Author(s): Aquilante CL
The sulfonylureas stimulate insulin release from pancreatic beta cells, and have been a cornerstone of Type 2 diabetes pharmacotherapy for over 50 years. Although sulfonylureas are effective antihyperglycemic agents, interindividual variability exists in drug response (i.e., pharmacodynamics), disposition (i.e., pharmacokinetics) and adverse effects. The field of pharmacogenomics has been applied to sulfonylurea clinical studies in order to elucidate the genetic underpinnings of this response variability. Historically, most studies have sought to determine the influence of polymorphisms in drug-metabolizing enzyme genes on sulfonylurea pharmacokinetics in humans. More recently, polymorphisms in sulfonylurea drug target genes and diabetes risk genes have been implicated as important determinants of sulfonylurea pharmacodynamics in patients with Type 2 diabetes. As such, the purpose of this review is to discuss sulfonylurea pharmacogenomics in the setting of Type 2 diabetes, specifically focusing on polymorphisms in drug target and diabetes risk genes, and their relationship with interindividual variability in sulfonylurea response and adverse effects.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/20222815
Author(s): Gerich JE
Author(s): Stumvoll M, Goldstein BJ, van Haeften TW
Author(s): Dey L, Attele AS, Yuan CS
Author(s): Chen L, Magliano DJ, Zimmet PZ
Author(s): International Diabetes Federation
Author(s): Harcourt BE, Penfold SA, Forbes JM
Author(s): Wild S, Roglic G, Green A, Sicree R, King H
Author(s): Shera AS, Jawad F, Maqsood A
Author(s): Tattersall RB, Fajans SS
Author(s): Shields BM, Hicks S, Shepherd MH, Colclough K, Hattersley AT, et al.
Author(s): Kanwal SF, Fazal S, Muhammad Ismail, Nighat Naureen
Author(s): Velho G, Robert JJ
Author(s): Ben Khelifa S, Barboura I, Dandana A, Ferchichi S, Miled A
Author(s): Pittman WB, Acton RT, Barger BO, Bell DS, Go RC, et al.
Author(s): Matejkova-Behanova M
Author(s): Nambam B, Aggarwal S, Jain A
Author(s): Gale EA
Author(s): Fourlanos S, Dotta F, Greenbaum CJ, Palmer JP, Rolandsson O, et al.
Author(s): Cervin C, Lyssenko V, Bakhtadze E, Lindholm E, Nilsson P, et al.
Author(s): Owen KR, McCarthy MI
Author(s): Doria A, Patti ME, Kahn CR
Author(s): Yang L, Zhou X, Luo Y, Sun X, Tang Y, et al.
Author(s): Wheeler E, Barroso I
Author(s): McCarthy MI, Zeggini E
Author(s): Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, et al.
Author(s): Prokopenko I, McCarthy MI, Lindgren CM
Author(s): Sanghera DK, Blackett PR
Author(s): Sladek R, Rocheleau G, Rung J, Dina C, Shen L, et al.
Author(s): Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, et al.
Author(s): Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al.
Author(s): Wellcome Trust Case Control Consortium
Author(s): Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, et al.
Author(s): Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, et al.
Author(s): Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, et al.
Author(s): Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al.
Author(s): Elbein SC, Das SK, Hallman DM, Hanis CL, Hasstedt SJ
Author(s): Ruchat SM, Elks CE, Loos RJ, Vohl MC, Weisnagel SJ, et al.
Author(s): Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, et al.
Author(s): Been LF, Ralhan S, Wander GS, Mehra NK, Singh J, et al.
Author(s): Rees SD, Hydrie MZ, Shera AS, Kumar S, O'Hare JP, et al.
Author(s): Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, et al.
Author(s): Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, et al.
Author(s): Parra EJ, Below JE, Krithika S, Valladares A, Barta JL, et al.
Author(s): Tsai FJ, Yang CF, Chen CC, Chuang LM, Lu CH, et al.
Author(s): Xiang K, Wang Y, Zheng T, Jia W, Li J, et al.
Author(s): Das SK, Hasstedt SJ, Zhang Z, Elbein SC
Author(s): Love-Gregory LD, Wasson J, Ma J, Jin CH, Glaser B, et al.
Author(s): Silander K, Mohlke KL, Scott LJ, Peck EC, Hollstein P, et al.
Author(s): Helgason A, Pálsson S, Thorleifsson G, Grant SF, Emilsson V, et al.
Author(s): van Vliet-Ostaptchouk JV, Shiri-Sverdlov R, Zhernakova A, Strengman E, van Haeften TW, et al.
Author(s): van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, et al.
Author(s): Marquezine GF, Pereira AC, Sousa AG, Mill JG, Hueb WA, et al.
Author(s): Maeda S, Tsukada S, Kanazawa A, Sekine A, Tsunoda T, et al.
Author(s): Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, et al.
Author(s): Cho YM, Kim TH, Lim S, Choi SH, Shin HD, et al.
Author(s): Hu FB, Meigs JB, Li TY, Rifai N, Manson JE
Author(s): Moller DE
Author(s): Reitman ML, Schadt EE
Author(s): Holstein A, Seeringer A, Kovacs P
Author(s): Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, et al.
Author(s): Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, et al.
Author(s): Avery P, Mousa SS, Mousa SA
Author(s): Distefano JK, Watanabe RM
Author(s): Lebovitz HE
Author(s): Schroner Z, Javorsky M, Kozarova M, Tkac I
Author(s): Wolford JK, Vozarova de Courten B
