Perinatal outcomes associated with the use of glargine during pregnancy

Author(s): Di Cianni G, Torlone E, Lencioni C, Bonomo M, Di Benedetto A, et al.


Aims: Insulin glargine (IG), with its non-peaking action profile, might be useful in diabetic pregnancy. However, data on its safety are limited and its use during pregnancy is not recommended. This study focused on the effects of IG on perinatal outcome, particularly to estimate the rate of congenital anomalies and birthweight.

Methods: This retrospective study included women with pre-gestational diabetes who used IG before (at least 1 month) and during pregnancy. For all women we recorded data regarding maternal glycaemic control and pregnancy outcome. We also compared women treated with IG throughout pregnancy and women who stopped taking IG at an earlier stage.

Results: From 27 centres, 107 Type 1 diabetic pregnancies were identified. IG was started 10.3 +/- 6.9 months before conception and in 57.4% of cases was stopped during the first trimester; 42.6% of women continued using it until the end of pregnancy. There were six abortions (four spontaneous and two induced) and five newborns (4.9%) with congenital anomalies. Glycaemic control, birthweight and the prevalence of macrosomia and neonatal morbidity were similar in women who used IG for the full term compared with those who stopped IG earlier during pregnancy.

Conclusions: This study, although limited, suggests that IG is safe and effective; the rate of congenital malformations was within the range expected for diabetic pregnancies treated with more traditional forms of insulin. IG used throughout pregnancy did not seem to influence birthweight or increase adverse outcomes.

Similar Articles

Less hypoglycemia with insulin glargine in intensive insulin therapy for type 1 diabetes

Author(s): Ratner RE, Hirsch IB, Neifing JL, Garg SK, Mecca TE, et al.

Insulin analogues and their potential in the management of diabetes mellitus

Author(s): Bolli GB, Di Marchi RD, Park GD, Pramming S, Koivisto VA

Meta-analysis of the effect of insulin lispro on severe hypoglycemia in patients with type 1 diabetes

Author(s): Brunelle BL, Llewelyn J, Anderson JH Jr, Gale EA, Koivisto VA

Prevention of perinatal morbidity by tight metabolic control in gestational diabetes mellitus

Author(s): Drexel H, Bichler A, Sailer S, Breier C, Lisch HJ, et al.

Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use

Author(s): Kurtzhals P, Schäffer L, Sørensen A, Kristensen C, Jonassen I, et al.

Use of insulin glargine during pregnancy in a type 1 diabetic woman

Author(s): Devlin JT, Hothersall L, Wilkis JL

Insulin glargine use during pregnancy

Author(s): Pantalone KM, Faiman C, Olansky L

Perinatal outcomes in pregnancies managed with antenatal insulin glargine

Author(s): Egerman RS, Ramsey RD, Kao LW, Bringman JJ, Haerian H, et al.