Gastric infection by Helicobacter pylori and antral gastritis in hyperglycemic obese and in diabetic subjects

Author(s): Perdichizzi G, Bottari M, Pallio S, Fera MT, Carbone M, et al.


The aim of this work was to ascertain if diabetes and obesity can affect gastric colonization by Helicobacter pylori. 59 hospitalized subjects with dyspepsia and endoscopic antral gastritis were selected. They were divided into three groups: I) 13 patients with normal body weight and without disease other than gastritis (control group); II) 15 patients with essential obesity of whom 10 had impaired glucose tolerance (IGT); III) 31 patients with type II diabetes mellitus, of whom 14 were obese. Three gastric biopsies were obtained from each patient for histologic examination and H. pylori detection by means of rapid urea test, culture and histological evidence of Helicobacter-Like Organisms (HLO). Age, sex, blood glucose, cholesterol, triglycerides, HDL-cholesterol, basal gastrine, duration of illness, body weight were statistically analysed. Differences between the three groups were not statistically significant. There was a higher prevalence of H. pylori infection both in obese and in diabetic patients with respect to control subjects. Prevalence became still higher in obese patients with impaired glucose tolerance. Among the three tests used for the detection of H. pylori, culture and rapid urea were reliable and specific, while the histologic test was highly sensitive but barely specific. Our data suggest that both obesity and type II diabetes may be associated with an increased incidence of H. pylori-colonization. This could be related to the reduced gastric motility observed in both pathologies and chemical changes in gastric mucosa following non-enzymatic glycosylation processes.

Similar Articles

Peptic ulcer in diabetes mellitus

Author(s): Masuda H, Inoue S, Arakawa H, Koizumi K, Kubo N

Gastric mucosal damage in experimental diabetes in rats: role of endogenous glutathione

Author(s): Goldin E, Ardite E, Elizalde JI, Odriozola A, Panés J, et al.

Increased susceptibility of diabetic rat gastric mucosa to food deprivation during cold stress

Author(s): Korolkiewicz R, Tashima K, Kubomi M, Kato S, Takeuchi K

4-Hydroxyisoleucine Experimental evidence of its insulinotropic and antidiabetic properties

Author(s): Broca C, Gross R, Petti P, Sauvaire Y, Manteghetti M, et al.

Antimutagenic and anticarcinogenic activity of Emblica officinalis

Author(s): Jose JK, Kuttan G, George J, Kuttan R

Protein measurement with the folin phenol reagent

Author(s): Lowry CH, Roosebrough NJ, Farr AL, Randall RJ

Combinatorial biosynthesis of novel antibiotics related to daptomycin

Author(s): Nguyen KT, Ritz D, Gu JQ, Alexander D, Chu M, et al.

Involvement of endogenous cholecystokinin and somatostatin in gastroprotection induced by intraduodenal fat

Author(s):  Brzozowski T, Konturek PC, Konturek SJ, Kwiecién S, Pajdo R, et al.

A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat

Author(s): Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, et al.

Alpha-glucosidase inhibitory activity of Syzygium cumini (Linn

Author(s): Shinde J, Taldone T, Barletta M, Kunaparaju N, Hu B, et al.

Influence of dietary quercetin on glutathione redox status in mice

Author(s): Meyers KJ, Rudolf JL, Mitchell AE

Effect of the flavonoid quercetin on inflammation and lipid peroxidation induced by Helicobacter pylori in gastric mucosa of guinea pig

Author(s): González-Segovia R, Quintanar JL, Salinas E, Ceballos-Salazar R, Aviles-Jiménez F, et al.