Author(s): Hamilton G, Smith DL Jr, Bydder M, Nayak KS, Hu HH
Purpose: To explore the MR signatures of brown adipose tissue (BAT) compared with white adipose tissue (WAT) using single-voxel MR spectroscopy.
Materials and methods: (1) H MR STEAM spectra were acquired from a 3 Tesla clinical whole body scanner from seven excised murine adipose tissue samples of BAT (n=4) and WAT (n=3). Spectra were acquired at multiple echo times (TEs) and inversion times (TIs) to measure the T1, T2, and T2-corrected peak areas. A theoretical triglyceride model characterized the fat in terms of number of double bonds (ndb) and number of methylene-interrupted double bonds (nmidb).
Results: Negligible differences between WAT and BAT were seen in the T1 and T2 of fat and the T2 of water. However, the water fraction in BAT was higher (48.5%) compared with WAT (7.1%) and the T1 of water was lower in BAT (618 ms) compared with WAT (1053 ms). The fat spectrum also differed, indicating lower levels of unsaturated triglycerides in BAT (ndb=2.7, nmidb=0.7) compared with WAT (ndb=3.3, nmidb=1.0).
Conclusion: We have demonstrated that there are several key MR-based signatures of BAT and WAT that may allow differentiation on MR imaging.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/21780237
Author(s): Hulbert AJ, Else PL
Author(s): Hulbert AJ
Author(s): Hulbert AJ
Author(s): Sun Z, Boneschanscher MP, Swart I, Vanmaekelbergh D, Liljeroth P
Author(s): Kucerka N, Liu Y, Chu N, Petrache HI, Tristram-Nagle S, et al.
Author(s): Nagle JF, Tristram-Nagle S
Author(s): Rajamoorthi K, Petrache HI, McIntosh TJ, Brown MF
Author(s): Weijers RN
Author(s): Bouché C, Serdy S, Kahn CR, Goldfine AB
Author(s): Salas-Burgos A, Iserovich P, Zuniga F, Vera JC, Fischbarg J
Author(s): Shepherd PR, Kahn BB
Author(s): Marrink SJ, Mark AE
Author(s): Kelley DE, He J, Menshikova EV, Ritov VB
Author(s): Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI
Author(s): Petersen KF, Dufour S, Shulman GI
Author(s): Lohninger A, Radler U, Jinniate S, Lohninger S, Karlic H, et al.
Author(s): Boden G, Shulman GI
Author(s): Timmons JA, Baar K, Davidsen PK, Atherton PJ
Author(s): Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, et al.
Author(s): Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, et al.
Author(s): Nishida Y, Tokuyama K, Nagasaka S, Higaki Y, Shirai Y, et al.
Author(s): Pan XR, Li GW, Hu YH, Wang JX, Yang WY, et al.
Author(s): Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, et al.
Author(s): Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, et al.
Author(s): Cho YI, Mooney MP, Cho DJ
Author(s): Simons K, Gerl MJ
Author(s): Mitra K, Ubarretxena-Belandia I, Taguchi T, Warren G, Engelman DM