Author(s): Midaoui AE, Elimadi A, Wu L, Haddad PS, de Champlain J
Background: The present study was designed to investigate whether the effects of dietary supplementation with alpha-lipoic acid could prevent the increase in mitochondrial superoxide production in the heart as well as the enhanced formation of advanced glycation end-products (AGE) that are associated with the development of hypertension and insulin resistance in chronically glucose-fed rats.
Methods: Sprague Dawley rats were either given or not given a 10% D-glucose solution to drink during 4 weeks, combined either with a normal chow diet or with alpha-lipoic acid supplemented diet. The oxidative stress was evaluated by measuring the heart mitochondrial superoxide production using the lucigenin chemiluminescence method. The formation of AGE was also assessed in plasma and aorta.
Results: Chronic administration of glucose resulted in a 29% increase in blood pressure, 30% increase in glycemia, 286% increase in insulinemia, and 408% increase in insulin resistance index. Chronic glucose feeding also resulted in a 22% greater mitochondrial superoxide anion production in heart and in an increase of 63% in AGE content in aorta. Increases in blood pressure, aorta AGE content and heart mitochondrial superoxide production were prevented in the rats fed glucose supplemented with lipoic acid. The simultaneous treatment with lipoic acid also attenuated the rise in insulin levels as well as in insulin resistance in the glucose fed rats.
Conclusions: These findings demonstrate that alpha-lipoic acid supplementation prevents development of hypertension and hyperglycemia, presumably through its antioxidative properties, as reflected by prevention of an increase in heart mitochondrial superoxide anion production and in AGE formation in the aorta of chronically glucose treated rats.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/12620694
Author(s): Bournat JC, Brown CW
Author(s): Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al.
Author(s): Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM
Author(s): Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, et al.
Author(s): Konrad T, Vicini P, Kusterer K, Höflich A, Assadkhani A, et al.
Author(s): Prieto-Hontoria PL, Pérez-Matute P, Fernández-Galilea M, Barber A, Martínez JA, et al.
Author(s): Cicchillo RM, Booker SJ
Author(s): Yi X, Maeda N
Author(s): Navarro-Sastre A, Tort F, Stehling O, Uzarska MA, Arranz JA, et al.
Author(s): Mayr JA, Zimmermann FA, Fauth C, Bergheim C, Meierhofer D, et al.
Author(s): Padmalayam I, Hasham S, Saxena U, Pillarisetti S
Author(s): Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al.
Author(s): Gulick T, Cresci S, Caira T, Moore DD, Kelly DP
Author(s): Kim JM, Yoon M, Kang I, Kim SS, Ha J
Author(s): Jbilo O, Ravinet-Trillou C, Arnone M, Buisson I, Bribes E
Author(s): Ravinet Trillou C, Arnone M, Delgorge C, Gonalons N, Keane P, et al.
Author(s): Soares AF, Guichardant M, Cozzone D, Bernoud-Hubac N, Bouzaïdi-Tiali N
Author(s): Katsuki A, Suematsu M, Gabazza EC, Murashima S, Nakatani K, et al.
Author(s): Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, et al.
Author(s): Padmalayam I
Author(s): Cardinal P, Bellocchio L, Clark S, Cannich A, Klugmann M, et al.
Author(s): Addy C, Wright H, Van Laere K, Gantz I, Erondu N, et al.
Author(s): Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, et al.
Author(s): Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, et al.
Author(s): Li B, Nolte LA, Ju JS, Han DH, Coleman T
Author(s): Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, et al.
Author(s): Faraut B, Giannesini B, Matarazzo V, Le Fur Y, Rougon G, et al
Author(s): Pavón FJ, Serrano A, Pérez-Valero V, Jagerovic N, Hernández-Folgado L, et al.
Author(s): Kelley DE, He J, Menshikova EV, Ritov VB
Author(s): Conley KE, Jubrias SA, Esselman PC
Author(s): Rooyackers OE, Adey DB, Ades PA, Nair KS
Author(s): Chabi B, Ljubicic V, Menzies KJ, Huang JH, Saleem A, et al.
Author(s): Park SW, Goodpaster BH, Lee JS, Kuller LH, Boudreau R, et al.
Author(s): Park SW, Goodpaster BH, Strotmeyer ES, Kuller LH, Broudeau R, et al.
Author(s): St-Onge MP
Author(s): Ritov VB, Menshikova EV, Azuma K, Wood R, Toledo FG, et al.
Author(s): Djouadi F, Aubey F, Schlemmer D, Bastin J
Author(s): Poynten AM, Markovic TP, Maclean EL, Furler SM, Freund J, et al.
Author(s): Ginsberg HN