Author(s): Miyashita Y, Endo K, Saiki A, Ban N, Yamaguchi T, et al.
Aim: A novel device has been developed for measuring the cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. In this study, we evaluated the effect of pitavastatin on CAVI in type 2 diabetic patients.
Methods: Forty-five type 2 diabetes mellitus patients with low-density lipoprotein cholesterolemia were enrolled and treated with pitavastatin 2 mg/day for 12 months. Before and after pitavastatin administration, HbA1c, serum lipids, serum malondialdehyde-LDL (MDA-LDL), urinary 8-hydroxy- 2'-deoxyguanosine (8-OHdG) and CAVI were measured.
Results: After pitavastatin treatment for 12 months, significant decreases in 8-OHdG, MDA-LDL and CAVI were observed. DeltaCAVI significantly correlated with DeltaMDA-LDL.
Conclusions: In type 2 diabetic patients, pitavastatin may have an oxidative stress-reducing effect, especially in a state of enhanced oxidative stress, and CAVI may be useful as a routine test for the diagnosis and therapeutic monitoring of atherosclerosis.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/19907100
Author(s): Cholesterol Treatment Trialists’ (CTT) Collaboration, Baigent C, Blackwell L, Emberson J, Holland LE, et al.
Author(s): Freeman DJ, Norrie J, Sattar N, Neely RD, Cobbe SM, et al.
Author(s): Coleman CI, Reinhart K, Kluger J, White CM
Author(s): Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, et al.
Author(s): Baker WL, Talati R, White CM, Coleman CI
Author(s): Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, et al.
Author(s): Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al.
Author(s): DeFronzo RA, Tobin JD, Andres R
Author(s): Koshiyama H, Taniguchi A, Tanaka K, Kagimoto S, Fujioka Y, et al.
Author(s): Sakabe K, Fukuda N, Fukuda Y, Wakayama K, Nada T, et al.
Author(s): Inami N, Nomura S, Shouzu A, Omoto S, Kimura Y, et al.
Author(s): Nakata M, Nagasaka S, Kusaka I, Matsuoka H, Ishibashi S, et al.
Author(s): Yada T, Nakata M, Shiraishi T, Kakei M
Author(s): Ishihara Y, Ohmori K, Mizukawa M, Hasan AU, Noma T, et al.
Author(s): Yamazaki T, Kishimoto J, Ito C, Noda M, Odawara M, et al.