Author(s): Shi Y, Vanhoutte PM
Vascular complications are an important pathological issue in diabetes that lead to the further functional deterioration of several organs. The balance between endothelium-dependent relaxing factors and endothelium-dependent contracting factors (EDCFs) is crucial in controlling local vascular tone and function under normal conditions. Diabetic endothelial dysfunction is characterized by reduced endothelium-dependent relaxations and/or enhanced endothelium-dependent contractions. Elevated levels of oxygen-derived free radicals are the initial source of endothelial dysfunction in diabetes. Oxygen-derived free radicals not only reduce nitric oxide bioavailability, but also facilitate the production and/or action of EDCFs. Thus, the endothelial balance tips towards vasoconstrictor responses over the course of diabetes.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/20923534
Author(s): Shaw JE, Sicree RA, Zimmet PZ
Author(s): Wild S, Roglic G, Green A, Sicree R, King H
Author(s): Elmarakby AA, Sullivan JC
Author(s): Tiganis T
Author(s): Pitocco D, Zaccardi F, Di Stasio E, Romitelli F, Santini SA, et al.
Author(s): Wei W, Liu Q, Tan Y, Liu L, Li X, et al.
Author(s): Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB
Author(s): Narayana K
Author(s): Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, et al.
Author(s): Beem KM, Richardson DC, Rajagopalan KV
Author(s): Horn A Jr, Parrilha GL, Melo KV, Fernandes C, Horner M, et al.
Author(s): Cuciureanu M, Caruntu ID, Paduraru O, Stoica B, Jerca L, et al.
Author(s): Nassini R, Andrè E, Gazzieri D, De Siena G, Zanasi A, et al.
Author(s): Huang KC, Yang CC, Lee KT, Chien CT
Author(s): Hofer T, Marzetti E, Xu J, Seo AY, Gulec S, et al.
Author(s): Jin D, Ryu SH, Kim HW, Yang EJ, Lim SJ, et al.
Author(s): Shomar B
Author(s): Johansson LH, Borg LA
Author(s): Wheeler CR, Salzman JA, Elsayed NM, Omaye ST, Korte DW Jr
Author(s): Baker MA, Cerniglia GJ, ZamanA
Author(s): Armstrong D, Browne R
Author(s): Liu D
Author(s): Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, et al.
Author(s): Hanaoka K
Author(s): Lee MY, Kim YK, Ryoo KK, Lee YB, Park EJ
Author(s): Kim MJ, Jung KH, Uhm YK, Leem KH, Kim HK
Author(s): Jain SK, McVie R
Author(s): Testa R, Testa I, Manfrini S, Bonfigli AR, Piantanelli L, et al.
Author(s): Santos-Oliveira R, Purdy C, da Silva MP, dos Anjos Carneiro-Leão AM, Machado M, et al.
