Author(s): Tamrakar AK, Yadav PP, Tiwari P, Maurya R, Srivastava AK
Aim of the study: To identify pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits.
Material and methods: Streptozotocin-induced diabetic rats and hyperglycemic, hyperlipidemic and hyperinsulinemic db/db mice were used to investigate the antihyperglycemic activity of pongamol and karangin isolated from the fruits of Pongamia pinnata.
Results: In streptozotocin-induced diabetic rats, single dose treatment of pongamol and karanjin lowered the blood glucose level by 12.8% (p<0.05) and 11.7% (p<0.05) at 50mg /kg dose and 22.0% (p<0.01) and 20.7% (p<0.01) at 100mg/kg dose, respectively after 6h post-oral administration. The compounds also significantly lowered blood glucose level in db/db mice with percent activity of 35.7 (p<0.01) and 30.6 (p<0.01), respectively at 100mg/kg dose after consecutive treatment for 10 days. The compounds were observed to exert a significant inhibitory effect on enzyme protein tyrosine phosphatase-1B (EC 3.1.3.48).
Conclusion: The results showed that pongamol and karangin isolated from the fruits of Pongamia pinnata possesses significant antihyperglycemic activity in Streptozotocin-induced diabetic rats and type 2 diabetic db/db mice and protein tyrosine phosphatase-1B may be the possible target for their activity.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/18572336
Author(s): King H, Aubert RE, Herman WH
Author(s): Carroll MF, Gutierrez A, Castro M, Tsewang D, Schade DS
Author(s): Slama G, Elgrably F, Sola A, Mbemba J, Larger E
Author(s): Ross SA, Gulve EA, Wang M
Author(s): Chiasson JL, Rabasa-Lhoret R
Author(s): Yabe-Nishimura C
Author(s): Engerman RL, Kern TS
Author(s): Grover JK, Yadav S, Vats V
Author(s): Misar A, Bhagat R, Mujumdar AM
Author(s): Kambizi L, Afolayan AJ
Author(s): Singh BN, Singh BR, Singh RL, Prakash D, Sarma BK, et al.
Author(s): Asad M, Munir TA, Afzal N
Author(s): Matsui T, Yoshimoto C, Osajima K, Oki T, Osajima Y
Author(s): Hanefeld M, Fischer S, Julius U, Schulze J, Schwanebeck U, et al.
Author(s): Casirola DM, Ferraris RP
Author(s): Toeller M
Author(s): Matsuda H, Murakami T, Yashiro K, Yamahara J, Yoshikawa M
Author(s): Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, et al.
Author(s): Kashyap SR, Defronzo RA
Author(s): Dixit BL, Balendiran GK, Watowich SJ, Srivastava S, Ramana KV, et al.
Author(s): Ramana KV, Dixit BL, Srivastava S, Bhatnagar A, Balendiran GK, et al.
Author(s): Aurell M, Bjorck S
Author(s): Shinde UA, Goyal RK
