Author(s): Serrano Rios M
Obesity and non-insulin-dependent diabetes mellitus (NIDDM) are closely linked. They frequently occur together in patients, and body mass index (BMI) is the strongest risk factor for the development of NIDDM. Both obesity and NIDDM are also major causes of morbidity and mortality from atherogenic macrovascular disease, and they are independent risk factors for coronary heart disease. The risk of developing NIDDM and cardiovascular disease is affected by the regional distribution of body fat. Visceral obesity is associated with a higher degree of risk than peripheral obesity. The metabolic and circulatory changes associated with visceral obesity lead to the development of insulin resistance and increased lipoprotein synthesis. For example, the change in the population profile of lipoproteins in the blood, and alterations in the levels of oxidative stress lead to an increased cardiovascular and macrovascular risk. The changes in lipid metabolism also affect haemorrheological function. They have been linked to decreased fibrinolysis (a serious cardiovascular risk factor) through elevated levels of plasminogen activator inhibitor factor, high blood viscosity, and increased erythrocyte aggregability. Increased BMI also appears to be associated with endothelial dysfunction, which is a major factor in atheroma plaque formation and development of thrombosis. Visceral obesity therefore adds a significant burden to the already increased cardiovascular risk inherent in NIDDM. However, even moderate weight loss may successfully reverse the majority of changes seen with visceral obesity.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/9777322
Author(s): Selby JV, Ray GT, Zhang D, Colby CJ
Author(s): Sidorov J, Shull R, Tomcavage J, Girolami S, Lawton N, et al.
Author(s): Cutajar J
Author(s): Costa J, Borges M, David C, Vaz Carneiro A
Author(s): IDF Clinical Guidelines Task Force
Author(s): Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, et al.
Author(s): Selby JV, Karter AJ, Ackerson LM, Ferrara A, Liu J
Author(s): The Mount Hood 4 Modeling Group
Author(s): Clark CM Jr, Snyder JW, Meek RL, Stutz LM, Parkin CG
Author(s): Marcantonio ER, Goldman L, Mangione CM, Ludwig LE, Muraca B, et al.
Author(s): Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, et al.
Author(s): Carr MC, Brunzell JD
Author(s): van Leiden HA, Dekker JM, Moll AC, Nijpels G, Heine RJ, et al.
Author(s): Stevens RJ, Kothari V, Adler AI, Stratton IM; United Kingdom Prospective Diabetes Study (UKPDS) Group
Author(s): Adler AI, Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, et al.
Author(s): Retnakaran R, Cull CA, Thorne KI, Adler AI, Holman RR
Author(s): Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, et al.
Author(s): Bakris GL, Williams M, Dworkin L, Elliott WJ, Epstein M, et al.
Author(s): Ravid M, Brosh D, Ravid-Safran D, Levy Z, Rachmani R
Author(s): Park JY, Kim HK, Chung YE, Kim SW, Hong SK, et al.
Author(s): Tuomilehto J, Rastenyte D, Birkenhäger WH, Thijs L, Antikainen R, et al.
Author(s): Hansson L, Zanchetti A, Carruthers SG, Dahlöf B, Elmfeldt D, et al.
Author(s): Curb JD, Pressel SL, Cutler JA, Savage PJ, Applegate WB, et al.
Author(s): Anderson JW, Kendall CW, Jenkins DJ
Author(s): Metascreen Writing Committee, Bonadonna R, Cucinotta D, Fedele D, Riccardi G, et al.
Author(s): Costa LA, Canani LH, Lisbôa HR, Tres GS, Gross GL
Author(s): Handelsman Y, Jellinger PS
Author(s): Bonora E, Targher G, Formentini G, Calcaterra F, Lombardi S, et al.