Author(s): Kim JM, Yoon M, Kang I, Kim SS, Ha J
The present work was performed to identify the possible roles of acetyl-CoA carboxylase isoforms (ACC-alpha and ACC-beta). Two forms show 70% amino acid identity, but N-terminal regions share no homology, indicating that these may be uniquely related to the specific role of each ACC form. Thus, we investigated whether introduction of the exogenous ACC N-terminus into H9c2 cardiomyocytes that express both ACC forms causes a noticeable change in a specific pathway of fatty acid metabolism. The effect of ACC-alpha N-terminus overexpression was specific to the fatty acid synthesis rate resulting in an 80% induction, whereas overexpression of the ACC-beta N-terminus increased fatty acid oxidation rate 50% without affecting the fatty acid synthesis rate. These results suggest that ACC-alpha and beta are involved in the regulation of fatty acid synthesis and oxidation, respectively, and that the N-terminus plays an important role in the process. We further demonstrated that novel proteins specifically bound to the ACC N-terminus. This interaction may mediate the involvement of each ACC form in different cellular activities.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/9703953
Author(s): Bournat JC, Brown CW
Author(s): Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al.
Author(s): Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM
Author(s): Midaoui AE, Elimadi A, Wu L, Haddad PS, de Champlain J
Author(s): Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, et al.
Author(s): Konrad T, Vicini P, Kusterer K, Höflich A, Assadkhani A, et al.
Author(s): Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Barber A, Martínez JA, et al.
Author(s): Cicchillo RM, Booker SJ
Author(s): Yi X, Maeda N
Author(s): Navarro-Sastre A, Tort F, Stehling O, Uzarska MA, Arranz JA, et al.
Author(s): Mayr JA, Zimmermann FA, Fauth C, Bergheim C, Meierhofer D, et al.
Author(s): Padmalayam I, Hasham S, Saxena U, Pillarisetti S
Author(s): Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al.
Author(s): Gulick T, Cresci S, Caira T, Moore DD, Kelly DP
Author(s): Jbilo O, Ravinet-Trillou C, Arnone M, Buisson I, Bribes E
Author(s): Ravinet Trillou C, Arnone M, Delgorge C, Gonalons N, Keane P, et al.
Author(s): Soares AF, Guichardant M, Cozzone D, Bernoud-Hubac N, Bouzaïdi-Tiali N
Author(s): Katsuki A, Suematsu M, Gabazza EC, Murashima S, Nakatani K, et al.
Author(s): Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, et al.
Author(s): Padmalayam I
Author(s): Cardinal P, Bellocchio L, Clark S, Cannich A, Klugmann M, et al.
Author(s): Addy C, Wright H, Van Laere K, Gantz I, Erondu N, et al.
Author(s): Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, et al.
Author(s): Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, et al.
Author(s): Li B, Nolte LA, Ju JS, Han DH, Coleman T
Author(s): Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, et al.
Author(s): Faraut B, Giannesini B, Matarazzo V, Le Fur Y, Rougon G, et al
Author(s): Pavón FJ, Serrano A, Pérez-Valero V, Jagerovic N, Hernández-Folgado L, et al.
Author(s): Kelley DE, He J, Menshikova EV, Ritov VB
Author(s): Conley KE, Jubrias SA, Esselman PC
Author(s): Rooyackers OE, Adey DB, Ades PA, Nair KS
Author(s): Chabi B, Ljubicic V, Menzies KJ, Huang JH, Saleem A, et al.
Author(s): Park SW, Goodpaster BH, Lee JS, Kuller LH, Boudreau R, et al.
Author(s): Park SW, Goodpaster BH, Strotmeyer ES, Kuller LH, Broudeau R, et al.
Author(s): St-Onge MP
Author(s): Ritov VB, Menshikova EV, Azuma K, Wood R, Toledo FG, et al.
Author(s): Djouadi F, Aubey F, Schlemmer D, Bastin J
Author(s): Poynten AM, Markovic TP, Maclean EL, Furler SM, Freund J, et al.
Author(s): Ginsberg HN