negative correlation (r = -.59, P < .001) between the degree of hyperglycemia and the level of reduced glutathione (GSH) in erythrocytes of diabetic patients. There was no significant relationship (r = -.29, P > .12) between the level of GSH in erythrocytes and the duration of diabetes. Erythrocytes of black diabetic patients had significantly lower levels of GSH (P < .05) than those of white diabetic patients. Using erythrocytes as a model, this study suggests that a lower level of GSH may have a role in the cellular damage and impaired insulin secretion in uncontrolled diabetic patients.

Similar Articles

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

Author(s): Wild S, Roglic G, Green A, Sicree R, King H

Oxidative stress, nitric oxide, and diabetes

Author(s): Pitocco D, Zaccardi F, Di Stasio E, Romitelli F, Santini SA, et al.

Oxidative stress, diabetes, and diabetic complications

Author(s): Wei W, Liu Q, Tan Y, Liu L, Li X, et al.

Selenium: biochemical role as a component of glutathione peroxidase

Author(s): Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, et al.

Metal sites of copper-zinc superoxide dismutase

Author(s): Beem KM, Richardson DC, Rajagopalan KV

An iron-based cytosolic catalase and superoxide dismutase mimic complex

Author(s): Horn A Jr, Parrilha GL, Melo KV, Fernandes C, Horner M, et al.

The protective effect of montelukast sodium on carbon tetrachloride induced hepatopathy in rat

Author(s): Cuciureanu M, Caruntu ID, Paduraru O, Stoica B, Jerca L, et al.

A bicarbonate-alkaline mineral water protects from ethanol-induced hemorrhagic gastric lesions in mice

Author(s): Nassini R, Andrè E, Gazzieri D, De Siena G, Zanasi A, et al.

Anti-diabetic effect of alkaline-reduced water on OLETF rats

Author(s): Jin D, Ryu SH, Kim HW, Yang EJ, Lim SJ, et al.

Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage

Author(s): Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, et al.

Haemoglobin A1c levels and subsequent cardiovascular disease in persons without diabetes: a meta-analysis of prospective cohorts

Author(s): Santos-Oliveira R, Purdy C, da Silva MP, dos Anjos Carneiro-Leão AM, Machado M, et al.