Author(s): Sakamoto A, Ishizaka Y, Toda E, Nagai R, Koike K, et al.
Aim: Changes in indexes of obesity, such as waist circumference (WC) and body mass index (BMI), may influence some glucose metabolism-related parameters in both obese and non-obese subjects. We have investigated the impact of changes in WC and in BMI on data related to glucose metabolism over a one-year period.
Methods: Data from 3213 individuals (2014 men, 1199 women) who underwent a general health screening two years running and were not taking antidiabetic medication were analyzed.
Results: In men, percent changes in WC (%dWC) and BMI (%dBMI) were both significantly correlated with percent changes in fasting glucose (%dFG), in hemoglobin A(1C) (%dHbA(1C)), and in HOMA-IR (%dHOMA-IR). In women, these relationships were not significant except for the relationship between %dBMI and %dHOMA-IR. In a multivariate linear regression analysis using age, %dBMI, and %dWC as independent variables, %dBMI, but not %dWC, was found to be an independent predictor of %dHOMA-IR in both genders. Furthermore, in men, %dBMI was also an independent factor predicting %dFG and %dHbA(1C).
Conclusion: During the one-year period, a reduction in BMI, and thus weight loss, was found to be associated with the improvement of insulin sensitivity, especially in men. A reduction in WC was also associated with an improvement in insulin sensitivity in men; however, this relationship did not remain significant after controlling for changes in BMI.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/20877140
Author(s): Arner P
Author(s): Chen MP, Chung FM, Chang DM, Tsai JC, Huang HF, et al.
Author(s): Fantuzzi G
Author(s): Filippatos TD, Randeva HS, Derdemezis CS, Elisaf MS, Mikhailidis DP
Author(s): Adeghate E
Author(s): Alberti KG, Zimmet PZ
Author(s): Laakso M, Pyorala K
Author(s): Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al.
Author(s): Kim MK, Lee JH, Kim H, Park SJ, Kim SH, et al.
Author(s): Derosa G, Maffioli P, Salvadeo SA, Ferrari I, Gravina A, et al.
Author(s): Guagnano MT, Romano M, Falco A, Nutini M, Marinopiccoli M, et al.
Author(s): Choi KM, Kim JH, Cho GJ, Baik SH, Park HS, et al.
Author(s): Araki S, Dobashi K, Kubo K, Kawagoe R, Yamamoto Y, et al.
Author(s): Kim JH, Kim SH, Im JA, Lee DC
Author(s): Pfutzner A, Hanefeld M, Lübben G, Weber MM, Karagiannis E, et al.
Author(s): Kaminska A, Kopczynska E, Bronisz A, Zmudzinska M, Bielinski M, et al.
Author(s): Haider DG, Schindler K, Schaller G, Prager G, Wolzt M, et al.
Author(s): García-Fuentes E, García-Almeida JM, García-Arnés J, García-Serrano S, Rivas-Marín J, et al.
Author(s): Chang YH, Chang DM, Lin KC, Shin SJ, Lee YJ
Author(s): Pagano C, Pilon C, Olivieri M, Mason P, Fabris R, et al.
Author(s): Jian WX, Luo TH, Gu YY, Zhang HL, Zheng S et al.
Author(s): López-Bermejo A, Chico-Julià B, Fernàndez-Balsells M, Recasens M, Esteve E, et al.
Author(s): Kershaw EE, Flier JS
Author(s): Sharma AM, Chetty VT
Author(s): Fasshauer M, Paschke R